The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

ZNF202  -  zinc finger protein 202

Homo sapiens

Synonyms: ZKSCAN10, ZSCAN42, Zinc finger protein 202, Zinc finger protein with KRAB and SCAN domains 10
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ZNF202

  • Based on the linkage and apparent transcriptional function of ZNF202, we propose that ZNF202 is a candidate susceptibility gene for human dyslipidemia [1].
  • We tested the hypothesis that a common variant in ZNF202, A154V, predicts risk of ischemic heart disease (IHD), myocardial infarction (MI), and ischemic cerebrovascular disease (ICVD) [2].
  • However, mutation analysis of 39 breast cancer samples revealed no evidence of mutations, indicating that ZNF202 is unlikely to be involved in the pathogenesis of this neoplasm [3].

High impact information on ZNF202

  • PURPOSE OF REVIEW: The zinc finger protein ZNF202 is a transcriptional repressor controlling promoter elements predominantly found in genes involved in lipid metabolism and energy homeostasis [4].
  • Furthermore, we provide an interlink between transcriptional repression by ZNF202 and enhancement of gene activation via nuclear receptor coactivation by SCAN domain protein 1 [4].
  • This transcriptional effect required the presence of the SCAN domain in ZNF202 and the functional integrity of a TATA box at position -24 of ABCA1, whereas the presence of GnT binding motifs was nonessential [5].
  • The zinc finger gene 202 (ZNF202) located within a hypoalphalipoproteinemia susceptibility locus on chromosome 11q23 is a transcriptional repressor of various genes involved in lipid metabolism [5].
  • Biochemical binding studies confirmed the associations of ZNF191 and SDP1 with ZNF202 and established the SCAN domain as a selective hetero- and homotypic oligomerization domain [6].

Biological context of ZNF202


Anatomical context of ZNF202


Associations of ZNF202 with chemical compounds

  • The ZNF202 gene resides in a chromosomal region linked genetically to low high density lipoprotein cholesterol in Utah families [1].

Regulatory relationships of ZNF202


Other interactions of ZNF202


Analytical, diagnostic and therapeutic context of ZNF202


  1. A broad role for the zinc finger protein ZNF202 in human lipid metabolism. Wagner, S., Hess, M.A., Ormonde-Hanson, P., Malandro, J., Hu, H., Chen, M., Kehrer, R., Frodsham, M., Schumacher, C., Beluch, M., Honer, C., Skolnick, M., Ballinger, D., Bowen, B.R. J. Biol. Chem. (2000) [Pubmed]
  2. Zinc Finger Protein 202: a new candidate gene for ischemic heart disease: The Copenhagen City Heart Study. Stene, M.C., Frikke-Schmidt, R., Nordestgaard, B.G., Steffensen, R., Schnohr, P., Tybjaerg-Hansen, A. Atherosclerosis (2006) [Pubmed]
  3. Molecular cloning and characterization of ZNF202: a new gene at 11q23.3 encoding testis-specific zinc finger proteins. Monaco, C., Helmer Citterich, M., Caprini, E., Vorechovsky, I., Russo, G., Croce, C.M., Barbanti-Brodano, G., Negrini, M. Genomics (1998) [Pubmed]
  4. Zinc finger protein ZNF202 structure and function in transcriptional control of HDL metabolism. Schmitz, G., Heimerl, S., Langmann, T. Curr. Opin. Lipidol. (2004) [Pubmed]
  5. The zinc finger protein 202 (ZNF202) is a transcriptional repressor of ATP binding cassette transporter A1 (ABCA1) and ABCG1 gene expression and a modulator of cellular lipid efflux. Porsch-Ozcurumez, M., Langmann, T., Heimerl, S., Borsukova, H., Kaminski, W.E., Drobnik, W., Honer, C., Schumacher, C., Schmitz, G. J. Biol. Chem. (2001) [Pubmed]
  6. The SCAN domain mediates selective oligomerization. Schumacher, C., Wang, H., Honer, C., Ding, W., Koehn, J., Lawrence, Q., Coulis, C.M., Wang, L.L., Ballinger, D., Bowen, B.R., Wagner, S. J. Biol. Chem. (2000) [Pubmed]
  7. ZNF202 is inversely regulated with its target genes ABCA1 and apoE during macrophage differentiation and foam cell formation. Langmann, T., Schumacher, C., Morham, S.G., Honer, C., Heimerl, S., Moehle, C., Schmitz, G. J. Lipid Res. (2003) [Pubmed]
  8. Cross talk of two Krupple transcription factors regulates expression of the ovine FSH receptor gene. Xing, W., Sairam, M.R. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  9. SDP1 is a peroxisome-proliferator-activated receptor gamma 2 co-activator that binds through its SCAN domain. Babb, R., Bowen, B.R. Biochem. J. (2003) [Pubmed]
WikiGenes - Universities