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Slco1c1  -  solute carrier organic anion transporter...

Rattus norvegicus

Synonyms: BBB-specific anion transporter type 1, Blood-brain barrier-specific anion transporter 1, Bsat1, Oatp14, Oatp1c1, ...
 
 
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High impact information on Slco1c1

 

Associations of Slco1c1 with chemical compounds

  • Therefore, it may be speculated that Oatp14 plays a role in maintaining the concentration of T4 and, ultimately, T3 in the brain by transporting T4 from the circulating blood to the brain [1].
  • When expressed in human embryonic kidney 293 cells, Oatp14 transports thyroxine (T4; prothyroid hormone) (Km = 0.18 mum), as well as amphipathic organic anions such as 17beta estradiol-d-17beta-glucuronide (Km = 10 mum), cerivastatin (Km = 1.3 mum), and troglitazone sulfate (Km = 0.76 mum) [1].
 

Other interactions of Slco1c1

  • Changes in the transcripts of genes encoding 2 transporters [blood-brain specific anion transporter (Slco1c1) and sodium-dependent inorganic phosphate cotransporter (Slc17a7)] were confirmed by real-time RT-PCR [2].

References

  1. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. Sugiyama, D., Kusuhara, H., Taniguchi, H., Ishikawa, S., Nozaki, Y., Aburatani, H., Sugiyama, Y. J. Biol. Chem. (2003) [Pubmed]
  2. Identification of Rat Hippocampal mRNAs Altered by the Mitochondrial Toxicant, 3-NPA. Przybyla-Zawislak, B.D., Thorn, B.T., Ali, S.F., Dennis, R.A., Amato, A., Virmani, A., Binienda, Z.K. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
 
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