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Gene Review:

HB-12 - homeobox-leucine zipper protein ATHB-12

Arabidopsis thaliana

Synonyms: ARABIDOPSIS THALIANA HOMEOBOX 12, ATHB-12, ATHB12, homeobox 12

Lee, Y.H. et al., Lee, Y.H. et al., Shin, D. et al.

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Disease relevance of ATHB-12

Taken together, these data suggest that Athb-12 and Athb-7 are members of a related gene family involved in the plant's response to water stress [1].

High impact information on ATHB-12

Treatment with water stress and exogenous abscisic acid (ABA) resulted in the accumulation of Athb-12 mRNA, similar to that of Athb-7 [1].
However, the time course of the Athb-12 response to ABA differed from that of Athb-7, suggesting that both genes, in response to ABA, are regulated in different manners [1].
The deduced amino acid sequence of Athb-12 shows over 80% identity to the Arabidopsis Athb-7 in the homeodomain (82%) and the leucine zipper motif (80%) of the proteins [1].
Athb-12, a homeobox-leucine zipper domain protein from Arabidopsis thaliana, increases salt tolerance in yeast by regulating sodium exclusion [2].
These results suggest that Athb-12 specifically functions in Na+ ion homeostasis in yeast [2].

Chemical compound and disease context of ATHB-12

Taken together, our data suggest that Athb-12 is a transcriptional activator important in regulating certain developmental processes as well as in the plant's response to water stress involving ABA-mediated gene expression [3].

Biological context of ATHB-12

Athb-12 gene expression was further examined using in situ hybridization to determine the cellular distribution of Athb-12 transcripts during ABA induction [3].
The 5' regulatory region of Athb-12 can drive beta-glucuronidase (GUS) expression in tobacco transgenic plants [3].

Analytical, diagnostic and therapeutic context of ATHB-12

To investigate the biological function of Athb-12 in Arabidopsis, we performed Northern blot analysis [2].

References

A new homeodomain-leucine zipper gene from Arabidopsis thaliana induced by water stress and abscisic acid treatment. Lee, Y.H., Chun, J.Y. Plant Mol. Biol. (1998) [Pubmed]
Athb-12, a homeobox-leucine zipper domain protein from Arabidopsis thaliana, increases salt tolerance in yeast by regulating sodium exclusion. Shin, D., Koo, Y.D., Lee, J., Lee, H.J., Baek, D., Lee, S., Cheon, C.I., Kwak, S.S., Lee, S.Y., Yun, D.J. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
Structure and expression of the Arabidopsis thaliana homeobox gene Athb-12. Lee, Y.H., Oh, H.S., Cheon, C.I., Hwang, I.T., Kim, Y.J., Chun, J.Y. Biochem. Biophys. Res. Commun. (2001) [Pubmed]

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