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Gene Review

UBB  -  ubiquitin B

Homo sapiens

Synonyms: FLJ25987, MGC8385, Polyubiquitin-B
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Disease relevance of UBB


Psychiatry related information on UBB

  • Here frame-shift ubiquitin-B and amyloid precursor protein were immunochemically shown to exist in the brain of high pathology control (HPC) patients with AD pathology but without prior dementia [6].

High impact information on UBB

  • Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients [7].
  • CONCLUSIONS: The results showed that molecular misreading of the ubiquitin B gene occurred in hepatocytes in virtually all of the MB-containing livers tested [1].
  • Recently, the deposits have been shown to contain protein fragments of ubiquitin-B and amyloid precursor protein (APP) with an aberrant carboxyl terminus resulting from frameshift mutations (dinucleotide deletions; DeltaGU or DeltaGA) in or adjacent to GAGAG motifs in their mRNAs, a process referred to as molecular misreading [8].
  • Appending a portion of the CMV enhancer 5' of the UBB promoter (CMV-Ub) increased CAT expression to nearly that of the CMV promoter and expression persisted in the lung for at least 3 months, with 50% of day 2 levels remaining at day 84 [9].
  • Chloramphenicol acetyltransferase (CAT) reporter gene expression from the UBB promoter was initially very low at day 2 post-administration, but by day 35 exceeded the level of expression attained from a CMV promoter vector by four- to ninefold [9].

Biological context of UBB

  • The UBB and UBC polyubiquitin genes have previously been mapped by the use of specific intron or 5' flanking sequence probes [10].
  • Novel frameshift mutations at a number of locations in the transcripts of the ubiquitin-B and APP genes were discovered (DeltaGA, DeltaG, DeltaGU, DeltaGG, DeltaCA, DeltaAU, DeltaA, DeltaAA, DeltaC, DeltaU, and insertion of an A) [8].

Anatomical context of UBB


Associations of UBB with chemical compounds

  • In N. notopterus the effects of hypercalcaemia (caused by keeping the specimens in 0.5% of CaCl2 solution and by injecting 4000 I.U. of vitamin D2 on alternate days) on UBB has been observed [12].

Other interactions of UBB

  • In this study, we provide additional evidence for this relationship, by demonstrating that SMECE stain strongly positive for p63, which is a new marker for UBB/solid cell nests [3].


  1. Molecular misreading of the ubiquitin B gene and hepatic mallory body formation. McPhaul, L.W., Wang, J., Hol, E.M., Sonnemans, M.A., Riley, N., Nguyen, V., Yuan, Q.X., Lue, Y.H., Van Leeuwen, F.W., French, S.W. Gastroenterology (2002) [Pubmed]
  2. Molecular misreading: a new type of transcript mutation expressed during aging. van Leeuwen, F.W., Fischer, D.F., Kamel, D., Sluijs, J.A., Sonnemans, M.A., Benne, R., Swaab, D.F., Salehi, A., Hol, E.M. Neurobiol. Aging (2000) [Pubmed]
  3. p63 expression in sclerosing mucoepidermoid carcinomas with eosinophilia arising in the thyroid. Hunt, J.L., LiVolsi, V.A., Barnes, E.L. Mod. Pathol. (2004) [Pubmed]
  4. Studies of ultimobranchial body of Rana cyanophlyctis in response to experimental hypercalcaemia. Swarup, K., Krishna, L. Zeitschrift für mikroskopisch-anatomische Forschung. (1980) [Pubmed]
  5. The potential role of ribosomal frameshifting in generating aberrant proteins implicated in neurodegenerative diseases. Wills, N.M., Atkins, J.F. RNA (2006) [Pubmed]
  6. The temporal localization of frame-shift ubiquitin-B and amyloid precursor protein, and complement proteins in the brain of non-demented control patients with increasing Alzheimer's disease pathology. Konishi, Y., Beach, T., Sue, L.I., Hampel, H., Lindholm, K., Shen, Y. Neurosci. Lett. (2003) [Pubmed]
  7. Frameshift mutants of beta amyloid precursor protein and ubiquitin-B in Alzheimer's and Down patients. van Leeuwen, F.W., de Kleijn, D.P., van den Hurk, H.H., Neubauer, A., Sonnemans, M.A., Sluijs, J.A., Köycü, S., Ramdjielal, R.D., Salehi, A., Martens, G.J., Grosveld, F.G., Peter, J., Burbach, H., Hol, E.M. Science (1998) [Pubmed]
  8. Novel frameshift mutations near short simple repeats. van Den Hurk, W.H., Willems, H.J., Bloemen, M., Martens, G.J. J. Biol. Chem. (2001) [Pubmed]
  9. High and sustained transgene expression in vivo from plasmid vectors containing a hybrid ubiquitin promoter. Yew, N.S., Przybylska, M., Ziegler, R.J., Liu, D., Cheng, S.H. Mol. Ther. (2001) [Pubmed]
  10. Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12. Webb, G.C., Baker, R.T., Coggan, M., Board, P.G. Genomics (1994) [Pubmed]
  11. Neurofibrillary tangles in progressive supranuclear palsy brains exhibit immunoreactivity to frameshift mutant ubiquitin-B protein. Fergusson, J., Landon, M., Lowe, J., Ward, L., van Leeuwen, F.W., Mayer, R.J. Neurosci. Lett. (2000) [Pubmed]
  12. Ultimobranchial body of Notopterus notopterus in relation to calcium and sodium rich environments. Swarup, K., Ahmad, N. Zeitschrift für mikroskopisch-anatomische Forschung. (1979) [Pubmed]
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