High impact information on Prss12

• Expression of a serine protease (motopsin PRSS12) mRNA in the mouse brain: in situ hybridization histochemical study [1].
• The above findings strongly suggest that neurons in almost all motor nuclei, particularly in the brainstem and spinal cord, express motopsin mRNA, and that motopsin seems to have a close relation to the functional role of efferent neurons [1].
• In an attempt to find novel brain-specific serine proteases (BSSPs), motopsin (PRSS-12) was cloned from a mouse brain cDNA library by polymerase chain reaction (PCR) [1].
• At this developmental stage, in situ hybridization histochemistry showed that motopsin mRNA was specifically expressed in the following regions: cerebral cortical layers II/III, V and VIb, endopiriform cortex and the limbic system, particularly in the CA1 region of the hippocampal formation [1].
• In addition, in the brainstem, the oculomotor nucleus, trochlear nucleus, mecencephalic and motor nuclei of trigeminal nerve (N), abducens nucleus, facial nucleus, nucleus of the raphe pontis, dorsoral motor nucleus of vagal N, hypoglossal nucleus and ambiguus nucleus showed motopsin mRNA expression [1].

Biological context of Prss12

• We concluded that a novel brain serine protease, BSSP-3, is a new member of kringle and SRCR superfamilies [2].

Anatomical context of Prss12

• The expression of a motoneuron-specific serine protease, motopsin (PRSS12), after facial nerve axotomy in mice [3].
• Motopsin (PRSS12) is a mosaic serine protease that is preferentially expressed in motor neurons [3].

Other interactions of Prss12

• As found in known serine proteases, BSSP-3 enzyme domain contained a catalytic triad which consists of AA residues essential for the enzyme activity [2].

Analytical, diagnostic and therapeutic context of Prss12

• Northern blot analysis demonstrated that the postnatal 10-day mouse brain contained the most amount of motopsin mRNA [1].

References