Gene Review:
FSHR - follicle stimulating hormone receptor
Homo sapiens
Synonyms:
FSH-R, FSHRO, Follicle-stimulating hormone receptor, Follitropin receptor, LGR1, ...
- Specificity of cognate ligand-receptor interactions: fusion proteins of human chorionic gonadotropin and the heptahelical receptors for human luteinizing hormone, thyroid-stimulating hormone, and follicle-stimulating hormone. Schubert, R.L., Narayan, P., Puett, D. Endocrinology (2003)
- Expression and actions of both the follicle stimulating hormone receptor and the luteinizing hormone receptor in normal ovarian surface epithelium and ovarian cancer. Parrott, J.A., Doraiswamy, V., Kim, G., Mosher, R., Skinner, M.K. Mol. Cell. Endocrinol. (2001)
- Homozygous mutation within the conserved Ala-Phe-Asn-Glu-Thr motif of exon 7 of the LH receptor causes male pseudohermaphroditism. Gromoll, J., Schulz, A., Borta, H., Gudermann, T., Teerds, K.J., Greschniok, A., Nieschlag, E., Seif, F.J. Eur. J. Endocrinol. (2002)
- Molecular genetic, biochemical, and clinical implications of gonadotropin receptor mutations. Chan, W.Y. Mol. Genet. Metab. (1998)
- Immunization against exon 1 decapeptides from the lutropin/choriogonadotropin receptor or the follitropin receptor as potential male contraceptive. Remy, J.J., Couture, L., Rabesona, H., Haertle, T., Salesse, R. J. Reprod. Immunol. (1996)
- Evaluating the roles of follicle-stimulating hormone receptor polymorphisms in gonadal hyperstimulation associated with severe juvenile primary hypothyroidism. Ryan, G.L., Feng, X., d'Alva, C.B., Zhang, M., Van Voorhis, B.J., Pinto, E.M., Kubias, A.E., Antonini, S.R., Latronico, A.C., Segaloff, D.L. J. Clin. Endocrinol. Metab. (2007)
- FSH directly regulates bone mass. Sun, L., Peng, Y., Sharrow, A.C., Iqbal, J., Zhang, Z., Papachristou, D.J., Zaidi, S., Zhu, L.L., Yaroslavskiy, B.B., Zhou, H., Zallone, A., Sairam, M.R., Kumar, T.R., Bo, W., Braun, J., Cardoso-Landa, L., Schaffler, M.B., Moonga, B.S., Blair, H.C., Zaidi, M. Cell (2006)
- Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Tapanainen, J.S., Aittomäki, K., Min, J., Vaskivuo, T., Huhtaniemi, I.T. Nat. Genet. (1997)
- Mutation in the follicle-stimulating hormone receptor gene causes hereditary hypergonadotropic ovarian failure. Aittomäki, K., Lucena, J.L., Pakarinen, P., Sistonen, P., Tapanainen, J., Gromoll, J., Kaskikari, R., Sankila, E.M., Lehväslaiho, H., Engel, A.R., Nieschlag, E., Huhtaniemi, I., de la Chapelle, A. Cell (1995)
- Co-evolution of ligand-receptor pairs. Moyle, W.R., Campbell, R.K., Myers, R.V., Bernard, M.P., Han, Y., Wang, X. Nature (1994)
- Mutations in the follicle-stimulating hormone-beta (FSH beta) and FSH receptor genes in mice and humans. Layman, L.C. Seminars in reproductive medicine. (2000)
- Expression of gonadotropin and activin receptor messenger ribonucleic acid in human ovarian epithelial neoplasms. Minegishi, T., Kameda, T., Hirakawa, T., Abe, K., Tano, M., Ibuki, Y. Clin. Cancer Res. (2000)
- Hormone-refractory prostate cancer cells express functional follicle-stimulating hormone receptor (FSHR). Ben-Josef, E., Yang, S.Y., Ji, T.H., Bidart, J.M., Garde, S.V., Chopra, D.P., Porter, A.T., Tang, D.G. J. Urol. (1999)
- Induction of infertility in adult male bonnet monkeys by immunization with phage-expressed peptides of the extracellular domain of FSH receptor. Rao, A.J., Ramachandra, S.G., Ramesh, V., Couture, L., Abdennebi, L., Salesse, R., Remy, J.J. Reprod. Biomed. Online (2004)
- An activating mutation of the follicle-stimulating hormone receptor autonomously sustains spermatogenesis in a hypophysectomized man. Gromoll, J., Simoni, M., Nieschlag, E. J. Clin. Endocrinol. Metab. (1996)
- The promoter of murine follicle-stimulating hormone receptor: functional characterization and regulation by transcription factor steroidogenic factor 1. Levallet, J., Koskimies, P., Rahman, N., Huhtaniemi, I. Mol. Endocrinol. (2001)
- Activation of the rat follicle-stimulating hormone receptor promoter by steroidogenic factor 1 is blocked by protein kinase a and requires upstream stimulatory factor binding to a proximal E box element. Heckert, L.L. Mol. Endocrinol. (2001)
- Postendocytotic trafficking of the follicle-stimulating hormone (FSH)-FSH receptor complex. Krishnamurthy, H., Kishi, H., Shi, M., Galet, C., Bhaskaran, R.S., Hirakawa, T., Ascoli, M. Mol. Endocrinol. (2003)
