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Gene Review

RNF103  -  ring finger protein 103

Homo sapiens

Synonyms: E3 ubiquitin-protein ligase RNF103, HKF-1, KF-1, KF1, RING finger protein 103, ...
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Disease relevance of RNF103


High impact information on RNF103

  • This study has demonstrated antigenic alterations within each ultrastructural subregion of papulonodular basal cell carcinoma tumor nest basement membranes by identifying the virtual absence of C3d,g (sublamina densa) as well as a significant reduction in KF-1 (lamina densa) and bullous pemphigoid (lamina lucida) antigens [3].
  • Prenatal diagnosis is now possible for junctional and recessive dystrophic forms of epidermolysis bullosa (EB); however, there is no similar published experience for dominant dystrophic EB, although data with KF-1 monoclonal antibody suggests that both forms of dystrophic EB can be identified at least postnatally with this unique probe [4].
  • Biochemical characterization of the epithelial basement membrane antigen defined by the monoclonal antibody KF-1 [2].
  • KF-1 antigen is first expressed when the epidermis is further stratified, hemidesmosomes and anchoring fibrils are present in greater numbers and with increased frequency at the dermal-epidermal junction, and hair follicles have begun to bud downward from the basal layer of the epidermis [6].
  • Immunoelectron microscopic studies of normal human skin and esophagus showed specific binding of KF-1 to the lamina densa of the BMZ, a localization identical to that of type IV collagen [7].

Chemical compound and disease context of RNF103

  • We employed the recent development of surface-enhanced laser desorption/ionization ProteinChip technology to measure protein expression in three human ovarian cancer cell lines (KF-1, MN-1, and A2780) and their sublines (KF-r, MN-r, and A2780cp) resistant to cisplatin [8].

Biological context of RNF103


Analytical, diagnostic and therapeutic context of RNF103

  • We now report our experience with light microscopy, electron microscopy, immunofluorescence mapping, and KF-1 and LH 7:2 monoclonal antibodies, in both a mother with dominant dystrophic EB and her fetus at risk, and in a fetus previously shown to be affected with recessive dystrophic EB [4].


  1. KF-1 monoclonal antibody defines a specific basement membrane antigen defect in dystrophic forms of epidermolysis bullosa. Fine, J.D., Breathnach, S.M., Hintner, H., Katz, S.I. J. Invest. Dermatol. (1984) [Pubmed]
  2. Biochemical characterization of the epithelial basement membrane antigen defined by the monoclonal antibody KF-1. Bernard, B.A. J. Invest. Dermatol. (1986) [Pubmed]
  3. Defective expression of basement membrane-associated C3d,g in papulonodular basal cell carcinomas. Basset-Séguin, N., Uhle, P., Emanuel, D., Henry, P., Yancey, K.B. J. Invest. Dermatol. (1989) [Pubmed]
  4. Prenatal diagnosis of dominant and recessive dystrophic epidermolysis bullosa: application and limitations in the use of KF-1 and LH 7:2 monoclonal antibodies and immunofluorescence mapping technique. Fine, J.D., Eady, R.A., Levy, M.L., Hejtmancik, J.F., Courtney, K.B., Carpenter, R.J., Holbrook, K.A., Hawkins, H.K. J. Invest. Dermatol. (1988) [Pubmed]
  5. The dsbB gene product is required for protease production by Burkholderia cepacia. Abe, M., Nakazawa, T. Infect. Immun. (1996) [Pubmed]
  6. The appearance of four basement membrane zone antigens in developing human fetal skin. Fine, J.D., Smith, L.T., Holbrook, K.A., Katz, S.I. J. Invest. Dermatol. (1984) [Pubmed]
  7. A unique epithelial basement membrane antigen defined by a monoclonal antibody (KF-1). Breathnach, S.M., Fox, P.A., Neises, G.R., Stanley, J.R., Katz, S.I. J. Invest. Dermatol. (1983) [Pubmed]
  8. Profiling of proteins associated with cisplatin resistance in ovarian cancer cells. Zhu, K., Fukasawa, I., Fujinoki, M., Furuno, M., Inaba, F., Yamazaki, T., Kamemori, T., Kousaka, N., Ota, Y., Hayashi, M., Maehama, T., Inaba, N. Int. J. Gynecol. Cancer (2005) [Pubmed]
  9. Cloning of human and mouse cDNAs encoding novel zinc finger proteins expressed in cerebellum and hippocampus. Yasojima, K., Tsujimura, A., Mizuno, T., Shigeyoshi, Y., Inazawa, J., Kikuno, R., Kuma, K., Ohkubo, K., Hosokawa, Y., Ibata, Y., Abe, T., Miyata, T., Matsubara, K., Nakajima, K., Hashimoto-Gotoh, T. Biochem. Biophys. Res. Commun. (1997) [Pubmed]
  10. Plasmid elimination and immunomodulation by 3-benzazepines in vitro. Motohashi, N., Kawase, M., Saito, S., Miskolci, C., Berek, L., Molnár, J. Anticancer Res. (1999) [Pubmed]
  11. UVC-protective effect of caffeic acid on normal and transformed human skin cells in vitro. Neradil, J., Veselská, R., Slanina, J. Folia Biol. (Praha) (2003) [Pubmed]
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