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Gene Review

TAT1  -  amino acid transporter TAT1

Saccharomyces cerevisiae S288c

Synonyms: TAP1, Tyrosine and tryptophan amino acid transporter 1, VAP1, Valine/tyrosine/tryptophan amino-acid permease 1, YBR069C, ...
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Disease relevance of TAT1

  • The second system studied consisted of the (+18)-(+44) fragment of the trans-activation response element of human immunodeficiency virus type 1 (TAR RNA HIV-1) and a 9-amino-acid peptide of the trans-activator of transcription protein (Tat HIV-1) Tat(49-57)-NH(2) (named Tat1: Arg(49)-Lys-Lys-Arg(52)-Arg-Gln-Arg-Arg- Arg(57)-NH(2)) [1].

High impact information on TAT1

  • The HPG1 mutation or the bul1Delta bul2Delta double mutation caused a marked increase in the steady-state level of Tat2 but not of Tat1, although both permeases were degraded at high pressure in an Rsp5-dependent manner [2].
  • Moreover, Tat1 was associated with lipid rafts, whereas Tat2 localized in bulk lipids [2].
  • Two FK506 resistance-conferring genes in Saccharomyces cerevisiae, TAT1 and TAT2, encode amino acid permeases mediating tyrosine and tryptophan uptake [3].
  • Antitubulin TAT1 antibody revealed a microtubular cytoskeleton consisting of cytoplasmic and spindle microtubules [4].
  • Sequencing of the inserts revealed the presence of the HIP1 gene and also the presence of the TAT1 gene [5].

Biological context of TAT1


Anatomical context of TAT1


Associations of TAT1 with chemical compounds


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