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Chemical Compound Review

NEUROKININ A     3-[[2-[[6-amino-2-[[2-amino- 3-(3H-imidazol...

Synonyms: Neuromedin L, Substance K, Neuromedin L., AGN-PC-00N2TI, AG-H-50475, ...
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Disease relevance of Neurokinin alpha


High impact information on Neurokinin alpha


Biological context of Neurokinin alpha


Anatomical context of Neurokinin alpha


Associations of Neurokinin alpha with other chemical compounds


Gene context of Neurokinin alpha


Analytical, diagnostic and therapeutic context of Neurokinin alpha


  1. Inhibition of cAMP accumulation by intracellular calcium mobilization in C6-2B cells stably transfected with substance K receptor cDNA. DeBernardi, M.A., Seki, T., Brooker, G. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  2. Receptor binding sites for substance P, but not substance K or neuromedin K, are expressed in high concentrations by arterioles, venules, and lymph nodules in surgical specimens obtained from patients with ulcerative colitis and Crohn disease. Mantyh, C.R., Gates, T.S., Zimmerman, R.P., Welton, M.L., Passaro, E.P., Vigna, S.R., Maggio, J.E., Kruger, L., Mantyh, P.W. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  3. Mechanisms of citric acid-induced bronchoconstriction. Ricciardolo, F.L. Am. J. Med. (2001) [Pubmed]
  4. Identification of zymogen and mature forms of human carboxypeptidase H. A processing enzyme for the synthesis of peptide hormones. Hook, V.Y., Affolter, H.U. FEBS Lett. (1988) [Pubmed]
  5. The mas oncogene encodes an angiotensin receptor. Jackson, T.R., Blair, L.A., Marshall, J., Goedert, M., Hanley, M.R. Nature (1988) [Pubmed]
  6. cDNA cloning of bovine substance-K receptor through oocyte expression system. Masu, Y., Nakayama, K., Tamaki, H., Harada, Y., Kuno, M., Nakanishi, S. Nature (1987) [Pubmed]
  7. Stimulation of connective tissue cell growth by substance P and substance K. Nilsson, J., von Euler, A.M., Dalsgaard, C.J. Nature (1985) [Pubmed]
  8. Tissue-specific generation of two preprotachykinin mRNAs from one gene by alternative RNA splicing. Nawa, H., Kotani, H., Nakanishi, S. Nature (1984) [Pubmed]
  9. Cloning, heterologous expression and developmental regulation of a Drosophila receptor for tachykinin-like peptides. Li, X.J., Wolfgang, W., Wu, Y.N., North, R.A., Forte, M. EMBO J. (1991) [Pubmed]
  10. Molecular characterization of a functional cDNA for rat substance P receptor. Yokota, Y., Sasai, Y., Tanaka, K., Fujiwara, T., Tsuchida, K., Shigemoto, R., Kakizuka, A., Ohkubo, H., Nakanishi, S. J. Biol. Chem. (1989) [Pubmed]
  11. The human neurokinin A (substance K) receptor. Molecular cloning of the gene, chromosome localization, and isolation of the cDNA from tracheal and gastric tissues. Gerard, N.P., Eddy, R.L., Shows, T.B., Gerard, C. J. Biol. Chem. (1991) [Pubmed]
  12. The effect of nedocromil sodium on the bronchoconstrictor effect of neurokinin A in subjects with asthma. Joos, G.F., Pauwels, R.A., Van der Straeten, M.E. J. Allergy Clin. Immunol. (1989) [Pubmed]
  13. Novel pharmacology of substance K-binding sites: a third type of tachykinin receptor. Buck, S.H., Burcher, E., Shults, C.W., Lovenberg, W., O'Donohue, T.L. Science (1984) [Pubmed]
  14. Effect of neuropeptides on production of inflammatory cytokines by human monocytes. Lotz, M., Vaughan, J.H., Carson, D.A. Science (1988) [Pubmed]
  15. Autoradiographic localization and characterization of tachykinin receptor binding sites in the rat brain and peripheral tissues. Mantyh, P.W., Gates, T., Mantyh, C.R., Maggio, J.E. J. Neurosci. (1989) [Pubmed]
  16. Dopamine antagonist haloperidol decreases substance P, substance K, and preprotachykinin mRNAs in rat striatonigral neurons. Bannon, M.J., Lee, J.M., Giraud, P., Young, A., Affolter, H.U., Bonner, T.I. J. Biol. Chem. (1986) [Pubmed]
  17. Calcium wave evoked by activation of endogenous or exogenously expressed receptors in Xenopus oocytes. Brooker, G., Seki, T., Croll, D., Wahlestedt, C. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  18. Functional substance P receptors on a rat pancreatic acinar cell line. Womack, M.D., Hanley, M.R., Jessell, T.M. J. Neurosci. (1985) [Pubmed]
  19. Substance P receptors on canine chief cells: localization, characterization, and function. Vigna, S.R., Mantyh, C.R., Soll, A.H., Maggio, J.E., Mantyh, P.W. J. Neurosci. (1989) [Pubmed]
  20. Identification of an epitope in the substance P receptor important for recognition of the common carboxyl-terminal tachykinin sequence. Werge, T.M. J. Biol. Chem. (1994) [Pubmed]
  21. Allosteric activation of the Ca2+ receptor expressed in Xenopus laevis oocytes by NPS 467 or NPS 568. Hammerland, L.G., Garrett, J.E., Hung, B.C., Levinthal, C., Nemeth, E.F. Mol. Pharmacol. (1998) [Pubmed]
  22. Presynaptic transmitters and depolarizing influences regulate development of the substantia nigra in culture. Friedman, W.J., Dreyfus, C.F., McEwen, B., Black, I.B. J. Neurosci. (1988) [Pubmed]
  23. Tachykinin production in granulomas of murine schistosomiasis mansoni. Weinstock, J.V., Blum, A.M. J. Immunol. (1989) [Pubmed]
  24. Tachykinin (substance-P) gene expression in Leydig cells of the human and mouse testis. Chiwakata, C., Brackmann, B., Hunt, N., Davidoff, M., Schulze, W., Ivell, R. Endocrinology (1991) [Pubmed]
  25. Cloning and expression of a rat neuromedin K receptor cDNA. Shigemoto, R., Yokota, Y., Tsuchida, K., Nakanishi, S. J. Biol. Chem. (1990) [Pubmed]
  26. Chromatographic evidence for the presence of multiple tachykinins in the bovine adrenal medulla. Basile, S., Cheung, N.S., Livett, B.G. J. Neurochem. (1992) [Pubmed]
  27. Characterization and autoradiographic localization of multiple tachykinin binding sites in gastrointestinal tract and bladder. Burcher, E., Buck, S.H., Lovenberg, W., O'Donohue, T.L. J. Pharmacol. Exp. Ther. (1986) [Pubmed]
  28. Modification of vasoconstrictor responses in cerebral blood vessels by lesioning of the trigeminal nerve: possible involvement of CGRP. Edvinsson, L., Jansen Olesen, I., Kingman, T.A., McCulloch, J., Uddman, R. Cephalalgia : an international journal of headache. (1995) [Pubmed]
  29. Regional distribution of substance P, neurokinin alpha and neurokinin beta in rat spinal cord, nerve roots and dorsal root ganglia, and the effects of dorsal root section or spinal transection. Ogawa, T., Kanazawa, I., Kimura, S. Brain Res. (1985) [Pubmed]
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