The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

H60a  -  histocompatibility 60a

Mus musculus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of H60


High impact information on H60

  • Here we demonstrate that ectopic expression of the murine NKG2D ligands Rae1beta or H60 in several tumour cell lines results in potent rejection of the tumour cells by syngeneic mice [6].
  • After exposure to carcinogens, skin cells expressed Rae-1 and H60, major histocompatibility complex-related molecules structurally resembling human MICA [7].
  • Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide [8].
  • Ectopic expression of RAE-1 and H60 confers target susceptibility to NK cell attack [9].
  • We show that the mouse cytomegalovirus (MCMV) molecule fcr-1 promotes a rapid down-regulation of NKG2D ligands murine UL16-binding protein like transcript (MULT)-1 and H60 from the cell surface [10].

Biological context of H60


Anatomical context of H60

  • NKG2D-independent suppression of T cell proliferation by H60 and MICA [14].
  • Infection of BALB/c 3T3 cells with the Smith strain of MCMV resulted in strong down-regulation of H60, a high affinity ligand for NKG2D, from the surface of virus-infected cells [15].
  • The development of BM failure was associated with a significant increase in activated CD4(+)CD25(+) T cells that did not express intracellular FoxP3, whereas inclusion of normal CD4(+)CD25(+) regulatory T cells in combination with C57BL/6 LN cells aborted H60-specific T cell expansion and prevented BM destruction [5].
  • In the present study, infusion of lymph node (LN) cells from C57BL/6 mice into C.B10-H2(b)/LilMcd (C.B10) recipients that are mismatched at multiple minor histocompatibility Ags, including the immunodominant Ag H60, produced fatal aplastic anemia [5].

Associations of H60 with chemical compounds


Physical interactions of H60


Regulatory relationships of H60


Other interactions of H60

  • Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity [6].
  • Responsiveness to H60- and MICA-mediated suppression requires IL-10 and involves a receptor other than NKG2D [14].
  • Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease [17].
  • While RAE-1B6 and H60 display relatively high affinities for NKG2D with K(D) in the 20-30 nM range and k(off )in the 0.03s(-1) to 0.06s(-1) range (t(1/2) approximately 10-20s); the RAE-1 delta variant binds with a lower affinity: K(D) of approximately 750 nM [18].
  • In contrast, even a higher expression of H60 molecule on the target cells failed to overcome the inhibition mediated by Ly49A/G receptors [12].

Analytical, diagnostic and therapeutic context of H60

  • Western blotting and immunohistochemical assays showed that there was absent or faint H60 and RAE-1 expression in sham liver, but they were apparently increased in ischemic liver; however, the expressions were significantly decreased in the presence of YS [2].
  • Southern blot analysis revealed that the H60 locus was polymorphic among the BALB and the B6 strains [11].
  • Understanding why the H60 peptide is so immunogenic has important implications in tissue transplantation and vaccine design [8].
  • These findings show that immunodominance applies to antigenically complex transplantation settings in vivo and that the responses to the H60 minor H Ag dominates in this model [13].
  • The resultant fusion protein, named H60/TNT-3, was produced in NS0 cells and determined by ELISA to possess an H60 epitope [4].


