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Gene Review:

KCS1 - inositol polyphosphate kinase KCS1

Saccharomyces cerevisiae S288c

Synonyms: Inositol hexakisphosphate kinase 1, InsP6 kinase 1, InsP6 kinase KCS1, PKC1 suppressor protein 1, PZF1050, ...

Dubois, E. et al., Auesukaree, C. et al., El Alami, M. et al., Blacklock, B.J. et al., Huang, K.N. et al., et al.

York, Armbruster, Greenwell, Petes, York,

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High impact information on KCS1

Overexpression of KCS1, but not of the other genes, suppressed PHO5 expression in the wild-type strain under low phosphate conditions [1].
Here we report the regulation of telomere length by production of a diphosphorylinositol tetrakisphosphate, PP-IP4, synthesized by the KCS1 gene product [2].
Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae [1].
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis [3].
Biogenesis of the yeast vacuole also required another functional domain in Kcs1p, which contains two leucine heptad repeats [3].

Biological context of KCS1

This metabolic block was partially bypassed, and the phenotype was partially rescued, when Kcs1p was overexpressed in the arg82Delta cells [3].
The kinase activity of Kcs1p was also found to sustain cell growth and integrity of the cell wall and to promote adaptive responses to salt stress [3].
At1g01120 KCS (KCS1) and At2g26640 KCS had broad substrate specificities when assayed with saturated and mono-unsaturated C16 to C24 acyl-CoAs while At4g34510 KCS was specific for saturated fatty acyl-CoA substrates [4].

Associations of KCS1 with chemical compounds

KCS1 was cloned and found to encode a novel protein with homology to the basic leucine zipper family of transcription factors [5].
Arg82p and Kcs1p are required for activation of NCR-regulated genes in response to nitrogen availability, mainly through Nil1p, and for repression of PHO genes by phosphate [6].

Other interactions of KCS1

Eight of these suppressors for into two complementation groups, designated KCS1 and KCS2 [5].

Analytical, diagnostic and therapeutic context of KCS1

To define physiologically relevant targets of the catalytic products of Arg82p and Kcs1p, we used DNA microarray technology [6].

References

Plc1p, Arg82p, and Kcs1p, enzymes involved in inositol pyrophosphate synthesis, are essential for phosphate regulation and polyphosphate accumulation in Saccharomyces cerevisiae. Auesukaree, C., Tochio, H., Shirakawa, M., Kaneko, Y., Harashima, S. J. Biol. Chem. (2005) [Pubmed]
Inositol diphosphate signaling regulates telomere length. York, S.J., Armbruster, B.N., Greenwell, P., Petes, T.D., York, J.D. J. Biol. Chem. (2005) [Pubmed]
In Saccharomyces cerevisiae, the inositol polyphosphate kinase activity of Kcs1p is required for resistance to salt stress, cell wall integrity, and vacuolar morphogenesis. Dubois, E., Scherens, B., Vierendeels, F., Ho, M.M., Messenguy, F., Shears, S.B. J. Biol. Chem. (2002) [Pubmed]
Substrate specificity of Arabidopsis 3-ketoacyl-CoA synthases. Blacklock, B.J., Jaworski, J.G. Biochem. Biophys. Res. Commun. (2006) [Pubmed]
Suppressors of a Saccharomyces cerevisiae pkc1 mutation identify alleles of the phosphatase gene PTC1 and of a novel gene encoding a putative basic leucine zipper protein. Huang, K.N., Symington, L.S. Genetics (1995) [Pubmed]
Arg82p is a bifunctional protein whose inositol polyphosphate kinase activity is essential for nitrogen and PHO gene expression but not for Mcm1p chaperoning in yeast. El Alami, M., Messenguy, F., Scherens, B., Dubois, E. Mol. Microbiol. (2003) [Pubmed]

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