Gene Review:
ATG7 - Atg7p
Saccharomyces cerevisiae S288c
Synonyms:
APG11, APG7, ATG12-activating enzyme E1 ATG7, Autophagy-related protein 7, CVT2, ...
- Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. Komatsu, M., Waguri, S., Ueno, T., Iwata, J., Murata, S., Tanida, I., Ezaki, J., Mizushima, N., Ohsumi, Y., Uchiyama, Y., Kominami, E., Tanaka, K., Chiba, T. J. Cell Biol. (2005)
- The reversible modification regulates the membrane-binding state of Apg8/Aut7 essential for autophagy and the cytoplasm to vacuole targeting pathway. Kirisako, T., Ichimura, Y., Okada, H., Kabeya, Y., Mizushima, N., Yoshimori, T., Ohsumi, M., Takao, T., Noda, T., Ohsumi, Y. J. Cell Biol. (2000)
- Autophagic nutrient recycling in Arabidopsis directed by the ATG8 and ATG12 conjugation pathways. Thompson, A.R., Doelling, J.H., Suttangkakul, A., Vierstra, R.D. Plant Physiol. (2005)
- Apg7p/Cvt2p: A novel protein-activating enzyme essential for autophagy. Tanida, I., Mizushima, N., Kiyooka, M., Ohsumi, M., Ueno, T., Ohsumi, Y., Kominami, E. Mol. Biol. Cell (1999)
- The C-terminal region of an Apg7p/Cvt2p is required for homodimerization and is essential for its E1 activity and E1-E2 complex formation. Komatsu, M., Tanida, I., Ueno, T., Ohsumi, M., Ohsumi, Y., Kominami, E. J. Biol. Chem. (2001)
- Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast. Shintani, T., Mizushima, N., Ogawa, Y., Matsuura, A., Noda, T., Ohsumi, Y. EMBO J. (1999)
- Apg7p/Cvt2p is required for the cytoplasm-to-vacuole targeting, macroautophagy, and peroxisome degradation pathways. Kim, J., Dalton, V.M., Eggerton, K.P., Scott, S.V., Klionsky, D.J. Mol. Biol. Cell (1999)
- Murine Apg12p has a substrate preference for murine Apg7p over three Apg8p homologs. Tanida, I., Tanida-Miyake, E., Nishitani, T., Komatsu, M., Yamazaki, H., Ueno, T., Kominami, E. Biochem. Biophys. Res. Commun. (2002)
- Excess peroxisomes are degraded by autophagic machinery in mammals. Iwata, J., Ezaki, J., Komatsu, M., Yokota, S., Ueno, T., Tanida, I., Chiba, T., Tanaka, K., Kominami, E. J. Biol. Chem. (2006)
- Ald6p is a preferred target for autophagy in yeast, Saccharomyces cerevisiae. Onodera, J., Ohsumi, Y. J. Biol. Chem. (2004)
- The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3. Tanida, I., Tanida-Miyake, E., Ueno, T., Kominami, E. J. Biol. Chem. (2001)
- Macroautophagy is required for multicellular development of the social amoeba Dictyostelium discoideum. Otto, G.P., Wu, M.Y., Kazgan, N., Anderson, O.R., Kessin, R.H. J. Biol. Chem. (2003)