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Gene Review

SLCO1C1  -  solute carrier organic anion transporter...

Homo sapiens

Synonyms: OAT-RP-5, OATP-14, OATP-F, OATP1, OATP14, ...
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Disease relevance of SLCO1C1

  • We characterized the interaction of MTX with human organic-anion transporting polypeptide transporter (OATP) 1A2, which is expressed in tissues important for MTX disposition and toxicity, such as the intestine, kidney, liver, and endothelial cells of the blood-brain barrier [1].

High impact information on SLCO1C1


Biological context of SLCO1C1

  • Northern and Western blot analyses confirmed a previous finding that the gene expression of Oatp1, which is localized at the apical plasma membrane of the kidney, was much higher in the kidneys of male rats [4].
  • Overall, a gender difference in urinary excretion is commonly observed for several organic anions, including Oatp1 substrates and inhibitors, and Oatp1 and/or transporters that have a similar substrate specificity to Oatp1 could be involved in such a phenomenon involving its substrates [4].

Anatomical context of SLCO1C1

  • Organic anion transporting polypeptide (OATP) superfamily member 2B1 (OATP2B1) mediates the uptake of steroid hormone precursors and selected drugs in the placenta, liver, mammary gland, brain, and intestine [5].
  • A weak cytostatic effect of BANB-1, BANB-2 and BANB-3 was detected even in CHO cells stably transfected with rat bile acid transporters (Ntcp and Oatp1/1a1) [6].
  • Keywords: Fluoroquinolone; transporter; OATP; absorption; intestine; levofloxacin; Caco-2 cell [7].
  • It has already been demonstrated that pitavastatin, a novel potent HMG-coenzyme A reductase inhibitor, is taken up into human hepatocytes mainly by organic anion transporting polypeptide (OATP) 1B1 [8].
  • However, for human OATPs additional regional differences in expression were found with OATP1A2 and OATP1C1 being expressed only in the pars plana of human ciliary body epithelium [9].

Associations of SLCO1C1 with chemical compounds


Other interactions of SLCO1C1


  1. Interaction of methotrexate with organic-anion transporting polypeptide 1A2 and its genetic variants. Badagnani, I., Castro, R.A., Taylor, T.R., Brett, C.M., Huang, C.C., Stryke, D., Kawamoto, M., Johns, S.J., Ferrin, T.E., Carlson, E.J., Burchard, E.G., Giacomini, K.M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  2. Drug and bile acid transporters in rosuvastatin hepatic uptake: function, expression, and pharmacogenetics. Ho, R.H., Tirona, R.G., Leake, B.F., Glaeser, H., Lee, W., Lemke, C.J., Wang, Y., Kim, R.B. Gastroenterology (2006) [Pubmed]
  3. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Pizzagalli, F., Hagenbuch, B., Stieger, B., Klenk, U., Folkers, G., Meier, P.J. Mol. Endocrinol. (2002) [Pubmed]
  4. Gender difference in the urinary excretion of organic anions in rats. Kato, Y., Kuge, K., Kusuhara, H., Meier, P.J., Sugiyama, Y. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  5. Functional analysis of the extracellular cysteine residues in the human organic anion transporting polypeptide, OATP2B1. Hänggi, E., Grundschober, A.F., Leuthold, S., Meier, P.J., St-Pierre, M.V. Mol. Pharmacol. (2006) [Pubmed]
  6. Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases. Vallejo, M., Castro, M.A., Medarde, M., Macias, R.I., Romero, M.R., El-Mir, M.Y., Monte, M.J., Briz, O., Serrano, M.A., Marin, J.J. Biochem. Pharmacol. (2007) [Pubmed]
  7. Identification of influx transporter for the quinolone antibacterial agent levofloxacin. Maeda, T., Takahashi, K., Ohtsu, N., Oguma, T., Ohnishi, T., Atsumi, R., Tamai, I. Mol. Pharm. (2007) [Pubmed]
  8. Drug-drug interaction between pitavastatin and various drugs via OATP1B1. Hirano, M., Maeda, K., Shitara, Y., Sugiyama, Y. Drug Metab. Dispos. (2006) [Pubmed]
  9. Localization of organic anion transporting polypeptides in the rat and human ciliary body epithelium. Gao, B., Huber, R.D., Wenzel, A., Vavricka, S.R., Ismair, M.G., Remé, C., Meier, P.J. Exp. Eye Res. (2005) [Pubmed]
  10. Predominant contribution of OATP1B3 to the hepatic uptake of telmisartan, an angiotensin II receptor antagonist, in humans. Ishiguro, N., Maeda, K., Kishimoto, W., Saito, A., Harada, A., Ebner, T., Roth, W., Igarashi, T., Sugiyama, Y. Drug Metab. Dispos. (2006) [Pubmed]
  11. Thyroid hormone transporters in health and disease. Jansen, J., Friesema, E.C., Milici, C., Visser, T.J. Thyroid (2005) [Pubmed]
  12. The complexity of intestinal absorption and exsorption of digoxin in rats. Yao, H.M., Chiou, W.L. International journal of pharmaceutics. (2006) [Pubmed]
  13. Pharmacokinetics of fexofenadine enantiomers in healthy subjects. Miura, M., Uno, T., Tateishi, T., Suzuki, T. Chirality (2007) [Pubmed]
  14. The organic anion transport polypeptide 1d1 (Oatp1d1) mediates hepatocellular uptake of phalloidin and microcystin into skate liver. Meier-Abt, F., Hammann-Hänni, A., Stieger, B., Ballatori, N., Boyer, J.L. Toxicol. Appl. Pharmacol. (2007) [Pubmed]
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