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Gene Review

TNS3  -  tensin 3

Homo sapiens

Synonyms: FLJ13732, H_NH0549I23.2, TEM6, TENS1, TPP, ...
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Disease relevance of TNS3

  • The proposed Rule of Tens for current severe psoriasis from the clinician's viewpoint is: 'Current Severe Psoriasis = Body Surface Area involved > 10% or Psoriasis Area and Severity Index score > 10 or Dermatology Life Quality Index score > 10' [1].
  • From the results (70% of the TNS-1 wrists had 50 to 100% pain relief; 10% of the TNS-2 and 15% of the TNS-3 wrists had some improvement), TNS appears to reduce joint pain and to offer a supplement to antiinflammatory drugs [2].
  • The importance of the BIA and Cardio Tens monitoring in determining the optimal dry body weight and improving the cardiovascular condition of the patients is emphasized [3].

High impact information on TNS3

  • TEM-109 exhibited hydrolytic activity against ceftazidime similar to that of TEM-6 (k(cat), 56 s(-1) and 105 s(-1), respectively; K(m) values, 226 and 247 microM, respectively) [4].
  • The 50% inhibitory concentrations of clavulanate and tazobactam (0.13 microM and 0.27 microM, respectively) were 5- to 10-fold higher for TEM-109 than for TEM-6 (0.01 and 0.06 microM, respectively) but were almost 10-fold lower than those for TEM-33 [4].
  • For the purpose of pain induction, 32 healthy naive female subjects attended on 2 occasions, the first during which baseline data were obtained and the second during which the women were randomly allocated to 1 of 4 groups: Control, Placebo, TENS-1 (110 Hz) or TENS-2 (4 Hz) [5].
  • When the bacteria were screened for ESBL production and the lower inoculum was used, several strains with ESBLs, including CTX-M-10, TEM-3, TEM-10, TEM-12, TEM-6, SHV-18, and K1, gave false-negative results for one or more antimicrobial agents (MICs below the NCCLS screening concentration for detecting suspected ESBLs) [6].
  • The expressions of TEM-2 and TEM-6 were found to be not significantly different between tumor tissues and normal tissues (P > 0.05) [7].

Anatomical context of TNS3

  • Each conditioning stimulus (TENS1, TENS2, PECs1, Sham PEC) was applied for a 2-minute period either segmentally on the sural nerve itself or heterotopically on the skin overlying the first interosseous space of the contralateral hand [8].

Associations of TNS3 with chemical compounds


Other interactions of TNS3

  • SUBJECTS AND SETTING: Fifteen people with MS were recruited and randomly allocated to one of the following groups under double blind conditions (n = 5 per group): TENS 1 (4 Hz, 200 micros), TENS 2 (110 Hz, 200 micros), placebo TENS [10].

Analytical, diagnostic and therapeutic context of TNS3

  • The importance of bioimpedance (BIA) analysis and Cardio Tens (24-h ABPM and ECG) monitoring in the dialysis programme [3].


  1. Current severe psoriasis and the rule of tens. Finlay, A.Y. Br. J. Dermatol. (2005) [Pubmed]
  2. Transcutaneous nerve stimulation in rheumatoid arthritis. Kumar, V.N., Redford, J.B. Archives of physical medicine and rehabilitation. (1982) [Pubmed]
  3. The importance of bioimpedance (BIA) analysis and Cardio Tens (24-h ABPM and ECG) monitoring in the dialysis programme. Löcsey, L., Szlanka, B., Ménes, I., Kövér, A., Vitai, E., Malkócs, Z., Keresztes, P., Paragh, G. International urology and nephrology. (1999) [Pubmed]
  4. TEM-109 (CMT-5), a natural complex mutant of TEM-1 beta-lactamase combining the amino acid substitutions of TEM-6 and TEM-33 (IRT-5). Robin, F., Delmas, J., Chanal, C., Sirot, D., Sirot, J., Bonnet, R. Antimicrob. Agents Chemother. (2005) [Pubmed]
  5. A double-blind investigation of the hypoalgesic effects of transcutaneous electrical nerve stimulation upon experimentally induced ischaemic pain. Walsh, D.M., Liggett, C., Baxter, D., Allen, J.M. Pain (1995) [Pubmed]
  6. Effects of inoculum and beta-lactamase activity in AmpC- and extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae clinical isolates tested by using NCCLS ESBL methodology. Queenan, A.M., Foleno, B., Gownley, C., Wira, E., Bush, K. J. Clin. Microbiol. (2004) [Pubmed]
  7. Prognostic values of tumor endothelial markers in patients with colorectal cancer. Rmali, K.A., Puntis, M.C., Jiang, W.G. World J. Gastroenterol. (2005) [Pubmed]
  8. Depressive effects of segmental and heterotopic application of transcutaneous electrical nerve stimulation and piezo-electric current on lower limb nociceptive flexion reflex in human subjects. Danziger, N., Rozenberg, S., Bourgeois, P., Charpentier, G., Willer, J.C. Archives of physical medicine and rehabilitation. (1998) [Pubmed]
  9. The surgical pathology and cytopathology of US Persian Gulf War military veterans. Specht, C.S., Lewin-Smith, M.R., Kalasinsky, V.F., Peterson, M.R., Mullick, F.G. Arch. Pathol. Lab. Med. (2000) [Pubmed]
  10. A pilot investigation of the hypoalgesic effects of transcutaneous electrical nerve stimulation upon low back pain in people with multiple sclerosis. Al-Smadi, J., Warke, K., Wilson, I., Cramp, A.F., Noble, G., Walsh, D.M., Lowe-Strong, A.S. Clinical rehabilitation. (2003) [Pubmed]
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