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Gene Review

Cd2  -  CD2 antigen

Mus musculus

Synonyms: LFA-2, LFA-3 receptor, Ly-37, Ly37, Lymphocyte antigen 37, ...
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Disease relevance of Cd2

  • B6.yaa mice are not overtly autoimmune, but the addition of Sle1, which contains the autoimmune-predisposing Slam/Cd2 haplotype, causes the development of fatal lupus with numerous immunological aberrations [1].
  • We have transduced a recombinant retrovirus encoding the mouse CD2 antigen into STRO-1+ cells selected from adult and fetal BM [2].

High impact information on Cd2


Biological context of Cd2


Anatomical context of Cd2


Associations of Cd2 with chemical compounds

  • Biosynthetic labeling of DBA/2 thymocytes with [35S]methionine showed that the size of the CD2 precursor molecule was 43 kDa which was processed to approximately 55-65 kDa in the mature molecule. mAb 12-15 was also reactive with the tunicamycin-treated form of the CD2 antigen suggesting that the cross-reactive epitope was of protein nature [10].
  • Adhesion is mediated by a family of glycoprotein molecules, of which the LFA-1 and LFA-2 molecules appear as the most likely candidates [7].

Other interactions of Cd2

  • We show that most resting LAK2+ cells lack surface expression of CD3, whereas nearly 60% express CD2 antigen [11].

Analytical, diagnostic and therapeutic context of Cd2

  • Our data, in addition to demonstrating for the first time the efficacy of RM2-2 anti-CD2 mAb, suggest that CD2 antigen is a suitable target for the induction of transplantation tolerance [5].
  • By two-color immunofluorescence using B or T cell-specific reagents and cell sorting in combination with biochemical analysis we provide evidence that the CD2 antigen is present on mouse B and T cells [9].


  1. A Tlr7 translocation accelerates systemic autoimmunity in murine lupus. Subramanian, S., Tus, K., Li, Q.Z., Wang, A., Tian, X.H., Zhou, J., Liang, C., Bartov, G., McDaniel, L.D., Zhou, X.J., Schultz, R.A., Wakeland, E.K. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  2. Transplantation of gene-modified human bone marrow stromal cells into mouse-human bone chimeras. Brouard, N., Chapel, A., Thierry, D., Charbord, P., Péault, B. J. Hematother. Stem Cell Res. (2000) [Pubmed]
  3. Selective activation of gamma/delta + T cell clones by single anti-CD2 antibodies. Wesselborg, S., Janssen, O., Pechhold, K., Kabelitz, D. J. Exp. Med. (1991) [Pubmed]
  4. Interactions between lymphocytes and dermal fibroblasts: an in vitro model of cutaneous lymphocyte trafficking. Abraham, D., Bokth, S., Bou-Gharios, G., Beauchamp, J., Olsen, I. Exp. Cell Res. (1990) [Pubmed]
  5. CD2 antigen targeting reduces intragraft expression of mRNA-encoding granzyme B and IL-10 and induces tolerance. Kapur, S., Khanna, A., Sharma, V.K., Li, B., Suthanthiran, M. Transplantation (1996) [Pubmed]
  6. The murine homologue of the T lymphocyte CD2 antigen: molecular cloning, chromosome assignment and cell surface expression. Sewell, W.A., Brown, M.H., Owen, M.J., Fink, P.J., Kozak, C.A., Crumpton, M.J. Eur. J. Immunol. (1987) [Pubmed]
  7. T cell receptor gene rearrangements in cells with natural killer activity in the mouse. Lauzon, R.J., Siminovitch, K.A., Roder, J.C. Immunol. Res. (1986) [Pubmed]
  8. Enhancing effects of autologous erythrocytes on human or mouse cytokine secretion and IL-2R expression. Kalechman, Y., Herman, S., Gafter, U., Sredni, B. Cell. Immunol. (1993) [Pubmed]
  9. Identical forms of the CD2 antigen expressed by mouse T and B lymphocytes. Altevogt, P., Michaelis, M., Kyewski, B. Eur. J. Immunol. (1989) [Pubmed]
  10. Antibody 12-15 cross-reacts with mouse Fc gamma receptors and CD2: study of thymus expression, genetic polymorphism and biosynthesis of the CD2 protein. Altevogt, P., Kohl, U., Von Hoegen, P., Lang, E., Schirrmacher, V. Eur. J. Immunol. (1989) [Pubmed]
  11. Identification of a new surface molecule expressed by human LGL and LAK cells production of a specific monoclonal antibody and comparison with other NK/LAK markers. Zocchi, M.R., Poggi, A., Mariani, S., Gianazza, E., Rugarli, C. Cell. Immunol. (1989) [Pubmed]
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