The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Rhinitis, Allergic, Seasonal

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Rhinitis, Allergic, Seasonal


Psychiatry related information on Rhinitis, Allergic, Seasonal


High impact information on Rhinitis, Allergic, Seasonal

  • Autoantibodies to beta 2-adrenergic receptors have been identified in the serum of one patient with allergic rhinitis ("hay fever") and two patients with asthma [7].
  • Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany [8].
  • We studied the role of IL-10 in the induction of clinical, cellular, and humoral tolerance during immunotherapy for local mucosal allergy in subjects with seasonal pollinosis [9].
  • Bet v 1 is a 17-kDa protein abundantly present in the pollen of the White birch tree and is the primary cause of birch pollen allergy in humans [10].
  • BACKGROUND: Food allergy to apples, hazelnuts, and celery is frequent in individuals with birch pollen allergy because IgE antibodies specific for the major birch pollen allergen, Bet v 1, cross-react with structurally related allergens in these foods [11].

Chemical compound and disease context of Rhinitis, Allergic, Seasonal

  • The immunoblot results suggest that a 17 kd pollen protein could be a major allergen in patients with Platanus pollinosis [12].
  • The efficacy and safety of loratadine, 40 mg once daily, were compared with terfenadine, 60 mg twice daily, and placebo in controlling symptoms of ragweed hay fever [13].
  • In the patients with seasonal hay fever, the following was observed: basophilic cell CFU-c, measured as basophilic cell or histamine-containing colonies, were significantly reduced during the ragweed season compared to before (p less than 0.005) or after (p less than 0.025) the season in the ragweed-allergic group only [14].
  • Preseasonal IgE ragweed antibody level as a predictor of response to therapy of ragweed hay fever with intranasal cromolyn sodium solution [15].
  • METHODS: Forty-nine patients with histories of birch pollen allergy from the upper and lower airways, positive skin prick test and conjunctival provocation test results, and in vitro specific IgE to birch pollen (Betula verrucosa ) extract were included [16].

Biological context of Rhinitis, Allergic, Seasonal


Anatomical context of Rhinitis, Allergic, Seasonal


Gene context of Rhinitis, Allergic, Seasonal

  • On the other hand, CD86 (B7-2) was significantly upregulated following stimulation in pollinosis subjects (P = 0.02) [26].
  • In combination with the TNF wildtype, the risk for hay fever increased to OR=8.4 (CI: 2.7-25.6) [27].
  • Effect of seasonal exposure to pollen on nonspecific interleukin-4, interleukin-5, and interferon-gamma in vitro release by peripheral blood mononuclear cells from subjects with pollinosis [28].
  • Our morphological study showed that, even before the pollen season, large amounts of IL-4 and IL-1r, exclusive of IL-1 beta, were produced in the nasal tissue of patients with seasonal pollinosis [29].
  • Of this group the 12 RA patients with hay fever were compared with RA patients without hay fever (matched for age, sex, and disease duration) [30].

