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Gene Review

Taldo1  -  transaldolase 1

Rattus norvegicus

Synonyms: Transaldolase
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Disease relevance of Taldo1

  • The demonstration of increased transaldolase activity in hepatomas, irrespective of the degree of tumor malignancy, differentiation, or growth rate, suggests that the reprogramming of gene expression in malignant transformation is linked with an increase in the expression of this pentose phosphate pathway enzyme.. [1].

High impact information on Taldo1


Anatomical context of Taldo1


Associations of Taldo1 with chemical compounds

  • The transaldolase exchange reaction between fructose 6-phosphate and glyceraldehyde 3-phosphate is very active in these cells [6].
  • Despite these changes, the activities of transaldolase (3.4 +/- 0.3 mumol/min per g), transketolase (7.8 +/- 0.2 mumol/min per g) and ribulose-5-P 3-epimerase (7.5 +/- 0.4 mumol/min per g) were not increased in meal-fed animals above those observed in starved animals (3.4 +/- 0.2, 7.1 +/- 0.3 and 8.6 +/- 0.4 mumol/min per g respectively) [7].
  • The activity of transaldolase in the pentose phosphate pathway was also measured [8].
  • Moreover, activity of glucose-6-phosphate dehydrogenase and expression of transaldolase, enzymes controlling key steps in the oxidative and nonoxidative PPP, respectively, were not different between control and hypertrophied hearts [9].


  1. Behavior of transaldolase (EC and transketolase (EC Activities in normal, neoplastic, differentiating, and regenerating liver. Heinrich, P.C., Morris, H.P., Weber, G. Cancer Res. (1976) [Pubmed]
  2. 13C NMR studies of gluconeogenesis in rat liver cells: utilization of labeled glycerol by cells from euthyroid and hyperthyroid rats. Cohen, S.M., Ogawa, S., Shulman, R.G. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  3. The use of tritiated water to measure absolute rates of hepatic glycogen synthesis. Postle, A.D., Bloxham, D.P. Biochem. J. (1980) [Pubmed]
  4. Exchange reactions catalyzed by group-transferring enzymes oppose the quantitation and the unravelling of the identify of the pentose pathway. Flanigan, I., Collins, J.G., Arora, K.K., MacLeod, J.K., Williams, J.F. Eur. J. Biochem. (1993) [Pubmed]
  5. Pathways of carbohydrate metabolism in peripheral nervous tissue. I. The contribution of alternative routes of glucose utilization in peripheral nerve and brain. Hothersall, J.S., Baquer, N.Z., McLean, P. Enzyme (1982) [Pubmed]
  6. Quantitative measurement of the L-type pentose phosphate cycle with [2-14C]glucose and [5-14C]glucose in isolated hepatocytes. Longenecker, J.P., Williams, J.F. Biochem. J. (1980) [Pubmed]
  7. The content of pentose-cycle intermediates in liver in starved, fed ad libitum and meal-fed rats. Casazza, J.P., Veech, R.L. Biochem. J. (1986) [Pubmed]
  8. Effect of tumor necrosis factor on enzymes of gluconeogenesis in the rat. Yasmineh, W.G., Theologides, A. Proc. Soc. Exp. Biol. Med. (1992) [Pubmed]
  9. Accelerated rates of glycolysis in the hypertrophied heart: are they a methodological artifact? Leong, H.S., Grist, M., Parsons, H., Wambolt, R.B., Lopaschuk, G.D., Brownsey, R., Allard, M.F. Am. J. Physiol. Endocrinol. Metab. (2002) [Pubmed]
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