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Gene Review

CHA1  -  L-serine/L-threonine ammonia-lyase CHA1

Saccharomyces cerevisiae S288c

Synonyms: Catabolic L-serine/threonine dehydratase, YCL064C, YCL64C
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High impact information on CHA1

  • We found that NHP6A/B proteins are also required for full induction of the yeast CHA1 gene [1].
  • In addition, deletion of the gene-specific activator Cha4p did not affect derepression of CHA1 in cells depleted for Swh3p [2].
  • Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC [2].
  • The yeast CHA1 promoter is activated in the presence of serine or threonine [3].
  • Consistent with this interpretation, artificially recruited TBP was unable to perturb nucleosome positioning via a nucleosomal binding site, in contrast to a true activator such as GAL4, or to perturb the TATA-containing nucleosome at the CHA1 promoter [4].

Biological context of CHA1


Associations of CHA1 with chemical compounds


Regulatory relationships of CHA1

  • Thus, the H3 amino terminus is required to prevent Cha4p from activating CHA1 in the absence of inducer [3].

Other interactions of CHA1


Analytical, diagnostic and therapeutic context of CHA1

  • Furthermore, derepression in the absence of the H3 amino terminus requires the primary activator of this promoter, Cha4p, which we show by chromatin immunoprecipitation to be constitutively bound to the CHA1 promoter in WT yeast [3].


  1. Chromatin-mediated transcriptional regulation by the yeast architectural factors NHP6A and NHP6B. Moreira, J.M., Holmberg, S. EMBO J. (2000) [Pubmed]
  2. Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC. Moreira, J.M., Holmberg, S. EMBO J. (1999) [Pubmed]
  3. Global and specific transcriptional repression by the histone H3 amino terminus in yeast. Sabet, N., Tong, F., Madigan, J.P., Volo, S., Smith, M.M., Morse, R.H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Artificially recruited TATA-binding protein fails to remodel chromatin and does not activate three promoters that require chromatin remodeling. Ryan, M.P., Stafford, G.A., Yu, L., Morse, R.H. Mol. Cell. Biol. (2000) [Pubmed]
  5. Locus-specific suppression of ilv1 in Saccharomyces cerevisiae by deregulation of CHA1 transcription. Pedersen, J.O., Rodríguez, M.A., Praetorius-Ibba, M., Nilsson-Tillgren, T., Calderón, I.L., Holmberg, S. Mol. Gen. Genet. (1997) [Pubmed]
  6. Cha4p of Saccharomyces cerevisiae activates transcription via serine/threonine response elements. Holmberg, S., Schjerling, P. Genetics (1996) [Pubmed]
  7. A regulatory element in the CHA1 promoter which confers inducibility by serine and threonine on Saccharomyces cerevisiae genes. Bornaes, C., Ignjatovic, M.W., Schjerling, P., Kielland-Brandt, M.C., Holmberg, S. Mol. Cell. Biol. (1993) [Pubmed]
  8. Serine and threonine catabolism in Saccharomyces cerevisiae: the CHA1 polypeptide is homologous with other serine and threonine dehydratases. Bornaes, C., Petersen, J.G., Holmberg, S. Genetics (1992) [Pubmed]
  9. Isolation and sequencing of a gene, C-ADE1, and its use for a host-vector system in Candida maltosa with two genetic markers. Kawai, S., Hikiji, T., Murao, S., Takagi, M., Yano, K. Agric. Biol. Chem. (1991) [Pubmed]
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