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Gene Review

ascl1a  -  achaete-scute family bHLH transcription...

Danio rerio

Synonyms: Achaete-scute homolog 1a, Pituitary-absent protein, SO:0000704, Zash-1a, ash, ...
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High impact information on ascl1a


Biological context of ascl1a


Anatomical context of ascl1a

  • We report here that the four regions previously identified as subpallium, preoptic region, ventral thalamus and hypothalamus (i.e. ventral inferior lobe) in the postembryonic zebrafish brain show Zash-1a expression at 3 days postfertilization (dpf), whereas none of those areas express the bHLH gene neuroD (nrd) between 2 and 5 dpf [4].
  • Zash-1a and -1b gene probes will be extremely useful in the analysis of additional mutations affecting development of the central nervous system in zebrafish embryos [2].
  • The gene is also expressed at sites distinct from cells expressing Zash-1a in the tegmentum, diencephalon, telencephalon, and spinal cord [2].

Other interactions of ascl1a

  • In the mutant cyclops, Zash-1a transcripts are absent from the ventral region of the tegmentum and in the ventral cells of rhombomere 1, while more dorsal expression regions are unaffected [2].


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