Analytical, diagnostic and therapeutic context of Rhinitis, Allergic, Seasonal


  1. A 2.8 Mb YAC contig in 11q12-q13 localizes candidate genes for atopy: Fc epsilon RI beta and CD20. Stafford, A.N., Rider, S.H., Hopkin, J.M., Cookson, W.O., Monaco, A.P. Hum. Mol. Genet. (1994) [Pubmed]
  2. HLA-DR2, [HLA-B7, SC31, DR2], and [HLA-B8, SC01, DR3] haplotypes distinguish subjects with asthma from those with rhinitis only in ragweed pollen allergy. Blumenthal, M., Marcus-Bagley, D., Awdeh, Z., Johnson, B., Yunis, E.J., Alper, C.A. J. Immunol. (1992) [Pubmed]
  3. Cutaneous and nasal allergic responses in ragweed hay fever: lack of clinical and histopathologic correlations with late phase reactions. Richerson, H.B., Rajtora, D.W., Penick, G.D., Dick, F.R., Yoo, T.J., Kammermeyer, J.K., Anuras, J.S. J. Allergy Clin. Immunol. (1979) [Pubmed]
  4. Native Art v 1 and recombinant Art v 1 are able to induce humoral and T cell-mediated in vitro and in vivo responses in mugwort allergy. Schmid-Grendelmeier, P., Holzmann, D., Himly, M., Weichel, M., Tresch, S., Rückert, B., Menz, G., Ferreira, F., Blaser, K., Wüthrich, B., Crameri, R. J. Allergy Clin. Immunol. (2003) [Pubmed]
  5. Cetirizine: a review of its use in allergic disorders. Curran, M.P., Scott, L.J., Perry, C.M. Drugs (2004) [Pubmed]
  6. Objective measurement of nasal airway dimensions using acoustic rhinometry: methodological and clinical aspects. Hilberg, O. Allergy (2002) [Pubmed]
  7. Autoantibodies to beta 2-adrenergic receptors: a possible cause of adrenergic hyporesponsiveness in allergic rhinitis and asthma. Venter, J.C., Fraser, C.M., Harrison, L.C. Science (1980) [Pubmed]
  8. Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany. von Mutius, E., Weiland, S.K., Fritzsch, C., Duhme, H., Keil, U. Lancet (1998) [Pubmed]
  9. Grass pollen immunotherapy induces mucosal and peripheral IL-10 responses and blocking IgG activity. Nouri-Aria, K.T., Wachholz, P.A., Francis, J.N., Jacobson, M.R., Walker, S.M., Wilcock, L.K., Staple, S.Q., Aalberse, R.C., Till, S.J., Durham, S.R. J. Immunol. (2004) [Pubmed]
  10. The major birch allergen, Bet v 1, shows affinity for a broad spectrum of physiological ligands. Mogensen, J.E., Wimmer, R., Larsen, J.N., Spangfort, M.D., Otzen, D.E. J. Biol. Chem. (2002) [Pubmed]
  11. Gastrointestinal digestion of Bet v 1-homologous food allergens destroys their mediator-releasing, but not T cell-activating, capacity. Schimek, E.M., Zwölfer, B., Briza, P., Jahn-Schmid, B., Vogel, L., Vieths, S., Ebner, C., Bohle, B. J. Allergy Clin. Immunol. (2005) [Pubmed]
  12. Platanus pollen as an important cause of pollinosis. Varela, S., Subiza, J., Subiza, J.L., Rodríguez, R., García, B., Jerez, M., Jiménez, J.A., Panzani, R. J. Allergy Clin. Immunol. (1997) [Pubmed]
  13. Comparison of the efficacy and safety of loratadine, terfenadine, and placebo in the treatment of seasonal allergic rhinitis. Gutkowski, A., Bedard, P., Del Carpio, J., Hebert, J., Prevost, M., Schulz, J., Turenne, Y., Yeadon, C. J. Allergy Clin. Immunol. (1988) [Pubmed]
  14. Basophilic cell progenitors, nasal metachromatic cells, and peripheral blood basophils in ragweed-allergic patients. Otsuka, H., Dolovich, J., Befus, A.D., Telizyn, S., Bienenstock, J., Denburg, J.A. J. Allergy Clin. Immunol. (1986) [Pubmed]
  15. Preseasonal IgE ragweed antibody level as a predictor of response to therapy of ragweed hay fever with intranasal cromolyn sodium solution. Welsh, P.W., Yunginger, J.W., Kern, E.B., Gleich, G.J. J. Allergy Clin. Immunol. (1977) [Pubmed]
  16. Effect of 2-year placebo-controlled immunotherapy on airway symptoms and medication in patients with birch pollen allergy. Arvidsson, M.B., Löwhagen, O., Rak, S. J. Allergy Clin. Immunol. (2002) [Pubmed]
  17. The effect of cromolyn sodium powder as a treatment for ragweed pollinosis. Leiferman, K.M., Yunginger, J.W., Larson, J.B., Gleich, G.J. J. Allergy Clin. Immunol. (1975) [Pubmed]
  18. Quantitative inhalation bronchial challenge in ragweed hay fevery patients: a comparison with ragweed-allergic asthmatics. Bruce, C.A., Rosenthal, R.R., Lichtenstein, L.M., Norman, P.S. J. Allergy Clin. Immunol. (1975) [Pubmed]
