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Gene Review

UBA7  -  ubiquitin-like modifier activating enzyme 7

Homo sapiens

Synonyms: D8, UBA1B, UBE1L, UBE2, Ubiquitin-activating enzyme 7, ...
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Disease relevance of UBE1L


High impact information on UBE1L


Biological context of UBE1L

  • The UBE1L gene isolated from the chromosome 3p21 region has an extremely reduced level of mRNA in lung cancer [3].
  • The human UBE1L gene, for which the product may well play a role in the ubiquitin system because of its high degree of identity to the ubiquitin activating enzyme, is located at 3p21, a chromosomal region consistently showing loss of heterozygosity in lung cancer [4].

Anatomical context of UBE1L

  • In contrast, UBE1L mRNA expression was markedly repressed in several cancer cell lines [5].
  • Studies done on paraffin-embedded and fixed tissues revealed abundant UBE1L, but low levels of cyclin D1 expression in the normal human bronchial epithelium, indicating an inverse relationship existed between these species [1].
  • 5'-Azacytidine-induced demethylation did not result in a marked increase of the UBE1L mRNA level in the tumor cell lines [4].
  • On D8 and D10 TCDD reduced myocyte proliferation [6].
  • To evaluate effects of TCDD on differentiation of coronary arteries, chick embryo hearts from incubation days 8 (D8), D10, and D12 were stained with anti-alpha-smooth muscle actin [6].

Associations of UBE1L with chemical compounds


Regulatory relationships of UBE1L

  • In a dose-dependent manner, wild-type but not mutant UBE1L species repressed cyclin D1 expression [1].

Other interactions of UBE1L

  • UBE1L is proposed as a direct pharmacological target that overcomes oncogenic effects of PML/RARalpha by triggering its degradation and signaling apoptosis in APL cells [2].
  • A physical association was found between UBE1L and ISG15 in vivo [5].
  • 3. FISH analysis showed that the distance between UBE1L and RBM5 in 3p21.3 is about 265 kb [7].
  • A homologue of UBE1, UBE1L, is located at 3p21 [7].
  • These findings also provide a mechanistic basis for the tumor suppressive effects of UBE1L through cyclin D1 repression [1].

Analytical, diagnostic and therapeutic context of UBE1L

  • Microarray analysis revealed involvement of an E1-like ubiquitin-activating enzyme, UBE1L, in this induction [8].
  • Although proteins that bind to the D8 element appear ubiquitous, this element does yield tissue-specific complexes in mobility shift assays [9].
  • In addition, temporal and spatial patterns of apoptosis were detected by TUNEL on D3, D5, D6, D8, and D10, and immunohistochemistry was used to identify the origin of apoptotic cells on D6 [6].


  1. Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention. Pitha-Rowe, I., Petty, W.J., Feng, Q., Koza-Taylor, P.H., Dimattia, D.A., Pinder, L., Dragnev, K.H., Memoli, N., Memoli, V., Turi, T., Beebe, J., Kitareewan, S., Dmitrovsky, E. Cancer Res. (2004) [Pubmed]
  2. UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Kitareewan, S., Pitha-Rowe, I., Sekula, D., Lowrey, C.H., Nemeth, M.J., Golub, T.R., Freemantle, S.J., Dmitrovsky, E. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  3. The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. McLaughlin, P.M., Helfrich, W., Kok, K., Mulder, M., Hu, S.W., Brinker, M.G., Ruiters, M.H., de Leij, L.F., Buys, C.H. Int. J. Cancer (2000) [Pubmed]
  4. The genomic structure of the human UBE1L gene. Kok, K., Van den Berg, A., Veldhuis, P.M., Franke, M., Terpstra, P., Buys, C.H. Gene Expr. (1995) [Pubmed]
  5. Involvement of UBE1L in ISG15 conjugation during retinoid-induced differentiation of acute promyelocytic leukemia. Pitha-Rowe, I., Hassel, B.A., Dmitrovsky, E. J. Biol. Chem. (2004) [Pubmed]
  6. 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) inhibition of coronary development is preceded by a decrease in myocyte proliferation and an increase in cardiac apoptosis. Ivnitski, I., Elmaoued, R., Walker, M.K. Teratology (2001) [Pubmed]
  7. An evolutionary rearrangement of the Xp11.3-11.23 region in 3p21.3, a region frequently deleted in a variety of cancers. Timmer, T., Terpstra, P., van den Berg, A., Veldhuis, P.M., Ter Elst, A., van der Veen, A.Y., Kok, K., Naylor, S.L., Buys, C.H. Genomics (1999) [Pubmed]
  8. Retinoid targets in cancer therapy and chemoprevention. Dragnev, K.H., Petty, W.J., Dmitrovsky, E. Cancer Biol. Ther. (2003) [Pubmed]
  9. A possible role for D8/PSF-A-like sequences in lactotroph versus somatotroph expression of the human prolactin gene. Leite, V., Cardoso, E.A., Bock, M.E., Sobrinho, L.G., Cattini, P.A. J. Endocrinol. (1996) [Pubmed]
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