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Gene Review

Atg7  -  autophagy related 7

Mus musculus

Synonyms: 1810013K23Rik, APG7-like, ATG12-activating enzyme E1 ATG7, Agp7, Apg7l, ...
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Disease relevance of Atg7

  • When compared with autophagosomes stimulated by rapamycin, Legionella vacuoles acquired Atg7, Atg8 and MDC more slowly, and Atg8 processing was also delayed [1].

High impact information on Atg7


Anatomical context of Atg7

  • The autophagy machinery responded to 10-30 kDa species released into culture supernatants by Type IV secretion-competent Legionella, as judged by the macrophages' processing of Atg8 and formation of vacuoles that sequentially acquired Atg7, Atg8 and MDC [1].


  1. Autophagy is an immediate macrophage response to Legionella pneumophila. Amer, A.O., Swanson, M.S. Cell. Microbiol. (2005) [Pubmed]
  2. A critical role for the autophagy gene Atg5 in T cell survival and proliferation. Pua, H.H., Dzhagalov, I., Chuck, M., Mizushima, N., He, Y.W. J. Exp. Med. (2007) [Pubmed]
  3. Autophagy Is Induced in CD4+ T Cells and Important for the Growth Factor-Withdrawal Cell Death. Li, C., Capan, E., Zhao, Y., Zhao, J., Stolz, D., Watkins, S.C., Jin, S., Lu, B. J. Immunol. (2006) [Pubmed]
  4. Loss of autophagy in the central nervous system causes neurodegeneration in mice. Komatsu, M., Waguri, S., Chiba, T., Murata, S., Iwata, J., Tanida, I., Ueno, T., Koike, M., Uchiyama, Y., Kominami, E., Tanaka, K. Nature (2006) [Pubmed]
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