High impact information on FCA

• The FCA/FY interaction is also required for the downregulation of the floral repressor FLC [1].
• The nuclear RNA binding protein, FCA, promotes Arabidopsis reproductive development [1].
• The introduction of FCA intronless transgenes resulted in increased FCA protein levels and accelerated flowering, but no role in flowering was found for products of the shorter transcripts [2].
• The phenotypes of the 3' end formation esp mutants include impaired termination of the transgene transcripts, early flowering, and enhanced silencing of the FCA-beta mRNA [3].
• These pathways are represented by the genes CO, FCA, and GA1, which act in the long-day, autonomous, and gibberellin pathways, respectively [4].

Biological context of FCA

• Here we show that FCA, an RNA-binding protein involved in flowering, binds ABA with high affinity in an interaction that is stereospecific and follows receptor kinetics [5].
• The inclusion of FCA genomic sequence containing the alternatively processed intron 3 restricted the expression of the transgene predominantly to shoot and root apices and young flower buds [2].
• Overexpression of AGL28 caused precocious flowering via the upregulation of the expression of FCA and LUMINIDEPENDENS (LD), both floral promoters within the autonomous pathway [6].
• We report here its demonstration in a plant genome by reconstructing the physical map of a 1.9 Mbp region around the FCA locus of Arabidopsis thaliana [7].
• Alternative splicing and expression analysis of OsFCA (FCA in Oryza sativa L.), a gene homologous to FCA in Arabidopsis [8].

Associations of FCA with chemical compounds

• Our results indicate that FCA is an ABA receptor involved in RNA metabolism and in controlling flowering time [5].
• The RNA-binding protein FCA is an abscisic acid receptor [5].
• From an analysis of a collection of cDNA and genomic clones, we identified a superfamily of 23 genes encoding all 14 of the Arabidopsis proteasome subunits, designated PAA-PAG and PBA-PBG for Proteasome Alpha and Beta subunits A-G, respectively [9].

Regulatory relationships of FCA

• FCA interacts with the 3'-end RNA-processing factor FY to autoregulate its own expression post-transcriptionally and to control FLC [10].

Other interactions of FCA

• The FCA/FY interaction is also required for the regulation of FLC expression, a major floral repressor in Arabidopsis [11].

Analytical, diagnostic and therapeutic context of FCA

• The fluorescence quantitative PCR analysis showed that the mRNA of OsFCA-1 is the most abundant in the four splicing variants of rice FCA, and its expression level is much higher in differentiating calli than in calli [8].

References