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Gene Review

WNT5A  -  wingless-type MMTV integration site family...

Homo sapiens

Synonyms: Protein Wnt-5a, hWNT5A
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Disease relevance of WNT5A


High impact information on WNT5A

  • The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation [1].
  • Microarray--assisted gene--expression screens of human macrophages revealed WNT5A, a homolog of Wingless, a key regulator of Drosophila melanogaster embryonic segmentation and patterning, to be consistently up-regulated following stimulation with different mycobacterial species and conserved bacterial structures [1].
  • Functional studies showed that WNT5A and FZD5 regulate the microbially induced interleukin-12 response of antigen-presenting cells and interferon-gamma production by mycobacterial antigen-stimulated T cells [1].
  • The results are applied to a family of Boolean networks derived from gene-expression data collected in a study of metastatic melanoma, the intent being to devise a control strategy that reduces the WNT5A gene's action in affecting biological regulation [4].
  • Previous studies have shown that three members of the Wnt signaling pathway, the ligand WNT5A, the receptor FZ4, and the Wnt antagonist FRZB1, are implicated in the formation and differentiation of the digits [5].

Biological context of WNT5A


Anatomical context of WNT5A


Associations of WNT5A with chemical compounds

  • Furthermore, we detected an increase of WNT5A protein in the medium by DHT and inhibition of the increase by BMP-2 [11].

Regulatory relationships of WNT5A


Other interactions of WNT5A

  • Here, WNT5A was characterized as the evolutionarily conserved target of the STAT3 signaling cascade based on 11-bp-spaced tandem STAT3-binding sites within intron 4 of human, chimpanzee, cow, mouse and rat WNT5A orthologs [9].
  • It is noteworthy that all six Wnt ligands that are overexpressed in malignant cell lines are known to signal through the canonical Wnt/beta-catenin signaling pathway, whereas down-regulated WNT5A and WNT5B ligands signal via the non-canonical pathway [12].
  • CONCLUSIONS: Early induction of WNT5A, coupled with the coordinated induction and repression of genes that modulate the Wnt signaling pathway, led to the early, selective induction of WISP1 and no other Wnt-inducible genes [13].
  • SNP of genes encoding components of the cytokine-induced WNT5A signaling loop is a predicted risk factor for RA and cancer, especially diffuse-type gastric and pancreatic cancer [9].
  • The recent development of high-throughput technologies aimed at global molecular profiling of cancer is switching on the spotlight at previously unknown candidate genes involved in melanoma, such as WNT5A and BRAF [14].

Analytical, diagnostic and therapeutic context of WNT5A


  1. The Wingless homolog WNT5A and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blumenthal, A., Ehlers, S., Lauber, J., Buer, J., Lange, C., Goldmann, T., Heine, H., Brandt, E., Reiling, N. Blood (2006) [Pubmed]
  2. Expression and regulation of WNT5A and WNT5B in human cancer: up-regulation of WNT5A by TNFalpha in MKN45 cells and up-regulation of WNT5B by beta-estradiol in MCF-7 cells. Saitoh, T., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  3. WNT5A expression increases during melanoma progression and correlates with outcome. Da Forno, P.D., Pringle, J.H., Hutchinson, P., Osborn, J., Huang, Q., Potter, L., Hancox, R.A., Fletcher, A., Saldanha, G.S. Clin. Cancer Res. (2008) [Pubmed]
  4. Intervention in a family of Boolean networks. Choudhary, A., Datta, A., Bittner, M.L., Dougherty, E.R. Bioinformatics (2006) [Pubmed]
  5. Comparative analysis of the expression and regulation of Wnt5a, Fz4, and Frzb1 during digit formation and in micromass cultures. Chimal-Monroy, J., Montero, J.A., Gañan, Y., Macias, D., Garcia-Porrero, J.A., Hurle, J.M. Dev. Dyn. (2002) [Pubmed]
  6. Conserved POU-binding site linked to SP1-binding site within FZD5 promoter: Transcriptional mechanisms of FZD5 in undifferentiated human ES cells, fetal liver/spleen, adult colon, pancreatic islet, and diffuse-type gastric cancer. Katoh, Y., Katoh, M. Int. J. Oncol. (2007) [Pubmed]
  7. Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21. Clark, C.C., Cohen, I., Eichstetter, I., Cannizzaro, L.A., McPherson, J.D., Wasmuth, J.J., Iozzo, R.V. Genomics (1993) [Pubmed]
  8. Comparative genomics on Wnt5a and Wnt5b genes. Katoh, M., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  9. STAT3-induced WNT5A signaling loop in embryonic stem cells, adult normal tissues, chronic persistent inflammation, rheumatoid arthritis and cancer (Review). Katoh, M., Katoh, M. Int. J. Mol. Med. (2007) [Pubmed]
  10. Frequent up-regulation of WNT5A mRNA in primary gastric cancer. Saitoh, T., Mine, T., Katoh, M. Int. J. Mol. Med. (2002) [Pubmed]
  11. Alteration of gene expression in response to bone morphogenetic protein-2 in androgen-dependent human prostate cancer LNCaP cells. Kumagai, T., Tomari, K., Shimizu, T., Takeda, K. Int. J. Mol. Med. (2006) [Pubmed]
  12. Redundant expression of canonical Wnt ligands in human breast cancer cell lines. Benhaj, K., Akcali, K.C., Ozturk, M. Oncol. Rep. (2006) [Pubmed]
  13. Gene expression after crush injury of human saphenous vein: using microarrays to define the transcriptional profile. Price, R.M., Tulsyan, N., Dermody, J.J., Schwalb, M., Soteropoulos, P., Castronuovo, J.J. J. Am. Coll. Surg. (2004) [Pubmed]
  14. Genetic progression of metastatic melanoma. Rodolfo, M., Daniotti, M., Vallacchi, V. Cancer Lett. (2004) [Pubmed]
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