Gene Review:
Pck1 - phosphoenolpyruvate carboxykinase 1,...
Mus musculus
Synonyms:
AI265463, PEPCK, PEPCK-C, Pck-1, Pepck
- Dual specificity MAPK phosphatase 3 activates PEPCK gene transcription and increases gluconeogenesis in rat hepatoma cells. Xu, H., Yang, Q., Shen, M., Huang, X., Dembski, M., Gimeno, R., Tartaglia, L.A., Kapeller, R., Wu, Z. J. Biol. Chem. (2005)
- Hypoglycemia and impaired hepatic glucose production in mice with a deletion of the C/EBPbeta gene. Liu, S., Croniger, C., Arizmendi, C., Harada-Shiba, M., Ren, J., Poli, V., Hanson, R.W., Friedman, J.E. J. Clin. Invest. (1999)
- Mechanisms by which liver-specific PEPCK knockout mice preserve euglycemia during starvation. She, P., Burgess, S.C., Shiota, M., Flakoll, P., Donahue, E.P., Malloy, C.R., Sherry, A.D., Magnuson, M.A. Diabetes (2003)
- Hormonal regulation of chimeric genes containing the phosphoenolpyruvate carboxykinase promoter regulatory region in hepatoma cells infected by murine retroviruses. Hatzoglou, M., Park, E., Wynshaw-Boris, A., Kaung, H.L., Hanson, R.W. J. Biol. Chem. (1988)
- Vitamin A depletion is associated with low phosphoenolpyruvate carboxykinase mRNA levels during late fetal development and at birth in mice. Ghoshal, S., Pasham, S., Odom, D.P., Furr, H.C., McGrane, M.M. J. Nutr. (2003)
- Vitamin A regulates genes involved in hepatic gluconeogenesis in mice: phosphoenolpyruvate carboxykinase, fructose-1,6-bisphosphatase and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase. Shin, D.J., McGrane, M.M. J. Nutr. (1997)
- CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Herzig, S., Long, F., Jhala, U.S., Hedrick, S., Quinn, R., Bauer, A., Rudolph, D., Schutz, G., Yoon, C., Puigserver, P., Spiegelman, B., Montminy, M. Nature (2001)
- Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-beta1 transgenic mice. Clouthier, D.E., Comerford, S.A., Hammer, R.E. J. Clin. Invest. (1997)
- Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. Shimano, H., Horton, J.D., Hammer, R.E., Shimomura, I., Brown, M.S., Goldstein, J.L. J. Clin. Invest. (1996)
- A mutation in the peroxisome proliferator-activated receptor gamma-binding site in the gene for the cytosolic form of phosphoenolpyruvate carboxykinase reduces adipose tissue size and fat content in mice. Olswang, Y., Cohen, H., Papo, O., Cassuto, H., Croniger, C.M., Hakimi, P., Tilghman, S.M., Hanson, R.W., Reshef, L. Proc. Natl. Acad. Sci. U.S.A. (2002)
- The transcription factor CCAAT/enhancer-binding protein beta regulates gluconeogenesis and phosphoenolpyruvate carboxykinase (GTP) gene transcription during diabetes. Arizmendi, C., Liu, S., Croniger, C., Poli, V., Friedman, J.E. J. Biol. Chem. (1999)
- Identification and characterization of a small molecule AMPK activator that treats key components of type 2 diabetes and the metabolic syndrome. Cool, B., Zinker, B., Chiou, W., Kifle, L., Cao, N., Perham, M., Dickinson, R., Adler, A., Gagne, G., Iyengar, R., Zhao, G., Marsh, K., Kym, P., Jung, P., Camp, H.S., Frevert, E. Cell metabolism. (2006)
- Regulation of renal amino acid transporters during metabolic acidosis. Moret, C., Dave, M.H., Schulz, N., Jiang, J.X., Verrey, F., Wagner, C.A. Am. J. Physiol. Renal Physiol. (2007)
- Fertility of transgenic female mice expressing bovine growth hormone or human growth hormone variant genes. Naar, E.M., Bartke, A., Majumdar, S.S., Buonomo, F.C., Yun, J.S., Wagner, T.E. Biol. Reprod. (1991)
- Estrogen-related receptor alpha is a repressor of phosphoenolpyruvate carboxykinase gene transcription. Herzog, B., Cardenas, J., Hall, R.K., Villena, J.A., Budge, P.J., Giguère, V., Granner, D.K., Kralli, A. J. Biol. Chem. (2006)