  19. Prolonged bleeding time, reduced platelet aggregation, altered PAF-acether sensitivity and increased platelet mass are a trait of asthma and hay fever. Szczeklik, A., Milner, P.C., Birch, J., Watkins, J., Martin, J.F. Thromb. Haemost. (1986) [Pubmed]
  20. Symptom control in patients with hay fever in UK general practice: how well are we doing and is there a need for allergen immunotherapy? White, P., Smith, H., Baker, N., Davis, W., Frew, A. Clin. Exp. Allergy (1998) [Pubmed]
  21. Investigation of the tendency to wheeze in pollen sensitive patients. Armitage, J.M., Lam, K.S., Wilkinson, I., Faux, J.A., Hopkin, J.M. Clin. Exp. Allergy (1992) [Pubmed]
  22. Albumin, bradykinins, and eosinophil cationic protein on the nasal mucosal surface in patients with hay fever during natural allergen exposure. Svensson, C., Andersson, M., Persson, C.G., Venge, P., Alkner, U., Pipkorn, U. J. Allergy Clin. Immunol. (1990) [Pubmed]
  23. Single amino acid substitutions on a Japanese cedar pollen allergen (Cry j 1)-derived peptide induced alterations in human T cell responses and T cell receptor antagonism. Ikagawa, S., Matsushita, S., Chen, Y.Z., Ishikawa, T., Nishimura, Y. J. Allergy Clin. Immunol. (1996) [Pubmed]
  24. Analysis of sequential immunoglobulin E-binding epitope of Japanese cedar pollen allergen (Cry j 2) in humans, monkeys and mice. Tamura, Y., Kawaguchi, J., Serizawa, N., Hirahara, K., Shiraishi, A., Nigi, H., Taniguchi, Y., Toda, M., Inouye, S., Takemori, T., Sakaguchi, M. Clin. Exp. Allergy (2003) [Pubmed]
  25. Terfenadine exerts antiallergic activity reducing ICAM-1 expression on nasal epithelial cells in patients with pollen allergy. Ciprandi, G., Pronzato, C., Ricca, V., Varese, P., Del Giacco, G.S., Canonica, G.W. Clin. Exp. Allergy (1995) [Pubmed]
  26. The role of costimulatory molecules (B7-1 and B7-2) on allergen-stimulated B cells in cedar pollinosis subjects. Morikawa, H., Nagashima, S. Clin. Exp. Allergy (2000) [Pubmed]
  27. Cross-sectional study on cytokine polymorphisms, cytokine production after T-cell stimulation and clinical parameters in a random sample of a German population. Nieters, A., Brems, S., Becker, N. Hum. Genet. (2001) [Pubmed]
  28. Effect of seasonal exposure to pollen on nonspecific interleukin-4, interleukin-5, and interferon-gamma in vitro release by peripheral blood mononuclear cells from subjects with pollinosis. Muñoz-Bellido, F.J., Monteseirín, F.J., Escribano, M.M., Delgado, J., Velázquez, E., Conde, J. Allergy (1998) [Pubmed]
  29. Pollinosis etiologic relationship between excessive IL-4 production and down-regulation of the inflammation-suppressive system. Urushibata, T., Uesugi, K., Yoshino, K., Kubota, N., Takeyama, I. Acta oto-laryngologica. Supplementum. (1996) [Pubmed]
  30. Mutual antagonism of rheumatoid arthritis and hay fever; a role for type 1/type 2 T cell balance. Verhoef, C.M., van Roon, J.A., Vianen, M.E., Bruijnzeel-Koomen, C.A., Lafeber, F.P., Bijlsma, J.W. Ann. Rheum. Dis. (1998) [Pubmed]
  31. Soybean allergy in patients allergic to birch pollen: clinical investigation and molecular characterization of allergens. Mittag, D., Vieths, S., Vogel, L., Becker, W.M., Rihs, H.P., Helbling, A., Wüthrich, B., Ballmer-Weber, B.K. J. Allergy Clin. Immunol. (2004) [Pubmed]
  32. Differential activation of signal transducer and activator of transcription 6 in B cells from allergic children and their non-allergic siblings. Deveikaite, V., Fila, C., Laurencikiene, J., Klein, E., Kihlström, A., Lilja, G., Ekström, E.S., Severinson, E. Clin. Exp. Allergy (2004) [Pubmed]
  33. Epitope specificity of IgE antibodies to a major allergen (Cry j 1) of Japanese cedar pollen in sera of humans and monkeys with pollinosis. Sakaguchi, M., Hashimoto, M., Nigi, H., Yasueda, H., Takahashi, Y., Watanabe, M., Nagoya, T., Taniguchi, Y., Kurimoto, M., Inouye, S. Immunology (1997) [Pubmed]
  34. Mountain cedar allergens found in nonpollen tree parts. Goetz, D.W., Goetz, M.A., Whisman, B.A. Ann. Allergy Asthma Immunol. (1995) [Pubmed]
WikiGenes - Universities