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Gene Review

ATG7  -  autophagy related 7

Homo sapiens

Synonyms: APG7-LIKE, APG7-like, APG7L, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, ...
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Disease relevance of ATG7


High impact information on ATG7

  • Various Ca(2+) mobilizing agents (vitamin D(3) compounds, ionomycin, ATP, and thapsigargin) inhibit the activity of mammalian target of rapamycin, a negative regulator of macroautophagy, and induce massive accumulation of autophagosomes in a Beclin 1- and Atg7-dependent manner [3].
  • Recent studies examining cells lacking the autophagy genes Atg5 and Atg7 have demonstrated that autophagy plays essential roles in cell survival during starvation, in innate cell clearance of microbial pathogens, and in neural cell maintenance [4].
  • Inhibition of autophagy by chemical compounds or knocking down the expression of key autophagy proteins such as ATG7, ATG8, and receptor interacting protein (RIP) blocks ROS accumulation and cell death [5].
  • Several candidate TSGs within these frequently detected LOH regions have been found, including APG7L at 3p25.3, CLASP2 at 3p23, and CACNA2D3 at 3p21 [6].
  • One interferon-stimulated gene of particular interest was UBE1L, the ubiquitin-activating enzyme E1-like protein [7].

Biological context of ATG7

  • Therefore, we propose that GSA7 is not required for initiation of autophagy but is required for bringing the opposing vacuolar membranes together for homotypic fusion, thereby completing peroxisome sequestration [8].
  • The knockout mutant gsa7Delta had an identical phenotype to gsa7, and both mutants were rescued by an epitope-tagged Gsa7p (Gsa7-hemagglutinin [HA]) [8].
  • Th2 cells become more resistant to growth factor-withdrawal cell death when autophagy is blocked using either chemical inhibitors 3-methyladenine, or by RNA interference knockdown of beclin 1 and Atg7 [9].

Anatomical context of ATG7


Associations of ATG7 with chemical compounds

  • Upon glucose adaptation, gsa7 cells were unable to degrade peroxisomal alcohol oxidase [8].

Other interactions of ATG7

  • Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3 [11].


  1. The ubiquitin-activating enzyme E1-like protein in lung cancer cell lines. McLaughlin, P.M., Helfrich, W., Kok, K., Mulder, M., Hu, S.W., Brinker, M.G., Ruiters, M.H., de Leij, L.F., Buys, C.H. Int. J. Cancer (2000) [Pubmed]
  2. Macrophages rapidly transfer pathogens from lipid raft vacuoles to autophagosomes. Amer, A.O., Byrne, B.G., Swanson, M.S. Autophagy. (2005) [Pubmed]
  3. Control of macroautophagy by calcium, calmodulin-dependent kinase kinase-beta, and Bcl-2. Høyer-Hansen, M., Bastholm, L., Szyniarowski, P., Campanella, M., Szabadkai, G., Farkas, T., Bianchi, K., Fehrenbacher, N., Elling, F., Rizzuto, R., Mathiasen, I.S., Jäättelä, M. Mol. Cell (2007) [Pubmed]
  4. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. Pua, H.H., Dzhagalov, I., Chuck, M., Mizushima, N., He, Y.W. J. Exp. Med. (2007) [Pubmed]
  5. Autophagic programmed cell death by selective catalase degradation. Yu, L., Wan, F., Dutta, S., Welsh, S., Liu, Z., Freundt, E., Baehrecke, E.H., Lenardo, M. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  6. High-throughput loss-of-heterozygosity study of chromosome 3p in lung cancer using single-nucleotide polymorphism markers. Tai, A.L., Mak, W., Ng, P.K., Chua, D.T., Ng, M.Y., Fu, L., Chu, K.K., Fang, Y., Qiang Song, Y., Chen, M., Zhang, M., Sham, P.C., Guan, X.Y. Cancer Res. (2006) [Pubmed]
  7. Microarray analyses uncover UBE1L as a candidate target gene for lung cancer chemoprevention. Pitha-Rowe, I., Petty, W.J., Feng, Q., Koza-Taylor, P.H., Dimattia, D.A., Pinder, L., Dragnev, K.H., Memoli, N., Memoli, V., Turi, T., Beebe, J., Kitareewan, S., Dmitrovsky, E. Cancer Res. (2004) [Pubmed]
  8. Glucose-induced autophagy of peroxisomes in Pichia pastoris requires a unique E1-like protein. Yuan, W., Stromhaug, P.E., Dunn, W.A. Mol. Biol. Cell (1999) [Pubmed]
  9. Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death. Li, C., Capan, E., Zhao, Y., Zhao, J., Stolz, D., Watkins, S.C., Jin, S., Lu, B. J. Immunol. (2006) [Pubmed]
  10. Autophagy is involved in T cell death after binding of HIV-1 envelope proteins to CXCR4. Espert, L., Denizot, M., Grimaldi, M., Robert-Hebmann, V., Gay, B., Varbanov, M., Codogno, P., Biard-Piechaczyk, M. J. Clin. Invest. (2006) [Pubmed]
  11. Atg8L/Apg8L is the fourth mammalian modifier of mammalian Atg8 conjugation mediated by human Atg4B, Atg7 and Atg3. Tanida, I., Sou, Y.S., Minematsu-Ikeguchi, N., Ueno, T., Kominami, E. FEBS J. (2006) [Pubmed]
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