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Gene Review

KCS1  -  inositol polyphosphate kinase KCS1

Saccharomyces cerevisiae S288c

Synonyms: Inositol hexakisphosphate kinase 1, InsP6 kinase 1, InsP6 kinase KCS1, PKC1 suppressor protein 1, PZF1050, ...
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High impact information on KCS1

  • Overexpression of KCS1, but not of the other genes, suppressed PHO5 expression in the wild-type strain under low phosphate conditions [1].
  • Here we report the regulation of telomere length by production of a diphosphorylinositol tetrakisphosphate, PP-IP4, synthesized by the KCS1 gene product [2].
  • Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae [1].
  • In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis [3].
  • Biogenesis of the yeast vacuole also required another functional domain in Kcs1p, which contains two leucine heptad repeats [3].

Biological context of KCS1

  • This metabolic block was partially bypassed, and the phenotype was partially rescued, when Kcs1p was overexpressed in the arg82Delta cells [3].
  • The kinase activity of Kcs1p was also found to sustain cell growth and integrity of the cell wall and to promote adaptive responses to salt stress [3].
  • At1g01120 KCS (KCS1) and At2g26640 KCS had broad substrate specificities when assayed with saturated and mono-unsaturated C16 to C24 acyl-CoAs while At4g34510 KCS was specific for saturated fatty acyl-CoA substrates [4].

Associations of KCS1 with chemical compounds

  • KCS1 was cloned and found to encode a novel protein with homology to the basic leucine zipper family of transcription factors [5].
  • Arg82p and Kcs1p are required for activation of NCR-regulated genes in response to nitrogen availability, mainly through Nil1p, and for repression of PHO genes by phosphate [6].

Other interactions of KCS1

  • Eight of these suppressors for into two complementation groups, designated KCS1 and KCS2 [5].

Analytical, diagnostic and therapeutic context of KCS1


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