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Gene Review

HIP1  -  histidine permease

Saccharomyces cerevisiae S288c

Synonyms: G7572, Histidine permease, YGR191W
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Disease relevance of HIP1


High impact information on HIP1


Biological context of HIP1

  • We sequenced a 2.4-kb subfragment of this BamHI-Sau3A fragment containing the HIP1 gene and identified a 1596-bp open reading frame (ORF) [6].
  • The HIP1 gene maps to the right arm of chromosome VII, approx. 11 cM distal to the ADE3 gene [6].
  • Analysis of the deduced amino acid sequences revealed that one (HIP1) of the two HCpro interactors is a novel RING finger protein [7].

Associations of HIP1 with chemical compounds


Other interactions of HIP1

  • In the aligned sequences HIP1 and CAN1, the postulated membrane-spanning alpha-helices often start at corresponding sites, even though the overall sequence similarity of the two proteins is only 30% [10].
  • We report that mutations in the HIP1 and SHM1 genes exhibit synthetic lethality with ade3 deletions [11].
  • This defect in histidine uptake, exhibited by the sln2 mutant in the absence but not in the presence of Ubr1p, was traced to the gene HIP1, which encodes the histidine transporter [12].
  • Sequencing of the inserts revealed the presence of the HIP1 gene and also the presence of the TAT1 gene [8].


  1. Cloning and sequencing of the pheP gene, which encodes the phenylalanine-specific transport system of Escherichia coli. Pi, J., Wookey, P.J., Pittard, A.J. J. Bacteriol. (1991) [Pubmed]
  2. Amino acid permeases require COPII components and the ER resident membrane protein Shr3p for packaging into transport vesicles in vitro. Kuehn, M.J., Schekman, R., Ljungdahl, P.O. J. Cell Biol. (1996) [Pubmed]
  3. Isolation of a gene encoding a chaperonin-like protein by complementation of yeast amino acid transport mutants with human cDNA. Segel, G.B., Boal, T.R., Cardillo, T.S., Murant, F.G., Lichtman, M.A., Sherman, F. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  4. The phosphoinositide phosphatase Sjl2 is recruited to cortical actin patches in the control of vesicle formation and fission during endocytosis. Stefan, C.J., Padilla, S.M., Audhya, A., Emr, S.D. Mol. Cell. Biol. (2005) [Pubmed]
  5. Scd5p and clathrin function are important for cortical actin organization, endocytosis, and localization of sla2p in yeast. Henry, K.R., D'Hondt, K., Chang, J., Newpher, T., Huang, K., Hudson, R.T., Riezman, H., Lemmon, S.K. Mol. Biol. Cell (2002) [Pubmed]
  6. The histidine permease gene (HIP1) of Saccharomyces cerevisiae. Tanaka, J., Fink, G.R. Gene (1985) [Pubmed]
  7. Two potato proteins, including a novel RING finger protein (HIP1), interact with the potyviral multifunctional protein HCpro. Guo, D., Spetz, C., Saarma, M., Valkonen, J.P. Mol. Plant Microbe Interact. (2003) [Pubmed]
  8. TAT1 encodes a low-affinity histidine transporter in Saccharomyces cerevisiae. Bajmoczi, M., Sneve, M., Eide, D.J., Drewes, L.R. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  9. Involvement of histidine permease (Hip1p) in manganese transport in Saccharomyces cerevisiae. Farcasanu, I.C., Mizunuma, M., Hirata, D., Miyakawa, T. Mol. Gen. Genet. (1998) [Pubmed]
  10. Evolutionary relationship and secondary structure predictions in four transport proteins of Saccharomyces cerevisiae. Weber, E., Chevallier, M.R., Jund, R. J. Mol. Evol. (1988) [Pubmed]
  11. Pitfalls of the synthetic lethality screen in Saccharomyces cerevisiae: an improved design. Koren, A., Ben-Aroya, S., Steinlauf, R., Kupiec, M. Curr. Genet. (2003) [Pubmed]
  12. The N-end rule pathway is required for import of histidine in yeast lacking the kinesin-like protein Cin8p. Xie, Y., Varshavsky, A. Curr. Genet. (1999) [Pubmed]
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