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Gene Review

TAT2  -  aromatic amino acid transmembrane...

Saccharomyces cerevisiae S288c

Synonyms: LTG3, SAB2, SCM2, TAP2, Tryptophan amino acid transporter, ...
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Disease relevance of TAT2


High impact information on TAT2

  • Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane [2].
  • Furthermore, our results suggest that TAT2 stability and sorting are controlled by the TOR signaling pathway, and regulated inversely to that of GAP1 [3].
  • Upon nutrient deprivation or rapamycin treatment, TAT2 is transported to and degraded in the vacuole [3].
  • The ubiquitination machinery and lysine residues within the NH(2)-terminal 31 amino acids of TAT2 mediate ubiquitination and degradation of the permease [3].
  • The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease [4].

Biological context of TAT2


Anatomical context of TAT2

  • In exponentially growing cells, TAT2 is in the plasma membrane and also accumulates in internal compartments of the secretory pathway [3].

Associations of TAT2 with chemical compounds


Physical interactions of TAT2


Regulatory relationships of TAT2


Other interactions of TAT2


  1. Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants. Bauer, B.E., Rossington, D., Mollapour, M., Mamnun, Y., Kuchler, K., Piper, P.W. Eur. J. Biochem. (2003) [Pubmed]
  2. Ergosterol is required for targeting of tryptophan permease to the yeast plasma membrane. Umebayashi, K., Nakano, A. J. Cell Biol. (2003) [Pubmed]
  3. Starvation induces vacuolar targeting and degradation of the tryptophan permease in yeast. Beck, T., Schmidt, A., Hall, M.N. J. Cell Biol. (1999) [Pubmed]
  4. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. Schmidt, A., Beck, T., Koller, A., Kunz, J., Hall, M.N. EMBO J. (1998) [Pubmed]
  5. Tryptophan permease gene TAT2 confers high-pressure growth in Saccharomyces cerevisiae. Abe, F., Horikoshi, K. Mol. Cell. Biol. (2000) [Pubmed]
  6. SCM2, a tryptophan permease in Saccharomyces cerevisiae, is important for cell growth. Chen, X.H., Xiao, Z., Fitzgerald-Hayes, M. Mol. Gen. Genet. (1994) [Pubmed]
  7. Genetic, biochemical, and transcriptional responses of Saccharomyces cerevisiae to the novel immunomodulator FTY720 largely mimic those of the natural sphingolipid phytosphingosine. Welsch, C.A., Roth, L.W., Goetschy, J.F., Movva, N.R. J. Biol. Chem. (2004) [Pubmed]
  8. Activity of the yeast Tat2p tryptophan permease is sensitive to the anti-tumor agent 4-phenylbutyrate. Liu, M., Brusilow, W.S., Needleman, R. Curr. Genet. (2004) [Pubmed]
  9. Isolation and characterization of Saccharomyces cerevisiae SAB2, a suppressor gene for temperature-sensitive phenotype of ARS-binding factor 1 mutant. Shin, Y.H., Goo, D.M., So, I.S., Rhode, P.R., Campbell, J.L., Kim, J. Biochem. Mol. Biol. Int. (1996) [Pubmed]
  10. Multiple ubiquitin-specific protease genes are involved in degradation of yeast tryptophan permease Tat2 at high pressure. Miura, T., Abe, F. FEMS Microbiol. Lett. (2004) [Pubmed]
  11. Pressure-induced differential regulation of the two tryptophan permeases Tat1 and Tat2 by ubiquitin ligase Rsp5 and its binding proteins, Bul1 and Bul2. Abe, F., Iida, H. Mol. Cell. Biol. (2003) [Pubmed]
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