The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

FCRL2  -  Fc receptor-like 2

Homo sapiens

Synonyms: CD307b, FCRH2, Fc receptor homolog 2, Fc receptor-like protein 2, FcR-like protein 2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of FCRL2


High impact information on FCRL2

  • In healthy individuals, IRTA4/FcRH2 protein expression was associated with a CD19+CD27+ memory cell phenotype [2].
  • FcRH2/IRTA4 was expressed preferentially in memory B cells [3].
  • The model comprised CHObeta2 SPAP cells; Chinese hamster ovary cells expressing human beta2 adrenoceptors and a secreted placental alkaline phosphatase (SPAP) reporter gene with multiple cAMP response elements (CREs) in its promoter region [4].
  • SPAP assays showed DMI to inhibit isoprenaline or forskolin-enhanced gene transcription in a time and concentration-dependent manner (IC50=16.6+/-2.0 microM after 18 h) [4].
  • By transfection analysis with a plasmid containing the -614/+804 human apoE gene fused to the secreted placental alkaline phosphatase (SPAP) reporter gene, we showed that the SPAP activity was decreased by 50% when HepG2 cells were incubated in the presence of db-cAMP or forskolin, indicating that this promoter region mediated this negative effect [5].

Biological context of FCRL2

  • Sequence alignment with the genomic database revealed that the SPAP1 gene contains seven exons and is localized at chromosome 1q21 [6].
  • Using transfection analysis with a plasmid construct containing the -1378/+11 apo A-I promoter fused to the secreted placental alkaline phosphatase (SPAP) reporter gene, we showed that the SPAP activity was decreased to 50% when Hep G2 cells were incubated in the presence of TPA [7].

Analytical, diagnostic and therapeutic context of FCRL2


  1. Development of an in vitro reporter gene assay to assess xenobiotic induction of the human CYP3A4 gene. Ogg, M.S., Gray, T.J., Gibson, G.G. European journal of drug metabolism and pharmacokinetics. (1997) [Pubmed]
  2. Gene expression signatures separate B-cell chronic lymphocytic leukaemia prognostic subgroups defined by ZAP-70 and CD38 expression status. H??ttmann, A., Klein-Hitpass, L., Thomale, J., Deenen, R., Carpinteiro, A., N??ckel, H., Ebeling, P., F??hrer, A., Edelmann, J., Sellmann, L., D??hrsen, U., D??rig, J. Leukemia (2006) [Pubmed]
  3. Expression pattern of the human FcRH/IRTA receptors in normal tissue and in B-chronic lymphocytic leukemia. Polson, A.G., Zheng, B., Elkins, K., Chang, W., Du, C., Dowd, P., Yen, L., Tan, C., Hongo, J.A., Koeppen, H., Ebens, A. Int. Immunol. (2006) [Pubmed]
  4. The effects of desmethylimipramine on cyclic AMP-stimulated gene transcription in a model cell system. Richards, J.K., Abdel-Razaq, W., Bates, T.E., Kendall, D.A. Biochem. Pharmacol. (2005) [Pubmed]
  5. Transcriptional regulation of apolipoprotein E expression by cyclic AMP. Andreani-Mangeney, M., Vandenbrouck, Y., Janvier, B., Girlich, D., Bereziat, G. FEBS Lett. (1996) [Pubmed]
  6. Molecular cloning and characterization of SPAP1, an inhibitory receptor. Xu , M.J., Zhao, R., Zhao, Z.J. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  7. Transcriptional regulation of apolipoprotein A-I expression in Hep G2 cells by phorbol ester. Vandenbrouck, Y., Lambert, G., Janvier, B., Girlich, D., Bereziat, G., Mangeney-Andreani, M. FEBS Lett. (1995) [Pubmed]
WikiGenes - Universities