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Gene Review

Hcar2  -  hydroxycarboxylic acid receptor 2

Mus musculus

Synonyms: G-protein coupled receptor 109, G-protein coupled receptor 109A, G-protein coupled receptor HM74, Gpr109, Gpr109a, ...
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Disease relevance of Gpr109a


High impact information on Gpr109a


Biological context of Gpr109a


Anatomical context of Gpr109a


Associations of Gpr109a with chemical compounds

  • Here we show that the fatty acid-derived ketone body (D)-beta-hydroxybutyrate ((D)-beta-OHB) specifically activates PUMA-G/HM74a at concentrations observed in serum during fasting [4].

Analytical, diagnostic and therapeutic context of Gpr109a


  1. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Tunaru, S., Kero, J., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., Offermanns, S. Nat. Med. (2003) [Pubmed]
  2. PUMA-G, an IFN-gamma-inducible gene in macrophages is a novel member of the seven transmembrane spanning receptor superfamily. Schaub, A., Fütterer, A., Pfeffer, K. Eur. J. Immunol. (2001) [Pubmed]
  3. GPR109A (PUMA-G/HM74A) mediates nicotinic acid-induced flushing. Benyó, Z., Gille, A., Kero, J., Csiky, M., Suchánková, M.C., Nüsing, R.M., Moers, A., Pfeffer, K., Offermanns, S. J. Clin. Invest. (2005) [Pubmed]
  4. (D)-beta-Hydroxybutyrate inhibits adipocyte lipolysis via the nicotinic acid receptor PUMA-G. Taggart, A.K., Kero, J., Gan, X., Cai, T.Q., Cheng, K., Ippolito, M., Ren, N., Kaplan, R., Wu, K., Wu, T.J., Jin, L., Liaw, C., Chen, R., Richman, J., Connolly, D., Offermanns, S., Wright, S.D., Waters, M.G. J. Biol. Chem. (2005) [Pubmed]
  5. G protein-coupled receptor for nicotinic acid in mouse macrophages. Lorenzen, A., Stannek, C., Burmeister, A., Kalvinsh, I., Schwabe, U. Biochem. Pharmacol. (2002) [Pubmed]
  6. Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74A. Zhang, Y., Schmidt, R.J., Foxworthy, P., Emkey, R., Oler, J.K., Large, T.H., Wang, H., Su, E.W., Mosior, M.K., Eacho, P.I., Cao, G. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
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