- An activated human follicle-stimulating hormone (FSH) receptor stimulates FSH-like activity in gonadotropin-deficient transgenic mice. Haywood, M., Tymchenko, N., Spaliviero, J., Koch, A., Jimenez, M., Gromoll, J., Simoni, M., Nordhoff, V., Handelsman, D.J., Allan, C.M. Mol. Endocrinol. (2002)
- Human follitropin receptor (FSHR) interacts with the adapter protein 14-3-3tau. Cohen, B.D., Nechamen, C.A., Dias, J.A. Mol. Cell. Endocrinol. (2004)
- Accessibility of rat and human follitropin receptor primary sequence (R265-S296) in situ. Liu, X., DePasquale, J.A., Griswold, M.D., Dias, J.A. Endocrinology (1994)
- Effects of a Thyroid-Stimulating Human Monoclonal Autoantibody (M22) on Functional Activity of LH and FSH Receptors. Tonacchera, M., Ferrarini, E., Dimida, A., Agretti, P., Marco, G.D., Pinchera, A., Sanders, J., Evans, M., Richards, T., Furmaniak, J., Smith, B.R. Thyroid (2006)
- Synthesis of (bis)sulfonic acid, (bis)benzamides as follicle-stimulating hormone (FSH) antagonists. Wrobel, J., Green, D., Jetter, J., Kao, W., Rogers, J., Pérez, M.C., Hardenburg, J., Deecher, D.C., López, F.J., Arey, B.J., Shen, E.S. Bioorg. Med. Chem. (2002)
- Follicle-stimulating hormone ligand and receptor mutations, and gonadal dysfunction. Levallet, J., Pakarinen, P., Huhtaniemi, I.T. Arch. Med. Res. (1999)
- Contribution of specific amino acid residues within the hFSH alpha 26-46 sequence region to FSH receptor-binding activity. Cattini-Schultz, S.V., Stanton, P.G., Robertson, D.M., Hearn, M.T. Pept. Res. (1995)
- Expression of the FSH receptor in the testis. Heckert, L., Griswold, M.D. Recent Prog. Horm. Res. (1993)
- A synthetic peptide corresponding to human FSH beta-subunit 33-53 binds to FSH receptor, stimulates basal estradiol biosynthesis, and is a partial antagonist of FSH. Santa Coloma, T.A., Dattatreyamurty, B., Reichert, L.E. Biochemistry (1990)
- APPL1, APPL2, Akt2 and FOXO1a interact with FSHR in a potential signaling complex. Nechamen, C.A., Thomas, R.M., Dias, J.A. Mol. Cell. Endocrinol. (2007)
- Human follicle-stimulating hormone receptor (FSH-R) promoter/enhancer activity is inhibited by transcriptional factors, from the upstream stimulating factors family, via E-box and newly identified initiator element (Inr) in FSH-R non-expressing cells. Putowski, L.T., Schillings, W.J., Lee, C.M., Reddy, E.P., Jakowicki, J.A. Gynecol. Endocrinol. (2004)
- Role of G protein-coupled receptor kinases on the agonist-induced phosphorylation and internalization of the follitropin receptor. Lazari, M.F., Liu, X., Nakamura, K., Benovic, J.L., Ascoli, M. Mol. Endocrinol. (1999)
- Cellular mechanisms and modulation of activin A- and transforming growth factor beta-mediated differentiation in cultured hen granulosa cells. Johnson, A.L., Bridgham, J.T., Woods, D.C. Biol. Reprod. (2004)
- Association of human follitropin (FSH) receptor with splicing variant of human lutropin/choriogonadotropin receptor negatively controls the expression of human FSH receptor. Yamashita, S., Nakamura, K., Omori, Y., Tsunekawa, K., Murakami, M., Minegishi, T. Mol. Endocrinol. (2005)
- Human controlled ovarian hyperstimulation outcome is a polygenic trait. de Castro, F., Morón, F.J., Montoro, L., Galán, J.J., Hernández, D.P., Padilla, E.S., Ramírez-Lorca, R., Real, L.M., Ruiz, A. Pharmacogenetics (2004)
- Quantification of androgen receptor and follicle-stimulating hormone receptor mRNA levels in human and monkey testes by a ribonuclease-protection assay. Dankbar, B., Sohn, M., Nieschlag, E., Gromoll, J. Int. J. Androl. (1995)
- Localization of the human FSH receptor to chromosome 2 p21 using a genomic probe comprising exon 10. Gromoll, J., Ried, T., Holtgreve-Grez, H., Nieschlag, E., Gudermann, T. J. Mol. Endocrinol. (1994)
- Structural determinants in the second intracellular loop of the human follicle-stimulating hormone receptor are involved in G(s) protein activation. Timossi, C., Maldonado, D., Vizcaíno, A., Lindau-Shepard, B., Conn, P.M., Ulloa-Aguirre, A. Mol. Cell. Endocrinol. (2002)
- Distribution and function of FSH receptor genetic variants in normal men. Asatiani, K., Gromoll, J., Eckardstein, S.V., Zitzmann, M., Nieschlag, E., Simoni, M. Andrologia (2002)