- The roles of ATF3 in liver dysfunction and the regulation of phosphoenolpyruvate carboxykinase gene expression. Allen-Jennings, A.E., Hartman, M.G., Kociba, G.J., Hai, T. J. Biol. Chem. (2002)
- Transgenic mice overexpressing phosphoenolpyruvate carboxykinase develop non-insulin-dependent diabetes mellitus. Valera, A., Pujol, A., Pelegrin, M., Bosch, F. Proc. Natl. Acad. Sci. U.S.A. (1994)
- PPAR gamma 2 regulates adipose expression of the phosphoenolpyruvate carboxykinase gene. Tontonoz, P., Hu, E., Devine, J., Beale, E.G., Spiegelman, B.M. Mol. Cell. Biol. (1995)
- Transcriptional regulation of the phosphoenolpyruvate carboxykinase gene by cooperation between hepatic nuclear factors. Yanuka-Kashles, O., Cohen, H., Trus, M., Aran, A., Benvenisty, N., Reshef, L. Mol. Cell. Biol. (1994)
- Peroxisome proliferator-activated receptor gamma and chicken ovalbumin upstream promoter transcription factor II negatively regulate the phosphoenolpyruvate carboxykinase promoter via a common element. Eubank, D.W., Duplus, E., Williams, S.C., Forest, C., Beale, E.G. J. Biol. Chem. (2001)
- Salicornia herbacea prevents high fat diet-induced hyperglycemia and hyperlipidemia in ICR mice. Park, S.H., Ko, S.K., Choi, J.G., Chung, S.H. Arch. Pharm. Res. (2006)
- Phosphoenolpyruvate carboxykinase is necessary for the integration of hepatic energy metabolism. She, P., Shiota, M., Shelton, K.D., Chalkley, R., Postic, C., Magnuson, M.A. Mol. Cell. Biol. (2000)
- Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2. Simon, M.F., Daviaud, D., Pradère, J.P., Grès, S., Guigné, C., Wabitsch, M., Chun, J., Valet, P., Saulnier-Blache, J.S. J. Biol. Chem. (2005)
- The transcriptional regulation of phosphoenolpyruvate carboxykinase gene in the kidney requires the HNF-1 binding site of the gene. Cassuto, H., Olswang, Y., Heinemann, S., Sabbagh, K., Hanson, R.W., Reshef, L. Gene (2003)
- Repression and activation of transcription of phosphoenolpyruvate carboxykinase gene during liver development. Cassuto, H., Aran, A., Cohen, H., Eisenberger, C.L., Reshef, L. FEBS Lett. (1999)
- Long-term treatment with novel glycogen synthase kinase-3 inhibitor improves glucose homeostasis in ob/ob mice: molecular characterization in liver and muscle. Kaidanovich-Beilin, O., Eldar-Finkelman, H. J. Pharmacol. Exp. Ther. (2006)
- Retinoid regulation of the phosphoenolpyruvate carboxykinase gene in liver. Shin, D.J., Odom, D.P., Scribner, K.B., Ghoshal, S., McGrane, M.M. Mol. Cell. Endocrinol. (2002)
- Evidence from transgenic mice that myc regulates hepatic glycolysis. Valera, A., Pujol, A., Gregori, X., Riu, E., Visa, J., Bosch, F. FASEB J. (1995)
- Nutrient control of phosphorylation and translocation of Foxo1 in C57BL/6 and db/db mice. Aoyama, H., Daitoku, H., Fukamizu, A. Int. J. Mol. Med. (2006)
- Isolation and characterization of mouse hepatocyte lines carrying a lethal albino deletion. Chou, J.Y., Ruppert, S., Shelly, L.L., Pan, C.J. J. Biol. Chem. (1991)
- Assignment of the rat genes coding for alpha 1-antitrypsin (PI), phosphoenolpyruvate carboxykinase (PEPCK), alcohol dehydrogenase (ADH), and fructose-1,6-bisphosphatase (FDP). Fulchignoni-Lataud, M.C., Szpirer, J., Levan, G., Weiss, M.C. Mamm. Genome (1992)
- Identification of a novel mouse hepatic 52 kDa protein that interacts with the cAMP response element of the rat angiotensinogen gene. Wu, J., Jiang, Q., Chen, X., Wu, X.H., Chan, J.S. Biochem. J. (1998)
- RNA polymerase II association with the phosphoenolpyruvate carboxykinase (PEPCK) promoter is reduced in vitamin A-deficient mice. Scribner, K.B., McGrane, M.M. J. Nutr. (2003)
- Lactotroph hyperplasia in the pituitaries of female mice expressing high levels of bovine growth hormone. Vidal, S., Stefaneanu, L., Thapar, K., Aminyar, R., Kovacs, K., Bartke, A. Transgenic Res. (1999)