Gene Review:
TP63 - tumor protein p63
Homo sapiens
Synonyms:
AIS, B(p51A), B(p51B), CUSP, Chronic ulcerative stomatitis protein, ...
Pruneri,
Fabris,
Dell'Orto,
Biasi,
Valentini,
Del Curto,
Laszlo,
Cattaneo,
Fasani,
Rossini,
Manzotti,
Bertolini,
Martinelli,
Neri,
Viale,
Streelman,
Webb,
Albertson,
Kocher,
Cho,
Kim,
Park,
Kim,
Park,
Song,
Kaelin,
Saito,
Kawakami,
Okada,
Takazawa,
Koga,
Kageyama,
Kihara,
Thurfjell,
Coates,
Vojtesek,
Benham-Motlagh,
Eisold,
Nylander,
Klein,
Georges,
Künkele,
Huber,
Engh,
Hansen,
Kim,
Do,
Park,
- P73 expression in basal layers of head and neck squamous epithelium: a role in differentiation and carcinogenesis in concert with p53 and p63? Faridoni-Laurens, L., Bosq, J., Janot, F., Vayssade, M., Le Bihan, M.L., Kaghad, M., Caput, D., Bénard, J., Ahomadegbe, J.C. Oncogene (2001)
- The transactivating isoforms of p63 are overexpressed in high-grade follicular lymphomas independent of the occurrence of p63 gene amplification. Pruneri, G., Fabris, S., Dell'Orto, P., Biasi, M.O., Valentini, S., Del Curto, B., Laszlo, D., Cattaneo, L., Fasani, R., Rossini, L., Manzotti, M., Bertolini, F., Martinelli, G., Neri, A., Viale, G. J. Pathol. (2005)
- Loss of p63 and cytokeratin 5/6 expression is associated with more aggressive tumors in endometrial carcinoma patients. Stefansson, I.M., Salvesen, H.B., Akslen, L.A. Int. J. Cancer (2006)
- Point mutations in the tyrosine aminotransferase gene in tyrosinemia type II. Natt, E., Kida, K., Odievre, M., Di Rocco, M., Scherer, G. Proc. Natl. Acad. Sci. U.S.A. (1992)
- Repeated long separations from pups produce depression-like behavior in rat mothers. Boccia, M.L., Razzoli, M., Prasad Vadlamudi, S., Trumbull, W., Caleffie, C., Pedersen, C.A. Psychoneuroendocrinology (2007)
- The cusp of evolution and development: a model of cichlid tooth shape diversity. Streelman, J.T., Webb, J.F., Albertson, R.C., Kocher, T.D. Evol. Dev. (2003)
- Lateralization of verbal memory and unilateral hippocampal sclerosis: evidence of task-specific effects. Saling, M.M., Berkovic, S.F., O'Shea, M.F., Kalnins, R.M., Darby, D.G., Bladin, P.F. Journal of clinical and experimental neuropsychology : official journal of the International Neuropsychological Society. (1993)
- Heterozygous germline mutations in the p53 homolog p63 are the cause of EEC syndrome. Celli, J., Duijf, P., Hamel, B.C., Bamshad, M., Kramer, B., Smits, A.P., Newbury-Ecob, R., Hennekam, R.C., Van Buggenhout, G., van Haeringen, A., Woods, C.G., van Essen, A.J., de Waal, R., Vriend, G., Haber, D.A., Yang, A., McKeon, F., Brunner, H.G., van Bokhoven, H. Cell (1999)
- Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Osada, M., Ohba, M., Kawahara, C., Ishioka, C., Kanamaru, R., Katoh, I., Ikawa, Y., Nimura, Y., Nakagawara, A., Obinata, M., Ikawa, S. Nat. Med. (1998)
- p63 regulates proliferation and differentiation of developmentally mature keratinocytes. Truong, A.B., Kretz, M., Ridky, T.W., Kimmel, R., Khavari, P.A. Genes Dev. (2006)
- P73 functionally replaces p53 in Adriamycin-treated, p53-deficient breast cancer cells. Vayssade, M., Haddada, H., Faridoni-Laurens, L., Tourpin, S., Valent, A., Bénard, J., Ahomadegbe, J.C. Int. J. Cancer (2005)
- Expression of p63 in primary cutaneous adnexal neoplasms and adenocarcinoma metastatic to the skin. Ivan, D., Hafeez Diwan, A., Prieto, V.G. Mod. Pathol. (2005)
- p63 Immunohistochemistry in the distinction of adenoid cystic carcinoma from basaloid squamous cell carcinoma. Emanuel, P., Wang, B., Wu, M., Burstein, D.E. Mod. Pathol. (2005)
- P63 is expressed in basal and myoepithelial cells of human normal and tumor salivary gland tissues. Bilal, H., Handra-Luca, A., Bertrand, J.C., Fouret, P.J. J. Histochem. Cytochem. (2003)
- Expression of the GLUT1 glucose transporter, p63 and p53 in thyroid carcinomas. Kim, Y.W., Do, I.G., Park, Y.K. Pathol. Res. Pract. (2006)
- The emerging p53 gene family. Kaelin, W.G. J. Natl. Cancer Inst. (1999)
- TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria. Gressner, O., Schilling, T., Lorenz, K., Schulze Schleithoff, E., Koch, A., Schulze-Bergkamen, H., Maria Lena, A., Candi, E., Terrinoni, A., Valeria Catani, M., Oren, M., Melino, G., Krammer, P.H., Stremmel, W., Müller, M. EMBO J. (2005)
- DNA-binding and transactivation activities are essential for TAp63 protein degradation. Ying, H., Chang, D.L., Zheng, H., McKeon, F., Xiao, Z.X. Mol. Cell. Biol. (2005)
- Mutational analysis of the p63/p73L/p51/p40/CUSP/KET gene in human cancer cell lines using intronic primers. Hagiwara, K., McMenamin, M.G., Miura, K., Harris, C.C. Cancer Res. (1999)
- p51/p63 Controls subunit alpha3 of the major epidermis integrin anchoring the stem cells to the niche. Kurata, S., Okuyama, T., Osada, M., Watanabe, T., Tomimori, Y., Sato, S., Iwai, A., Tsuji, T., Ikawa, Y., Katoh, I. J. Biol. Chem. (2004)
- Spatial and isoform specific p63 expression in the male human urogenital tract. Saito, K., Kawakami, S., Okada, Y., Takazawa, R., Koga, F., Kageyama, Y., Kihara, K. J. Urol. (2006)
- Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells. Chen, Z., Evans, W.H., Pflugfelder, S.C., Li, D.Q. Stem Cells (2006)
- Endogenous p63 acts as a survival factor for tumour cells of SCCHN origin. Thurfjell, N., Coates, P.J., Vojtesek, B., Benham-Motlagh, P., Eisold, M., Nylander, K. Int. J. Mol. Med. (2005)
- p63 expression in benign and malignant breast lesions. Stefanou, D., Batistatou, A., Nonni, A., Arkoumani, E., Agnantis, N.J. Histol. Histopathol. (2004)
- Inhibition of epidermal growth factor receptor signaling decreases p63 expression in head and neck squamous carcinoma cells. Matheny, K.E., Barbieri, C.E., Sniezek, J.C., Arteaga, C.L., Pietenpol, J.A. Laryngoscope (2003)
- High thermostability and lack of cooperative DNA binding distinguish the p63 core domain from the homologous tumor suppressor p53. Klein, C., Georges, G., Künkele, K.P., Huber, R., Engh, R.A., Hansen, S. J. Biol. Chem. (2001)
- Complex p63 mRNA isoform expression patterns in squamous cell carcinoma of the head and neck. Thurfjell, N., Coates, P.J., Uusitalo, T., Mahani, D., Dabelsteen, E., Dahlqvist, A., Sjöström, B., Roos, G., Nylander, K. Int. J. Oncol. (2004)
- P63 expression in papillary and anaplastic carcinomas of the thyroid gland: lack of an oncogenetic role in tumorigenesis and progression. Preto, A., Reis-Filho, J.S., Ricardo, S., Soares, P. Pathol. Res. Pract. (2002)
- The p53-homologue p63 may promote thyroid cancer progression. Malaguarnera, R., Mandarino, A., Mazzon, E., Vella, V., Gangemi, P., Vancheri, C., Vigneri, P., Aloisi, A., Vigneri, R., Frasca, F. Endocr. Relat. Cancer (2005)
- The human MDM2 oncoprotein increases the transcriptional activity and the protein level of the p53 homolog p63. Calabrò, V., Mansueto, G., Parisi, T., Vivo, M., Calogero, R.A., La Mantia, G. J. Biol. Chem. (2002)
- GPX2, a direct target of p63, inhibits oxidative stress-induced apoptosis in a p53-dependent manner. Yan, W., Chen, X. J. Biol. Chem. (2006)
- p300 regulates p63 transcriptional activity. MacPartlin, M., Zeng, S., Lee, H., Stauffer, D., Jin, Y., Thayer, M., Lu, H. J. Biol. Chem. (2005)
- TAp63gamma can substitute for p53 in inducing expression of the maspin tumor suppressor. Spiesbach, K., Tannapfel, A., Mössner, J., Engeland, K. Int. J. Cancer (2005)
- P63 and EGFR as prognostic predictors in stage IIB radiation-treated cervical squamous cell carcinoma. Cho, N.H., Kim, Y.B., Park, T.K., Kim, G.E., Park, K., Song, K.J. Gynecol. Oncol. (2003)
- A novel response element confers p63- and p73-specific activation of the WNT4 promoter. Osada, M., Park, H.L., Nagakawa, Y., Begum, S., Yamashita, K., Wu, G., Kim, M.S., Trink, B., Sidransky, D. Biochem. Biophys. Res. Commun. (2006)
- CUSP/p63 expression in rat and human tissues. Dellavalle, R.P., Egbert, T.B., Marchbank, A., Su, L.J., Lee, L.A., Walsh, P. J. Dermatol. Sci. (2001)