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Gene Review

TYR1  -  pprephenate dehydrogenase (NADP(+))

Saccharomyces cerevisiae S288c

Synonyms: PRDH, YBR1218, YBR166C
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High impact information on TYR1

  • In addition, one of the recombinant plasmids was capable of complementing a mutation in tyr1, a gene genetically linked to cdc28 [1].
  • Presumably, the expression of TYR1 is not under the general GCN4 control [2].
  • Characterization of the prephenate dehydrogenase-encoding gene, TYR1, from Saccharomyces cerevisiae [2].
  • These data were obtained by analysing CAT activity in constructs containing promoter fragments of TYR1 and the cat reporter gene [2].
  • The nucleotide sequence of a 3.1-kb region carrying the TYR1 gene and adjacent regions has been determined [2].

Biological context of TYR1

  • The transformants that were obtained carried plasmids harbouring the TYR1 gene, which codes for one of the enzymes involved in tyrosine biosynthesis [3].
  • The mutation is semi-dominant and is located on the right arm of chromosome II in the order: tsm134--lys2--pgi1--tyr1 approximately 15 map units from tyr1 [4].
  • The DNA fragment containing the gene is part of a 45-kb cosmid clone which represents a region of chromosome II covering the genetically mapped tyr1 locus [2].
  • A DNA replication mutant of yeast, cdc8, was found to decrease UV-induced reversion of lys2-1, arg4-17, tyr1 and ura1 [5].
  • The fdp mutation has been localized on the genome of Saccharomyces carlsbergensis, on chromosome II, between lys2 and tyr1, at a man distance of 31 centimorgan from lys2 [6].

Associations of TYR1 with chemical compounds


Other interactions of TYR1


  1. Isolation of genes by complementation in yeast: molecular cloning of a cell-cycle gene. Nasmyth, K.A., Reed, S.I. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  2. Characterization of the prephenate dehydrogenase-encoding gene, TYR1, from Saccharomyces cerevisiae. Mannhaupt, G., Stucka, R., Pilz, U., Schwarzlose, C., Feldmann, H. Gene (1989) [Pubmed]
  3. Tyrosine is involved in protection from oxidative stress in Saccharomyces cerevisiae. Lupo, S., Aranda, C., Miranda-Ham, L., Olivera, H., Riego, L., Servin, L., González, A. Can. J. Microbiol. (1997) [Pubmed]
  4. Genetic studies with a phosphoglucose isomerase mutant of Saccharomyces cerevisiae. Maitra, P.K., Lobo, Z. Mol. Gen. Genet. (1977) [Pubmed]
  5. Decreased UV mutagenesis in cdc8, a DNA replication mutant of Saccharomyces cerevisiae. Prakash, L., Hinkle, D., Prakash, S. Mol. Gen. Genet. (1979) [Pubmed]
  6. Characterization of a regulatory mutant of fructose 1,6-bisphosphatase in Saccharomyces carlsbergensis. van de Poll, K.W., Schamhart, D.H. Mol. Gen. Genet. (1977) [Pubmed]
  7. Saccharomyces cerevisiae strains sensitive to inorganic mercury. I. Effect of tyrosine. Ono, B., Sakamoto, E. Curr. Genet. (1985) [Pubmed]
  8. Chimeric plasmids for cloning of deoxyribonucleic acid sequences in Saccharomyces cerevisiae. Storms, R.K., McNeil, J.B., Khandekar, P.S., An, G., Parker, J., Friesen, J.D. J. Bacteriol. (1979) [Pubmed]
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