The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Slco1c1  -  solute carrier organic anion transporter...

Rattus norvegicus

Synonyms: BBB-specific anion transporter type 1, Blood-brain barrier-specific anion transporter 1, Bsat1, Oatp14, Oatp1c1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Slco1c1


Associations of Slco1c1 with chemical compounds

  • Therefore, it may be speculated that Oatp14 plays a role in maintaining the concentration of T4 and, ultimately, T3 in the brain by transporting T4 from the circulating blood to the brain [1].
  • When expressed in human embryonic kidney 293 cells, Oatp14 transports thyroxine (T4; prothyroid hormone) (Km = 0.18 mum), as well as amphipathic organic anions such as 17beta estradiol-d-17beta-glucuronide (Km = 10 mum), cerivastatin (Km = 1.3 mum), and troglitazone sulfate (Km = 0.76 mum) [1].

Other interactions of Slco1c1

  • Changes in the transcripts of genes encoding 2 transporters [blood-brain specific anion transporter (Slco1c1) and sodium-dependent inorganic phosphate cotransporter (Slc17a7)] were confirmed by real-time RT-PCR [2].


  1. Functional characterization of rat brain-specific organic anion transporter (Oatp14) at the blood-brain barrier: high affinity transporter for thyroxine. Sugiyama, D., Kusuhara, H., Taniguchi, H., Ishikawa, S., Nozaki, Y., Aburatani, H., Sugiyama, Y. J. Biol. Chem. (2003) [Pubmed]
  2. Identification of Rat Hippocampal mRNAs Altered by the Mitochondrial Toxicant, 3-NPA. Przybyla-Zawislak, B.D., Thorn, B.T., Ali, S.F., Dennis, R.A., Amato, A., Virmani, A., Binienda, Z.K. Ann. N. Y. Acad. Sci. (2005) [Pubmed]
WikiGenes - Universities