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Gene Review

Slc30a3  -  solute carrier family 30 (zinc...

Mus musculus

Synonyms: Solute carrier family 30 member 3, Zinc transporter 3, ZnT-3, Znt3
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Disease relevance of Slc30a3

  • ZnT-3 reactivity was also present in the outer plexiform, inner nuclear, inner plexiform, and ganglion cell layers [1].

Psychiatry related information on Slc30a3


High impact information on Slc30a3


Biological context of Slc30a3

  • During embryogenesis and early postnatal stages, ZnT3 transcripts were detected in several areas [8].
  • After 10 and 30 days, however, downregulation of ZnT3 was paralleled by a distinct reduction in ZnSeAMG staining [9].

Anatomical context of Slc30a3


Associations of Slc30a3 with chemical compounds

  • Furthermore, compared with zinc transporter 3 (Znt3)-null mice, Znt3/Mt3 double-null mice exhibited further reductions in neuronal death in CA1 following kainate-induced seizures [13].
  • The hippocampi of ZnT3-/- mice showed typical seizure-related neuronal damage in response to kainic acid, demonstrating that damage to the targets of zinc-containing neurons can occur independently of synaptically released zinc [10].
  • Furthermore, neither amplitude nor duration of pharmacologically isolated N-methyl-D-aspartate, non-N-methyl-D-aspartate, GABA(A), and GABA(B) receptor-mediated postsynaptic potentials differed between zinc transporter 3 knockout and wild-type mice [12].
  • However, mRNA levels of the delta subunit of adaptor protein complex (AP)-3, which modulates the level of Znt3 levels, were altered by estrogen depletion or replacement [14].
  • Studies of the central nervous system have localized the zinc-transporter-3 (ZnT-3) protein to synaptic vesicles containing glutamate and zinc [1].

Other interactions of Slc30a3

  • To determine the net effects of vesicular zinc release in the brain in vivo, we examined seizure susceptibility and seizure-related neuronal damage in mice with targeted disruption of the gene encoding the zinc transporter, ZnT3 (ZnT3-/- mice) [10].
  • VAChT-positive preganglionic neurons were found to terminate on ZnT3 neuronal somata [15].
  • It is therefore concluded that ZnT3 and zinc ions are present in a subpopulation of TH-positive, NPY-negative neurons in the rodent SCG, supporting the notion that vesicular zinc ions may play a special role in the peripheral sympathetic adrenergic system [15].
  • While mh mice show a severe reduction of vesicular zinc (TIMM staining) owing to mislocalization and degradation of the Zinc transporter ZnT-3, the TIMM and ZnT-3 staining patterns in mh(2J) varies, with normal expression in hippocampal mossy fibers, but abnormal patterns in neocortex [16].
  • These results suggest that in the barrel cortex ZnT3, synapsin I or synaptophysin are not determinant for the activity-dependent regulation of the synaptic zinc level [2].

Analytical, diagnostic and therapeutic context of Slc30a3


  1. Localization of zinc transporter-3 (ZnT-3) in mouse retina. Redenti, S., Chappell, R.L. Vision Res. (2004) [Pubmed]
  2. Dissociation of synaptic zinc level and zinc transporter 3 expression during postnatal development and after sensory deprivation in the barrel cortex of mice. Liguz-Lecznar, M., Nowicka, D., Czupryn, A., Skangiel-Kramska, J. Brain Res. Bull. (2005) [Pubmed]
  3. Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles. Kantheti, P., Qiao, X., Diaz, M.E., Peden, A.A., Meyer, G.E., Carskadon, S.L., Kapfhamer, D., Sufalko, D., Robinson, M.S., Noebels, J.L., Burmeister, M. Neuron (1998) [Pubmed]
  4. Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice. Lee, J.Y., Cole, T.B., Palmiter, R.D., Suh, S.W., Koh, J.Y. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene. Cole, T.B., Wenzel, H.J., Kafer, K.E., Schwartzkroin, P.A., Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  6. Ultrastructural localization of zinc transporter-3 (ZnT-3) to synaptic vesicle membranes within mossy fiber boutons in the hippocampus of mouse and monkey. Wenzel, H.J., Cole, T.B., Born, D.E., Schwartzkroin, P.A., Palmiter, R.D. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  7. Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles. Salazar, G., Craige, B., Wainer, B.H., Guo, J., De Camilli, P., Faundez, V. Mol. Biol. Cell (2005) [Pubmed]
  8. Developmental expression of ZnT3 in mouse brain: correlation between the vesicular zinc transporter protein and chelatable vesicular zinc (CVZ) cells. Glial and neuronal CVZ cells interact. Valente, T., Auladell, C. Mol. Cell. Neurosci. (2002) [Pubmed]
  9. Adrenalectomy-induced ZnT3 downregulation in mouse hippocampus is followed by vesicular zinc depletion. Suh, S.W., Jo, S.M., Vajda, Z., Danscher, G. Neurosci. Lett. (2005) [Pubmed]
  10. Seizures and neuronal damage in mice lacking vesicular zinc. Cole, T.B., Robbins, C.A., Wenzel, H.J., Schwartzkroin, P.A., Palmiter, R.D. Epilepsy Res. (2000) [Pubmed]
  11. Dynamic zinc pools in mouse choroid plexus. Wang, Z.Y., Stoltenberg, M., Jo, S.M., Huang, L., Larsen, A., Dahlström, A., Danscher, G. Neuroreport (2004) [Pubmed]
  12. Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice. Lopantsev, V., Wenzel, H.J., Cole, T.B., Palmiter, R.D., Schwartzkroin, P.A. Neuroscience (2003) [Pubmed]
  13. Zinc released from metallothionein-iii may contribute to hippocampal CA1 and thalamic neuronal death following acute brain injury. Lee, J.Y., Kim, J.H., Palmiter, R.D., Koh, J.Y. Exp. Neurol. (2003) [Pubmed]
  14. Estrogen decreases zinc transporter 3 expression and synaptic vesicle zinc levels in mouse brain. Lee, J.Y., Kim, J.H., Hong, S.H., Lee, J.Y., Cherny, R.A., Bush, A.I., Palmiter, R.D., Koh, J.Y. J. Biol. Chem. (2004) [Pubmed]
  15. Zinc transporter 3 and zinc ions in the rodent superior cervical ganglion neurons. Wang, Z.Y., Danscher, G., Dahlström, A., Li, J.Y. Neuroscience (2003) [Pubmed]
  16. Genetic and phenotypic analysis of the mouse mutant mh2J, an Ap3d allele caused by IAP element insertion. Kantheti, P., Diaz, M.E., Peden, A.E., Seong, E.E., Dolan, D.F., Robinson, M.S., Noebels, J.L., Burmeister, M.L. Mamm. Genome (2003) [Pubmed]
  17. Accumulation of zinc in degenerating hippocampal neurons of ZnT3-null mice after seizures: evidence against synaptic vesicle origin. Lee, J.Y., Cole, T.B., Palmiter, R.D., Koh, J.Y. J. Neurosci. (2000) [Pubmed]
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