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Gene Review

CDC1  -  putative lipid phosphatase CDC1

Saccharomyces cerevisiae S288c

Synonyms: Cell division control protein 1, DSC1, DSR1, ESP2, YD9395.16, ...
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Disease relevance of CDC1


High impact information on CDC1

  • A cis-acting hexamer element ACGCGT (an MluI restriction site) is responsible for coordinating transcriptional regulation of these genes at the G1/S phase boundary and we have identified a binding activity, DSC1, that recognizes these sequences in a cell-cycle-dependent manner [2].
  • In Schizosaccharomyces pombe, this regulation is mediated by MCB elements that serve as binding sites for the MBF/DSC-1 complex [3].
  • Mutations in CDC1 severely depolarize the actin cytoskeleton, and these mutations prevent late Golgi elements from being retained in the bud [4].
  • In wild-type yeast, the disruption of BRY1 has no apparent phenotype, but under conditions where the activities of SBF and DSC1/MBF are reduced, BRY1 becomes essential [5].
  • The transcription factors SBF and DSC1/MBF bind SCB and MCB promoter elements, respectively, and are essential for the cell cycle progression of Saccharomyces cerevisiae through the control of G1 cyclin gene expression [5].

Biological context of CDC1


Anatomical context of CDC1


Other interactions of CDC1

  • An alternative model is that the p34CDC28/G1 cyclin complexes have several targets post-START, one being DSC1 and the others being as yet unidentified components of the pathways leading to CDC4 function, spindle pole body duplication and bud emergence [10].
  • Previous studies have demonstrated a direct interaction between Pol3 and Cdc1, the B-subunit of the complex [11].


  1. Alphaherpesviruses possess a gene homologous to the protein kinase gene family of eukaryotes and retroviruses. McGeoch, D.J., Davison, A.J. Nucleic Acids Res. (1986) [Pubmed]
  2. Control of DNA synthesis genes in fission yeast by the cell-cycle gene cdc10+. Lowndes, N.F., McInerny, C.J., Johnson, A.L., Fantes, P.A., Johnston, L.H. Nature (1992) [Pubmed]
  3. pct1+, which encodes a new DNA-binding partner of p85cdc10, is required for meiosis in the fission yeast Schizosaccharomyces pombe. Zhu, Y., Takeda, T., Nasmyth, K., Jones, N. Genes Dev. (1994) [Pubmed]
  4. A role for actin, Cdc1p, and Myo2p in the inheritance of late Golgi elements in Saccharomyces cerevisiae. Rossanese, O.W., Reinke, C.A., Bevis, B.J., Hammond, A.T., Sears, I.B., O'Connor, J., Glick, B.S. J. Cell Biol. (2001) [Pubmed]
  5. A yeast transcription factor bypassing the requirement for SBF and DSC1/MBF in budding yeast has homology to bacterial signal transduction proteins. Morgan, B.A., Bouquin, N., Merrill, G.F., Johnston, L.H. EMBO J. (1995) [Pubmed]
  6. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Supek, F., Supekova, L., Nelson, H., Nelson, N. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  7. Mutations in the Saccharomyces cerevisiae CDC1 gene affect double-strand-break-induced intrachromosomal recombination. Halbrook, J., Hoekstra, M.F. Mol. Cell. Biol. (1994) [Pubmed]
  8. The frost gene of Neurospora crassa is a homolog of yeast cdc1 and affects hyphal branching via manganese homeostasis. Sone, T., Griffiths, A.J. Fungal Genet. Biol. (1999) [Pubmed]
  9. Cdc1 and the vacuole coordinately regulate Mn2+ homeostasis in the yeast Saccharomyces cerevisiae. Paidhungat, M., Garrett, S. Genetics (1998) [Pubmed]
  10. Starting to cycle: G1 controls regulating cell division in budding yeast. Sherlock, G., Rosamond, J. J. Gen. Microbiol. (1993) [Pubmed]
  11. The C-terminal zinc finger of the catalytic subunit of DNA polymerase delta is responsible for direct interaction with the B-subunit. Sanchez Garcia, J., Ciufo, L.F., Yang, X., Kearsey, S.E., MacNeill, S.A. Nucleic Acids Res. (2004) [Pubmed]
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