Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Slc30a4 - solute carrier family 30 (zinc...

Rattus norvegicus

Synonyms: Dri 27 protein, Solute carrier family 30 member 4, Zinc transporter 4, ZnT-4, Znt4

Ranaldi, G. et al., Huang, L. et al., Liuzzi, J.P. et al., Liuzzi, J.P. et al., Søndergaard, L.G. et al., et al.

Søndergaard, Brock, Stoltenberg, Flyvbjerg, Schmitz, Smidt, Danscher, Rungby,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Slc30a4

The lethal milk mutant has a nonsense mutation at arginine codon 297 in the Znt4 gene [1].
The gene, here designated Znt4, encodes a 430-amino-acid protein that is homologous to two proteins, ZnT2 and ZnT3, responsible for sequestration of zinc into endosomal/lysosomal compartments and synaptic vesicles, respectively [1].
Four putative zinc transporters, known as ZnT-1 through ZnT-4, have now been described [2].
Results of double stainings demonstrated that ZnT4-containing vesicles do not overlap with Zn(II) bodies [3].
The Madin-Darby canine kidney (MDCK) cell line, stably overexpressing rat ZnT4, was used as a tissue culture model of the kidney epithelium [3].

Biological context of Slc30a4

In small intestine and liver, zinc transporter 4 increased from levels found during late gestation, but zinc transporter 1 did not [4].
When zinc was provided as a single oral dose (70 mg/kg body), ZnT-1 and ZnT-2 mRNA levels were increased many fold in small intestine, liver and kidney, whereas ZnT-4 gene expression was not changed [5].

Anatomical context of Slc30a4

In this paper, we show that Dri 27/ZnT4 is localized in the membrane of intracellular vesicles, the majority of which concentrate in the basal cytoplasmic region of polarized enterocytes [6].
In the mammary gland, zinc transporter 4 was most abundant in cells surrounding the alveolar ducts and oriented to the basement lamina [4].
Our study aim was to investigate the effect of acute and chronic exposure to various glucose concentrations on zinc in secretory vesicles, the relation between zinc and insulin, and the presence of two zinc transporters, ZnT1 and ZnT4, in INS-1E cells [7].

Associations of Slc30a4 with chemical compounds

Double staining of rat kidney with Zinquin and anti-ZnT4 antibodies confirmed the in vitro observations, as Zinquin fluorescence appeared to be distinct from ZnT4 immunofluorescence [3].
Rats fed a low Zn or low vitamin A diet had lower ZnT-1 protein and higher ZnT-4 mRNA expression and protein levels compared with controls [8].

Other interactions of Slc30a4

The relative differential in regulation by zinc is ZnT-2 > ZnT-1 > ZnT-4 [5].

References

A novel gene involved in zinc transport is deficient in the lethal milk mouse. Huang, L., Gitschier, J. Nat. Genet. (1997) [Pubmed]
Regulation of the zinc transporter ZnT-1 by dietary zinc. McMahon, R.J., Cousins, R.J. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
Intracellular distribution of labile Zn(II) and zinc transporter expression in kidney and MDCK cells. Ranaldi, G., Perozzi, G., Truong-Tran, A., Zalewski, P., Murgia, C. Am. J. Physiol. Renal Physiol. (2002) [Pubmed]
Zinc transporters 1, 2 and 4 are differentially expressed and localized in rats during pregnancy and lactation. Liuzzi, J.P., Bobo, J.A., Cui, L., McMahon, R.J., Cousins, R.J. J. Nutr. (2003) [Pubmed]
Differential regulation of zinc transporter 1, 2, and 4 mRNA expression by dietary zinc in rats. Liuzzi, J.P., Blanchard, R.K., Cousins, R.J. J. Nutr. (2001) [Pubmed]
Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells. Murgia, C., Vespignani, I., Cerase, J., Nobili, F., Perozzi, G. Am. J. Physiol. (1999) [Pubmed]
Zinc fluxes during acute and chronic exposure of INS-1E cells to increasing glucose levels. Søndergaard, L.G., Brock, B., Stoltenberg, M., Flyvbjerg, A., Schmitz, O., Smidt, K., Danscher, G., Rungby, J. Horm. Metab. Res. (2005) [Pubmed]
Zinc transporters in the rat mammary gland respond to marginal zinc and vitamin A intakes during lactation. Kelleher, S.L., Lönnerdal, B. J. Nutr. (2002) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

MTPB1	Arabidopsis thaliana
SLC30A4	Bos taurus
SLC30A4	Canis lupus familiaris
slc30a4	Danio rerio
SLC30A4	Gallus gallus
SLC30A4	Homo sapiens
Slc30a4	Mus musculus
SLC30A4	Pan troglodytes
slc30a4	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.