Gene Review:
CYP11A1 - cytochrome P450, family 11, subfamily A,...
Homo sapiens
Synonyms:
CYP11A, CYPXIA1, Cholesterol desmolase, Cholesterol side-chain cleavage enzyme, mitochondrial, Cytochrome P450 11A1, ...
- Homozygous mutation of P450 side-chain cleavage enzyme gene (CYP11A1) in 46, XY patient with adrenal insufficiency, complete sex reversal, and agenesis of corpus callosum. al Kandari, H., Katsumata, N., Alexander, S., Rasoul, M.A. J. Clin. Endocrinol. Metab. (2006)
- Autoantibodies against CYP2D6 and other drug-metabolizing enzymes in autoimmune hepatitis type 2. Mizutani, T., Shinoda, M., Tanaka, Y., Kuno, T., Hattori, A., Usui, T., Kuno, N., Osaka, T. Drug Metab. Rev. (2005)
- Molecular genetics of congenital adrenal hyperplasia. White, P.C., New, M.I. Baillieres Clin. Endocrinol. Metab. (1988)
- Microsatellite polymorphism of steroid hormone synthesis gene CYP11A1 is associated with advanced prostate cancer. Kumazawa, T., Tsuchiya, N., Wang, L., Sato, K., Kamoto, T., Ogawa, O., Nakamura, A., Kato, T., Habuchi, T. Int. J. Cancer (2004)
- A pathway for the metabolism of vitamin D3: unique hydroxylated metabolites formed during catalysis with cytochrome P450scc (CYP11A1). Guryev, O., Carvalho, R.A., Usanov, S., Gilep, A., Estabrook, R.W. Proc. Natl. Acad. Sci. U.S.A. (2003)
- MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis. Watari, H., Arakane, F., Moog-Lutz, C., Kallen, C.B., Tomasetto, C., Gerton, G.L., Rio, M.C., Baker, M.E., Strauss, J.F. Proc. Natl. Acad. Sci. U.S.A. (1997)
- Cloning and expression of a cDNA encoding human sterol carrier protein 2. Yamamoto, R., Kallen, C.B., Babalola, G.O., Rennert, H., Billheimer, J.T., Strauss, J.F. Proc. Natl. Acad. Sci. U.S.A. (1991)
- Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta. Chung, B.C., Matteson, K.J., Voutilainen, R., Mohandas, T.K., Miller, W.L. Proc. Natl. Acad. Sci. U.S.A. (1986)
- Association of the steroid synthesis gene CYP11a with polycystic ovary syndrome and hyperandrogenism. Gharani, N., Waterworth, D.M., Batty, S., White, D., Gilling-Smith, C., Conway, G.S., McCarthy, M., Franks, S., Williamson, R. Hum. Mol. Genet. (1997)
- 17 alpha-hydroxylation deficiency. Biglieri, E.G., Kater, C.E. Endocrinol. Metab. Clin. North Am. (1991)
- Activator protein-2 mediates transcriptional activation of the CYP11A1 gene by interaction with Sp1 rather than binding to DNA. Pena, P., Reutens, A.T., Albanese, C., D'Amico, M., Watanabe, G., Donner, A., Shu, I.W., Williams, T., Pestell, R.G. Mol. Endocrinol. (1999)
- The orphan nuclear receptor, liver receptor homolog-1, regulates cholesterol side-chain cleavage cytochrome p450 enzyme in human granulosa cells. Kim, J.W., Havelock, J.C., Carr, B.R., Attia, G.R. J. Clin. Endocrinol. Metab. (2005)
- Genetic linkage mapping of the CYP11A1 gene encoding the cholesterol side-chain cleavage P450scc close to the CYP1A1 gene and D15S204 in the chromosome 15q22.33-q23 region. Durocher, F., Morissette, J., Simard, J. Pharmacogenetics (1998)
- Corticotropin-releasing hormone inhibits progesterone production in cultured human placental trophoblasts. Yang, R., You, X., Tang, X., Gao, L., Ni, X. J. Mol. Endocrinol. (2006)
- Activating protein-1 cooperates with steroidogenic factor-1 to regulate 3',5'-cyclic adenosine 5'-monophosphate-dependent human CYP11A1 transcription in vitro and in vivo. Guo, I.C., Huang, C.Y., Wang, C.K., Chung, B.C. Endocrinology (2007)
- Adrenodoxin (Adx) and CYP11A1 (P450scc) induce apoptosis by the generation of reactive oxygen species in mitochondria. Derouet-Hümbert, E., Roemer, K., Bureik, M. Biol. Chem. (2005)
- Interaction of CYP11B1 (cytochrome P-45011 beta) with CYP11A1 (cytochrome P-450scc) in COS-1 cells. Cao, P.R., Bernhardt, R. Eur. J. Biochem. (1999)
- Identifying susceptibility genes for prostate cancer--a family-based association study of polymorphisms in CYP17, CYP19, CYP11A1, and LH-beta. Douglas, J.A., Zuhlke, K.A., Beebe-Dimmer, J., Levin, A.M., Gruber, S.B., Wood, D.P., Cooney, K.A. Cancer Epidemiol. Biomarkers Prev. (2005)
- Transcriptional regulation of CYP11A1. Guo, I.C., Hu, M.C., Chung, B.C. J. Biomed. Sci. (2003)
- Differentiation of adult stem cells derived from bone marrow stroma into Leydig or adrenocortical cells. Yazawa, T., Mizutani, T., Yamada, K., Kawata, H., Sekiguchi, T., Yoshino, M., Kajitani, T., Shou, Z., Umezawa, A., Miyamoto, K. Endocrinology (2006)
- Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways. Pestell, R.G., Albanese, C., Watanabe, G., Lee, R.J., Lastowiecki, P., Zon, L., Ostrowski, M., Jameson, J.L. Mol. Endocrinol. (1996)
- A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression. Gizard, F., Lavallée, B., DeWitte, F., Hum, D.W. J. Biol. Chem. (2001)
- Modulation of aromatase and P450 cholesterol side-chain cleavage enzyme activities of human placental cytotrophoblasts by insulin and insulin-like growth factor I. Nestler, J.E. Endocrinology (1987)
- Identification of a rat adrenal cytochrome P450 active in polycyclic hydrocarbon metabolism as rat CYP1B1. Demonstration of a unique tissue-specific pattern of hormonal and aryl hydrocarbon receptor-linked regulation. Bhattacharyya, K.K., Brake, P.B., Eltom, S.E., Otto, S.A., Jefcoate, C.R. J. Biol. Chem. (1995)
- Bone morphogenetic protein inhibits ovarian androgen production. Dooley, C.A., Attia, G.R., Rainey, W.E., Moore, D.R., Carr, B.R. J. Clin. Endocrinol. Metab. (2000)
- Molecular cloning and characterization of the cyclic AMP-responsive ovine CYP11A1 (cholesterol side-chain cleavage) gene promoter: DNase 1 protection of conserved consensus elements. Pestell, R.G., Hammond, V.E., Crawford, R.J. J. Mol. Endocrinol. (1993)
- Expression of P450 side-chain cleavage (CYP11A1) and P450 17alpha-hydroxylase-17/20 lyase (CYP17) messenger ribonucleic acid in hamster primary interstitial cells in vitro: differential regulation of steroidogenesis by cyclic adenosine monophosphate. Schwartz, J.R., Roy, S.K. Biol. Reprod. (2000)
- The post-menopausal ovary displays a unique pattern of steroidogenic enzyme expression. Havelock, J.C., Rainey, W.E., Bradshaw, K.D., Carr, B.R. Hum. Reprod. (2006)