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Ascl1  -  achaete-scute family bHLH transcription...

Rattus norvegicus

Synonyms: Achaete-scute homolog 1, Ash1, Mash-1
 
 
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Disease relevance of Ascl1

  • In contrast, the level of Mash1 mRNA increased on day 1 and then returned to the basal level by 3 days after ischemia [1].
 

High impact information on Ascl1

  • In the vertebrate peripheral nervous system, the proneural genes neurogenin 1 and neurogenin 2 (Ngn1 and Ngn2), and Mash1 are required for sensory and autonomic neurogenesis, respectively [2].
  • These findings suggest that Hes5 and Mash1 may be part of the cell-intrinsic timer in the precursor cells [3].
  • Two days later, at the time of migration of the first granule cells and dentate precursor cells, cells expressing Mash1 are seen in the migratory route from the subventricular zone to the developing dentate gyrus [4].
  • However, at this time, Mash1, Math3, and Id3 expression are all concentrated in the area that specifically gives rise to granule cells and dentate precursor cells [4].
  • Forced expression of MBH1 down-regulates expression of Mash1 and up-regulates neurogenin2/Math4A, a member of neurogenins, in P19 cells during neuronal differentiation [5].
 

Biological context of Ascl1

 

Anatomical context of Ascl1

 

Associations of Ascl1 with chemical compounds

  • Retinoic acid influences the expression of the neuronal regulatory genes Mash-1 and c-ret in the developing rat heart [6].
 

Other interactions of Ascl1

  • The numbers of basal cells expressing the proneural transcriptional activators Mash1, Neurogenin1, and NeuroD all fall precipitously 1 day after lesion [9].
  • Our study identifies a proliferative intermediate precursor, characterized by Mash1 expression, that is the target of EGF-mediated suppression of rod photoreceptor differentiation [10].
 

Analytical, diagnostic and therapeutic context of Ascl1

References

  1. Changes in the expression of Hes5 and Mash1 mRNA in the adult rat dentate gyrus after transient forebrain ischemia. Kawai, T., Takagi, N., Nakahara, M., Takeo, S. Neurosci. Lett. (2005) [Pubmed]
  2. Comparison of the generic neuronal differentiation and neuron subtype specification functions of mammalian achaete-scute and atonal homologs in cultured neural progenitor cells. Lo, L., Dormand, E., Greenwood, A., Anderson, D.J. Development (2002) [Pubmed]
  3. Basic helix-loop-helix proteins and the timing of oligodendrocyte differentiation. Kondo, T., Raff, M. Development (2000) [Pubmed]
  4. Unique expression patterns of cell fate molecules delineate sequential stages of dentate gyrus development. Pleasure, S.J., Collins, A.E., Lowenstein, D.H. J. Neurosci. (2000) [Pubmed]
  5. Mammalian BarH homologue is a potential regulator of neural bHLH genes. Saito, T., Sawamoto, K., Okano, H., Anderson, D.J., Mikoshiba, K. Dev. Biol. (1998) [Pubmed]
  6. Retinoic acid influences the expression of the neuronal regulatory genes Mash-1 and c-ret in the developing rat heart. Shoba, T., Dheen, S.T., Tay, S.S. Neurosci. Lett. (2002) [Pubmed]
  7. Expression of Mash1 in basal cells of rat circumvallate taste buds is dependent upon gustatory innervation. Seta, Y., Toyono, T., Takeda, S., Toyoshima, K. FEBS Lett. (1999) [Pubmed]
  8. Mash-1 is expressed during ROD photoreceptor differentiation and binds an E-box, E(opsin)-1 in the rat opsin gene. Ahmad, I. Brain Res. Dev. Brain Res. (1995) [Pubmed]
  9. Expression patterns of basic helix-loop-helix transcription factors define subsets of olfactory progenitor cells. Manglapus, G.L., Youngentob, S.L., Schwob, J.E. J. Comp. Neurol. (2004) [Pubmed]
  10. Involvement of Mash1 in EGF-mediated regulation of differentiation in the vertebrate retina. Ahmad, I., Dooley, C.M., Afiat, S. Dev. Biol. (1998) [Pubmed]
 
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