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Gene Review

CD2  -  CD2 molecule

Macaca mulatta

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High impact information on CD2

  • At 90 min, the dying monkeys showed in the circulation a dramatic increase of polymorphonuclear leukocytes and decreases of NK cells and monocytes (CD16 and CD56 markers) as well as of lymphocytes with HLA-DR, CD2, CD8, and IL2R alpha (CD25) markers [1].
  • In nonstressed adult monkeys, we found differences in the level of expression of CD2 on T cells, revealing two distinct subsets of T cells, CD2dim and CD2bright cells, with CD2bright cells predominately coexpressing CD8 [2].
  • Selective reduction in CD2 expression on CD2bright/CD8+ lymphocytes from cynomolgus monkeys (Macaca fascicularis) in response to acute stress [2].
  • Using a "knock-in" mutagenesis approach starting with Baboon CD2, which does not bind MEDI-507, 6F10.3 and 4B2, we have identified three residues in the adhesion domain of human CD2 which are critical for its binding to these mAbs [3].
  • No changes in CD2, CD4, CD8, CD20, CD29, and CD45R cell numbers in lymph node of infected animals were seen when compared to control animals [4].

Anatomical context of CD2

  • The [Ca2+]i responses to both CD3 mAb and CD2 mAb were 10-50% less in T cells from Walter Reed stage 2 animals than in healthy controls [5].
  • Reactivity with the following antigens was assessed: MHC class I, II-DR, -DQ, and -DP antigens; leukocyte markers CD1, CD2, CD3, CD4, CD8, CD14, CD16, CD25, CD57; a proliferation associated nuclear antigen; interferon-gamma and tumor necrosis factor-alpha [6].

Analytical, diagnostic and therapeutic context of CD2


  1. Immunity and responses of circulating leukocytes and lymphocytes in monkeys to aerosolized staphylococcal enterotoxin B. Tseng, J., Komisar, J.L., Chen, J.Y., Hunt, R.E., Johnson, A.J., Pitt, L., Rivera, J., Ruble, D.L., Trout, R., Vega, A. Infect. Immun. (1993) [Pubmed]
  2. Selective reduction in CD2 expression on CD2bright/CD8+ lymphocytes from cynomolgus monkeys (Macaca fascicularis) in response to acute stress. Rogers, C.J., Brissette-Storkus, C.S., Hayes, L.A., Cameron, J.L., Chambers, W.H. J. Neuroimmunol. (1998) [Pubmed]
  3. Analysis of human and primate CD2 molecules by protein sequence and epitope mapping with anti-human CD2 antibodies. Damschroder, M.M., Kozhich, A.A., Woods, R.M., Cheng, L., Mullikin, B.A., Wilson, S.D., Ulbrandt, N.D., Bachy, C.M., Wu, H., Suzich, J.A., Kiener, P.A., Dall'Acqua, W.F., White, W.I. Mol. Immunol. (2004) [Pubmed]
  4. Histopathological, lymphoscintigraphical, and immunological changes in the inguinal lymph nodes of rhesus monkeys during the early course of infection with Brugia malayi. Dennis, V.A., Lasater, B.L., Blanchard, J.L., Lowrie, R.C., Campeau, R.J. Exp. Parasitol. (1998) [Pubmed]
  5. CD4 and CD8 T cells from SIV-infected macaques have defective signaling responses after perturbation of either CD3 or CD2 receptors. Gale, M.J., Ledbetter, J.A., Schieven, G.L., Jonker, M., Morton, W.R., Benveniste, R.E., Clark, E.A. Int. Immunol. (1990) [Pubmed]
  6. Monoclonal antibodies for immunohistochemical labeling of immunocompetent cells in frozen sections of rhesus monkey tissues. Stevens, H.P., van der Kwast, T.H., Timmermans, A., Stouten, N., Jonker, M. J. Med. Primatol. (1991) [Pubmed]
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