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Gene Review

FLO8  -  Flo8p

Saccharomyces cerevisiae S288c

Synonyms: PDH5, PHD5, Protein PDH5, STA10, Transcriptional activator FLO8, ...
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High impact information on FLO8

  • First, regulation via the MAPK pathway requires the transcription factors Ste12p/Tec1p, whereas cAMP-mediated activation requires a distinct factor, Flo8p [1].
  • In the final step, Flo8 and Mss11 directly promote association of RNA polymerase II with the STA1 promoter to activate STA1 expression [2].
  • PKA signals pseudohyphal growth, in part, by regulating Flo8-dependent expression of the cell surface flocculin Flo11 [3].
  • Deleting FLO8 in C. albicans blocked hyphal development and hypha-specific gene expression [4].
  • The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans [4].

Biological context of FLO8


Associations of FLO8 with chemical compounds


Regulatory relationships of FLO8


Other interactions of FLO8

  • It is thought that the FLO8 gene encodes a transcriptional activator of the dominant flocculation gene FLO1 in Saccharomyces cerevisiae [10].
  • Moreover, the STA10 repression is suppressed completely or partially by the introduction of a single copy of the FLO8 or MSS11 genes [5].
  • Signaling pathway-responsive transcription factors such as Ste12, Tec1, and Flo8 are known to mediate filamentation-specific transcription [11].
  • Although inactivation of Hsl1 is sufficient to suppress the defect in filamentous growth caused by inactivation of Tec1 or Flo8, it is insufficient to promote filamentous growth in the absence of both factors [12].
  • We conclude that the Swe1 kinase modulates filamentous development under a broad spectrum of conditions and that its role is partially redundant with the Tec1 and Flo8 transcription factors [12].


  1. MAP kinase and cAMP filamentation signaling pathways converge on the unusually large promoter of the yeast FLO11 gene. Rupp, S., Summers, E., Lo, H.J., Madhani, H., Fink, G. EMBO J. (1999) [Pubmed]
  2. Recruitment of the Swi/Snf complex by Ste12-Tec1 promotes Flo8-Mss11-mediated activation of STA1 expression. Kim, T.S., Kim, H.Y., Yoon, J.H., Kang, H.S. Mol. Cell. Biol. (2004) [Pubmed]
  3. Cyclic AMP-dependent protein kinase regulates pseudohyphal differentiation in Saccharomyces cerevisiae. Pan, X., Heitman, J. Mol. Cell. Biol. (1999) [Pubmed]
  4. The Flo8 transcription factor is essential for hyphal development and virulence in Candida albicans. Cao, F., Lane, S., Raniga, P.P., Lu, Y., Zhou, Z., Ramon, K., Chen, J., Liu, H. Mol. Biol. Cell (2006) [Pubmed]
  5. STA10 repression of STA gene expression is caused by a defective activator, flo8, in Saccharomyces cerevisiae. Kim, T.S., Ahn, J.Y., Yoon, J.H., Kang, H.S. Curr. Genet. (2003) [Pubmed]
  6. Review: the dominant flocculation genes of Saccharomyces cerevisiae constitute a new subtelomeric gene family. Teunissen, A.W., Steensma, H.Y. Yeast (1995) [Pubmed]
  7. Saccharomyces cerevisiae S288C has a mutation in FLO8, a gene required for filamentous growth. Liu, H., Styles, C.A., Fink, G.R. Genetics (1996) [Pubmed]
  8. Functional characterization of the Saccharomyces cerevisiae VHS3 gene: a regulatory subunit of the Ppz1 protein phosphatase with novel, phosphatase-unrelated functions. Ruiz, A., Muñoz, I., Serrano, R., González, A., Simón, E., Ariño, J. J. Biol. Chem. (2004) [Pubmed]
  9. The mechanism by which overexpression of Gts1p induces flocculation in a FLO8-inactive strain of the yeast Saccharomyces cerevisiae. Shen, H., Iha, H., Yaguchi, S., Tsurugi, K. FEMS Yeast Res. (2006) [Pubmed]
  10. Analysis of the genes activated by the FLO8 gene in Saccharomyces cerevisiae. Kobayashi, O., Yoshimoto, H., Sone, H. Curr. Genet. (1999) [Pubmed]
  11. Identification of Translational Regulation Target Genes during Filamentous Growth in Saccharomyces cerevisiae: Regulatory Role of Caf20 and Dhh1. Park, Y.U., Hur, H., Ka, M., Kim, J. Eukaryotic Cell (2006) [Pubmed]
  12. A role for the Swe1 checkpoint kinase during filamentous growth of Saccharomyces cerevisiae. La Valle, R., Wittenberg, C. Genetics (2001) [Pubmed]
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