Disease relevance of Sept9

• Bacterial adherence using E. coli isolated from cecum was compared after coating microtiter plates with SLP or BBM isolated from control and after surgical manipulation [1].
• RLP was extremely inferior to SLP and casein for body weight gain of rats, but that of rats fed with RLP+Met diet was almost equal to that of casein and SLP groups [2].

High impact information on Sept9

• Kinetic analysis of SLP phosphorylation and studies with serine/threonine kinase and phosphatase inhibitors suggest that SLPs are no larger than 70 000 kilodaltons, and that serine/threonine phosphorylation follows tyrosine phosphorylation to substantially retard gel electrophoretic mobility [3].
• 3. This heterogeneous activity is not unique to sympathetic neurons, for inactivating (4), non-inactivating (4), SLP (4) and SHP (3 patches) gating modes were also observed in cell-attached patch recordings (n = 4) of single N-type Ca2+ channels in differentiated phaeochromocytoma (PC12) cells [4].
• Adherence of bacteria onto the glycoconjugates of the brush border membrane (BBM) and surfactant coat (SLP) of the mucosal cells is the first step in the translocation of luminal bacteria [1].
• Nicorandil (10(-3) M) significantly blocked SLP (10(-5) M)- or QIN (10(-3) M)-induced increases in DA levels in the striatum [5].
• The serum cholesterol level in rats fed with SLP and SLP+Met diets was significantly lower as compared with that of the casein-fed rats [2].

Biological context of Sept9

• These results suggest that the hypocholesterolemic action of SLP may in part have been due to the inhibition of intestinal absorption of both cholesterol and bile acids [2].

Associations of Sept9 with chemical compounds

• Radish and spinach leaf protein isolates (RLP and SLP, respectively) were prepared from chilled aqueous 0.2% sodium hydroxide extract of their leaves [2].
• The RLP and SLP, and those supplemented with methionine (RLP+Met and SLP+Met, respectively) to become equal to casein in methionine content, were compared with casein for their effects on serum cholesterol level in rats fed with a cholesterol-enriched diet for 14 days [2].

References