Gene Review:
LYS2 - L-aminoadipate-semialdehyde dehydrogenase
Saccharomyces cerevisiae S288c
Synonyms:
Alpha-AR, Alpha-aminoadipate reductase, YBR0910, YBR115C
- Posttranslational activation, site-directed mutation and phylogenetic analyses of the lysine biosynthesis enzymes alpha-aminoadipate reductase Lys1p (AAR) and the phosphopantetheinyl transferase Lys7p (PPTase) from Schizosaccharomyces pombe. Guo, S., Bhattacharjee, J.K. Yeast (2004)
- Epigenetic effects on yeast transcription caused by mutations in an actin-related protein present in the nucleus. Jiang, Y.W., Stillman, D.J. Genes Dev. (1996)
- Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein. Marcand, S., Buck, S.W., Moretti, P., Gilson, E., Shore, D. Genes Dev. (1996)
- Role of conserved sequence elements in yeast centromere DNA. Panzeri, L., Landonio, L., Stotz, A., Philippsen, P. EMBO J. (1985)
- Identification of two genes coding for the translation elongation factor EF-1 alpha of S. cerevisiae. Schirmaier, F., Philippsen, P. EMBO J. (1984)
- The Saccharomyces cerevisiae MLH3 gene functions in MSH3-dependent suppression of frameshift mutations. Flores-Rozas, H., Kolodner, R.D. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae. Jiang, Y.W., Stillman, D.J. Mol. Cell. Biol. (1992)
- Molecular cloning of CIF1, a yeast gene necessary for growth on glucose. González, M.I., Stucka, R., Blázquez, M.A., Feldmann, H., Gancedo, C. Yeast (1992)
- Molecular analysis of yeast chromosome II between CMD1 and LYS2: the excision repair gene RAD16 located in this region belongs to a novel group of double-finger proteins. Mannhaupt, G., Stucka, R., Ehnle, S., Vetter, I., Feldmann, H. Yeast (1992)
- Cloning and biochemical characterization of LYS5 gene of Saccharomyces cerevisiae. Borell, C.W., Bhattacharjee, J.K. Curr. Genet. (1988)
- Role of modified nucleosides in tRNA: effect of modification of the 2-thiouridine derivative located at the 5'-end of the anticodon of yeast transfer RNA Lys2. Sen, G.C., Ghosh, H.P. Nucleic Acids Res. (1976)
- Cloning and sequence of the LYS2 homologue gene from the osmotolerant yeast Pichia sorbitophila. Bleykasten-Grosshans, C., Prior, C., Potier, S. Yeast (2001)
- Molecular analysis of the LYS2 gene of Candida albicans: homology to peptide antibiotic synthetases and the regulation of the alpha-aminoadipate reductase. Suvarna, K., Seah, L., Bhattacherjee, V., Bhattacharjee, J.K. Curr. Genet. (1998)
- Biosynthetic and regulatory role of lys9 mutants of Saccharomyces cerevisiae. Winston, M.K., Bhattacharjee, J.K. Curr. Genet. (1987)
- Novel posttranslational activation of the LYS2-encoded alpha-aminoadipate reductase for biosynthesis of lysine and site-directed mutational analysis of conserved amino acid residues in the activation domain of Candida albicans. Guo, S., Evans, S.A., Wilkes, M.B., Bhattacharjee, J.K. J. Bacteriol. (2001)
- REV7, a new gene concerned with UV mutagenesis in yeast. Lawrence, C.W., Das, G., Christensen, R.B. Mol. Gen. Genet. (1985)
- The SPT6 gene is essential for growth and is required for delta-mediated transcription in Saccharomyces cerevisiae. Clark-Adams, C.D., Winston, F. Mol. Cell. Biol. (1987)
- SPT5, an essential gene important for normal transcription in Saccharomyces cerevisiae, encodes an acidic nuclear protein with a carboxy-terminal repeat. Swanson, M.S., Malone, E.A., Winston, F. Mol. Cell. Biol. (1991)
- Properties of revertants of lys2 and lys5 mutants as well as alpha-aminoadipate-semialdehyde dehydrogenase from Saccharomyces cerevisiae. Storts, D.R., Bhattacharjee, J.K. Biochem. Biophys. Res. Commun. (1989)
- Cloning and expression in Escherichia coli of a yeast mannosyltransferase from the asparagine-linked glycosylation pathway. Couto, J.R., Huffaker, T.C., Robbins, P.W. J. Biol. Chem. (1984)
- Site-directed mutational analysis of the novel catalytic domains of alpha-aminoadipate reductase (Lys2p) from Candida albicans. Guo, S., Bhattacharjee, J.K. Mol. Genet. Genomics (2003)
- Identification of the cloned S. cerevisiae LYS2 gene by an integrative transformation approach. Eibel, H., Philippsen, P. Mol. Gen. Genet. (1983)
- Nitrate regulation of alpha-aminoadipate reductase formation and lysine inhibition of its activity in Penicillium chrysogenum and Acremonium chrysogenum. Hijarrubia, M.J., Aparicio, J.F., Martín, J.F. Appl. Microbiol. Biotechnol. (2002)