  1. Selective down-regulation of the NKG2D ligand H60 by mouse cytomegalovirus m155 glycoprotein. Hasan, M., Krmpotic, A., Ruzsics, Z., Bubic, I., Lenac, T., Halenius, A., Loewendorf, A., Messerle, M., Hengel, H., Jonjic, S., Koszinowski, U.H. J. Virol. (2005) [Pubmed]
  2. Yisheng Injection Decreases the Expression of H60 and RAE-1 Genes in Ischemic Mice Liver. Cheng, F., Feng, L., Li, S., Tan, J., Cao, L., He, Y., Ye, Z., Li, Y. Transplant. Proc. (2006) [Pubmed]
  3. IFN-dependent down-regulation of the NKG2D ligand H60 on tumors. Bui, J.D., Carayannopoulos, L.N., Lanier, L.L., Yokoyama, W.M., Schreiber, R.D. J. Immunol. (2006) [Pubmed]
  4. H60/TNT-3 fusion protein activates NK cells in vitro and improves immunotherapeutic outcome in murine syngeneic tumor models. Flanagan, M.L., Khawli, L.A., Hu, P., Epstein, A.L. J. Immunother. (2006) [Pubmed]
  5. Minor antigen h60-mediated aplastic anemia is ameliorated by immunosuppression and the infusion of regulatory T cells. Chen, J., Ellison, F.M., Eckhaus, M.A., Smith, A.L., Keyvanfar, K., Calado, R.T., Young, N.S. J. Immunol. (2007) [Pubmed]
  6. Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity. Diefenbach, A., Jensen, E.R., Jamieson, A.M., Raulet, D.H. Nature (2001) [Pubmed]
  7. Regulation of cutaneous malignancy by gammadelta T cells. Girardi, M., Oppenheim, D.E., Steele, C.R., Lewis, J.M., Glusac, E., Filler, R., Hobby, P., Sutton, B., Tigelaar, R.E., Hayday, A.C. Science (2001) [Pubmed]
  8. Immunodominance of H60 is caused by an abnormally high precursor T cell pool directed against its unique minor histocompatibility antigen peptide. Choi, E.Y., Christianson, G.J., Yoshimura, Y., Sproule, T.J., Jung, N., Joyce, S., Roopenian, D.C. Immunity (2002) [Pubmed]
  9. Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. Cerwenka, A., Bakker, A.B., McClanahan, T., Wagner, J., Wu, J., Phillips, J.H., Lanier, L.L. Immunity (2000) [Pubmed]
  10. The herpesviral Fc receptor fcr-1 down-regulates the NKG2D ligands MULT-1 and H60. Lenac, T., Budt, M., Arapovic, J., Hasan, M., Zimmermann, A., Simic, H., Krmpotic, A., Messerle, M., Ruzsics, Z., Koszinowski, U.H., Hengel, H., Jonjic, S. J. Exp. Med. (2006) [Pubmed]
  11. The molecular and functional characterization of a dominant minor H antigen, H60. Malarkannan, S., Shih, P.P., Eden, P.A., Horng, T., Zuberi, A.R., Christianson, G., Roopenian, D., Shastri, N. J. Immunol. (1998) [Pubmed]
  12. NKG2D receptor-mediated NK cell function is regulated by inhibitory Ly49 receptors. Regunathan, J., Chen, Y., Wang, D., Malarkannan, S. Blood (2005) [Pubmed]
  13. Quantitative analysis of the immune response to mouse non-MHC transplantation antigens in vivo: the H60 histocompatibility antigen dominates over all others. Choi, E.Y., Yoshimura, Y., Christianson, G.J., Sproule, T.J., Malarkannan, S., Shastri, N., Joyce, S., Roopenian, D.C. J. Immunol. (2001) [Pubmed]
  14. NKG2D-independent suppression of T cell proliferation by H60 and MICA. Kriegeskorte, A.K., Gebhardt, F.E., Porcellini, S., Schiemann, M., Stemberger, C., Franz, T.J., Huster, K.M., Carayannopoulos, L.N., Yokoyama, W.M., Colonna, M., Siccardi, A.G., Bauer, S., Busch, D.H. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. The cytomegalovirus m155 gene product subverts natural killer cell antiviral protection by disruption of H60-NKG2D interactions. Lodoen, M.B., Abenes, G., Umamoto, S., Houchins, J.P., Liu, F., Lanier, L.L. J. Exp. Med. (2004) [Pubmed]
  16. Cutting edge: the minor histocompatibility antigen H60 peptide interacts with both H-2Kb and NKG2D. Cerwenka, A., O'Callaghan, C.A., Hamerman, J.A., Yadav, R., Ajayi, W., Roopenian, D.C., Joyce, S., Lanier, L.L. J. Immunol. (2002) [Pubmed]
  17. Real-time T-cell profiling identifies H60 as a major minor histocompatibility antigen in murine graft-versus-host disease. Choi, E.Y., Christianson, G.J., Yoshimura, Y., Jung, N., Sproule, T.J., Malarkannan, S., Joyce, S., Roopenian, D.C. Blood (2002) [Pubmed]
  18. Ligands for murine NKG2D display heterogeneous binding behavior. Carayannopoulos, L.N., Naidenko, O.V., Kinder, J., Ho, E.L., Fremont, D.H., Yokoyama, W.M. Eur. J. Immunol. (2002) [Pubmed]
WikiGenes - Universities