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Gene Review

ILV5  -  ketol-acid reductoisomerase

Saccharomyces cerevisiae S288c

Synonyms: Acetohydroxy-acid reductoisomerase, Alpha-keto-beta-hydroxylacyl reductoisomerase, Ketol-acid reductoisomerase, mitochondrial, L9638.7, YLR355C
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Disease relevance of ILV5

  • Finally, the wild-type Escherichia coli ortholog of Ilv5p behaves like a(+)D(-) mutants when expressed and targeted to mitochondria in ilv5Delta yeast cells, suggesting that yeast Ilv5p acquired its mtDNA function after the endosymbiotic event [1].

High impact information on ILV5

  • An overview of the layered controls of the extended leucine pathway is provided that includes a description of the newly recognized roles of Ilv5p and Bat1p in maintaining mitochondrial integrity [2].
  • The most severe instability of rho+ mtDNA is observed in cells with null alleles of both ABF2 and ILV5 [3].
  • The instability of rho+ mtDNA in delta ilv5 cells is not simply a consequence of a block in branched-chain amino acid biosynthesis, since mtDNA is stable in cells with a null allele of the ILV2 gene, which encodes another enzyme of that pathway [3].
  • The nucleotide sequence of the yeast ILV5 gene, which codes for the branched-chain amino acid biosynthesis enzyme acetohydroxyacid reductoisomerase, has been determined [4].
  • Genes ilvC and ilv5 code for the enzyme acetohydroxy acid isomeroreductase (isomeroreductase), the second enzyme in the parallel pathways for the biosynthesis of isoleucine and valine [5].

Biological context of ILV5

  • The STE11 gene, which had previously been mapped to chromosome XII (Chaleff and Tatchell, 1985), was found to be tightly linked to ILV5 [6].
  • Tandem integration of multiple ILV5 copies and elevated transcription in polyploid yeast [7].
  • Linear DNA containing the cloned ILV5 gene was introduced into lager yeast along with an unlinked circular bifunctional plasmid containing a dominant resistance marker [7].
  • Effects of ploidy, growth conditions and the mitochondrial nucleoid-associated protein Ilv5p on the rate of mutation of mitochondrial DNA in Saccharomyces cerevisiae [8].

Associations of ILV5 with chemical compounds


Other interactions of ILV5

  • The CHL3 gene is placed on the right arm of chromosome XII, between the ILV5 (33.3 cM) and URA4 (21.8 cM) loci [10].
  • Thus, the ILV1 gene is under general amino acid control, as is the case for both the ILV5 and the transaminase gene [11].

Analytical, diagnostic and therapeutic context of ILV5


  1. Mutational bisection of the mitochondrial DNA stability and amino acid biosynthetic functions of ilv5p of budding yeast. Bateman, J.M., Perlman, P.S., Butow, R.A. Genetics (2002) [Pubmed]
  2. Leucine biosynthesis in fungi: entering metabolism through the back door. Kohlhaw, G.B. Microbiol. Mol. Biol. Rev. (2003) [Pubmed]
  3. An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. Zelenaya-Troitskaya, O., Perlman, P.S., Butow, R.A. EMBO J. (1995) [Pubmed]
  4. The ILV5 gene of Saccharomyces cerevisiae is highly expressed. Petersen, J.G., Holmberg, S. Nucleic Acids Res. (1986) [Pubmed]
  5. The product of the Rhizobium meliloti ilvC gene is required for isoleucine and valine synthesis and nodulation of alfalfa. Aguilar, O.M., Grasso, D.H. J. Bacteriol. (1991) [Pubmed]
  6. Mapping of the Saccharomyces cerevisiae CDC3, CDC25, and CDC42 genes to chromosome XII by chromosome blotting and tetrad analysis. Johnson, D.I., Jacobs, C.W., Pringle, J.R., Robinson, L.C., Carle, G.F., Olson, M.V. Yeast (1987) [Pubmed]
  7. Tandem integration of multiple ILV5 copies and elevated transcription in polyploid yeast. Mithieux, S.M., Weiss, A.S. Yeast (1995) [Pubmed]
  8. Effects of ploidy, growth conditions and the mitochondrial nucleoid-associated protein Ilv5p on the rate of mutation of mitochondrial DNA in Saccharomyces cerevisiae. Sia, R.A., Urbonas, B.L., Sia, E.A. Curr. Genet. (2003) [Pubmed]
  9. Towards diacetyl-less brewers' yeast. Influence of ilv2 and ilv5 mutations. Gjermansen, C., Nilsson-Tillgren, T., Petersen, J.G., Kielland-Brandt, M.C., Sigsgaard, P., Holmberg, S. J. Basic Microbiol. (1988) [Pubmed]
  10. Identification and genetic mapping of CHL genes controlling mitotic chromosome transmission in yeast. Kouprina, N., Tsouladze, A., Koryabin, M., Hieter, P., Spencer, F., Larionov, V. Yeast (1993) [Pubmed]
  11. Regulation of isoleucine-valine biosynthesis in Saccharomyces cerevisiae. Holmberg, S., Petersen, J.G. Curr. Genet. (1988) [Pubmed]
  12. Isolation, characterization and sequence analysis of a full-length cDNA clone encoding acetohydroxy acid reductoisomerase from spinach chloroplasts. Dumas, R., Lebrun, M., Douce, R. Biochem. J. (1991) [Pubmed]
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