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CYP11A1  -  cytochrome P450, family 11, subfamily A,...

Bos taurus

Synonyms: CYP11A, CYPXIA1, P450(scc)
 
 
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Disease relevance of CYP11A1

  • To examine the functional significance of the PR in mitochondrial P450s, we expressed human P450c27 (CYP27) and bovine P450scc (CYP11A1) in an Escherichia coli heterologous expression system, and found that in each one specific proline residue is important for correct folding [1].
 

High impact information on CYP11A1

  • Vasoactive intestinal peptide induces the synthesis of the cholesterol side-chain cleavage enzyme complex in cultured rat ovarian granulosa cells [2].
  • It is concluded that VIP regulates the synthesis of the ovarian cholesterol side-chain cleavage enzyme complex, which catalyzes the rate-limiting reaction in progesterone biosynthesis, and that the VIP effect is at least partially mediated through cAMP [2].
  • VIP-induced synthesis of the cholesterol side-chain cleavage enzyme complex was accompanied by a dose-related increase in cAMP accumulation and progestin formation [2].
  • The origin of steroid hormones in mammals is cholesterol that is metabolized by the mitochondrial CYP11A1 system [3].
  • In addition, variation of the ionic strength in these experiments revealed different optimum salt concentrations for the reduction of adrenodoxin reductase and adrenodoxin, respectively, and unraveled dramatically changing reduction rates of CYP11A1 by adrenodoxin [3].
 

Biological context of CYP11A1

 

Anatomical context of CYP11A1

 

Associations of CYP11A1 with chemical compounds

  • Sequence-alignment studies of the bovine mitochondrial cholesterol side-chain cleavage enzyme cytochrome P-450scc with the bacterial cytochrome P-450cam (camphor hydroxylating enzyme) have been undertaken [13].
  • The adrenodoxin mutants forming the most stable complexes with CYP11A1 show the fastest rates of reduction and the highest rate constants for cholesterol to pregnenolone conversion [5].
  • The results suggest that the C-terminal peptide of adrenodoxin, especially proline 108, affects the structural integrity of the iron-sulfur cluster and that electron donation from adrenodoxin to CYP11A1 and CYP11B1 is determined at least in part by different features of the cytochromes [14].
  • Alpha-branched 1,2-diacyl phosphatidylcholines as effectors of activity of cytochrome P450SCC (CYP11A1). Modeling the structure of the fatty acyl chain region of cardiolipin [15].
  • There was no difference, however, in the ratios of adrenal CYP11A1 mRNA/3beta-hydroxysteroid dehydrogenase/delta5,delta4-isomerase mRNA and CYP21A1 mRNA/18S ribosomal RNA among the N-POMC-(1-77)-, N-POMC-(1-49)-, and saline-infused groups [16].
 

Other interactions of CYP11A1

 

Analytical, diagnostic and therapeutic context of CYP11A1

References

  1. Importance of a proline-rich sequence in the amino-terminal region for correct folding of mitochondrial and soluble microbial p450s. Kusano, K., Kagawa, N., Sakaguchi, M., Omura, T., Waterman, M.R. J. Biochem. (2001) [Pubmed]
  2. Vasoactive intestinal peptide induces the synthesis of the cholesterol side-chain cleavage enzyme complex in cultured rat ovarian granulosa cells. Trzeciak, W.H., Ahmed, C.E., Simpson, E.R., Ojeda, S.R. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  3. Stripping down the mitochondrial cholesterol hydroxylase system, a kinetics study. Schiffler, B., Zöllner, A., Bernhardt, R. J. Biol. Chem. (2004) [Pubmed]
  4. Differentiation-specific action of orphan nuclear receptor NR5A1 (SF-1): transcriptional regulation in luteinizing bovine theca cells. Walther, N., Jansen, M., Akbary, W., Ivell, R. Reprod. Biol. Endocrinol. (2006) [Pubmed]
  5. The interaction of bovine adrenodoxin with CYP11A1 (cytochrome P450scc) and CYP11B1 (cytochrome P45011beta ). Acceleration of reduction and substrate conversion by site-directed mutagenesis of adrenodoxin. Schiffler, B., Kiefer, M., Wilken, A., Hannemann, F., Adolph, H.W., Bernhardt, R. J. Biol. Chem. (2001) [Pubmed]
  6. Phosphorylation of bovine adrenodoxin by protein kinase CK2 affects the interaction with its redox partner cytochrome P450scc (CYP11A1). Bureik, M., Zöllner, A., Schuster, N., Montenarh, M., Bernhardt, R. Biochemistry (2005) [Pubmed]
  7. Conformational dynamics and molecular interaction reactions of recombinant cytochrome p450scc (CYP11A1) detected by fluorescence energy transfer. Lepesheva, G.I., Strushkevich, N.V., Usanov, S.A. Biochim. Biophys. Acta (1999) [Pubmed]
  8. The F-G loop region of cytochrome P450scc (CYP11A1) interacts with the phospholipid membrane. Headlam, M.J., Wilce, M.C., Tuckey, R.C. Biochim. Biophys. Acta (2003) [Pubmed]
  9. Effects of various N-terminal addressing signals on sorting and folding of mammalian CYP11A1 in yeast mitochondria. Kovaleva, I.E., Novikova, L.A., Nazarov, P.A., Grivennikov, S.I., Luzikov, V.N. Eur. J. Biochem. (2003) [Pubmed]
  10. Adrenal P-450scc modulates activity of P-45011 beta in liposomal and mitochondrial membranes. Implication of P-450scc in zone specificity of aldosterone biosynthesis in bovine adrenal. Ikushiro, S., Kominami, S., Takemori, S. J. Biol. Chem. (1992) [Pubmed]
  11. Ultrastructural localization of cytochrome P-450scc in the bovine placentome using protein A-gold technique. Ben-David, E., Shemesh, M. Biol. Reprod. (1990) [Pubmed]
  12. Phosphorylation of purified mitochondrial cytochromes P-450 (cholesterol desmolase and 11 beta-hydroxylase) from bovine adrenal cortex. Defaye, G., Monnier, N., Guidicelli, C., Chambaz, E.M. Mol. Cell. Endocrinol. (1982) [Pubmed]
  13. Molecular modeling of the 3-D structure of cytochrome P-450scc. Vijayakumar, S., Salerno, J.C. Biochim. Biophys. Acta (1992) [Pubmed]
  14. C-terminal region of adrenodoxin affects its structural integrity and determines differences in its electron transfer function to cytochrome P-450. Uhlmann, H., Kraft, R., Bernhardt, R. J. Biol. Chem. (1994) [Pubmed]
  15. Alpha-branched 1,2-diacyl phosphatidylcholines as effectors of activity of cytochrome P450SCC (CYP11A1). Modeling the structure of the fatty acyl chain region of cardiolipin. Schwarz, D., Kisselev, P., Wessel, R., Jueptner, O., Schmid, R.D. J. Biol. Chem. (1996) [Pubmed]
  16. Infusion of N-proopiomelanocortin-(1-77) increases adrenal weight and messenger ribonucleic acid levels of cytochrome P450 17alpha-hydroxylase in the sheep fetus during late gestation. Ross, J.T., Bennett, H.P., James, S., McMillen, I.C. Endocrinology (2000) [Pubmed]
  17. Insulin-like growth factor I enhancement of steroidogenesis by bovine granulosa cells and thecal cells: dependence on de novo cholesterol synthesis. Spicer, L.J., Hamilton, T.D., Keefer, B.E. J. Endocrinol. (1996) [Pubmed]
 
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