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Gene Review

URA1  -  dihydroorotate dehydrogenase

Saccharomyces cerevisiae S288c

Synonyms: DHOD, DHODase, DHOdehase, Dihydroorotate dehydrogenase (fumarate), Dihydroorotate oxidase, ...
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Disease relevance of URA1


High impact information on URA1


Biological context of URA1


Anatomical context of URA1


Associations of URA1 with chemical compounds


Other interactions of URA1

  • Its organization and regulation indicate that the S. pombe URA1 gene product appears very similar to the S. cerevisiae URA2 gene product [14].
  • No evidence of intracistronic complementation was found, and enzymatic analysis of leaky mutants did not reveal any mutations dissociating regulation of URA1 from that of URA3 [7].
  • The APN1 locus is located approximately 235 kb from the left telomere of chromosome XI, and shows weak (approximately 53 cM) genetic linkage to ura1 [15].
  • Identification of the known loci URA1, TRP3 and SAC1 revealed a translocation compared to the genetic map [12].

Analytical, diagnostic and therapeutic context of URA1


  1. Nucleotide sequence of the URA1 gene of Saccharomyces cerevisiae. Roy, A. Gene (1992) [Pubmed]
  2. Expression of a cloned Saccharomyces cerevisiae gene (URA1) is controlled by a bacterial promoter in E. coli and by a yeast promoter in S. cerevisiae. Loison, G., Jund, R. Gene (1981) [Pubmed]
  3. Sequence analysis of the URA1 gene encoding orotidine-5'-monophosphate decarboxylase of Schizophyllum commune. Froeliger, E.H., Ullrich, R.C., Novotny, C.P. Gene (1989) [Pubmed]
  4. Two different dihydroorotate dehydrogenases in Lactococcus lactis. Andersen, P.S., Jansen, P.J., Hammer, K. J. Bacteriol. (1994) [Pubmed]
  5. Divergent evolution of pyrimidine biosynthesis between anaerobic and aerobic yeasts. Nagy, M., Lacroute, F., Thomas, D. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  6. cis- and trans-acting regulatory elements of the yeast URA3 promoter. Roy, A., Exinger, F., Losson, R. Mol. Cell. Biol. (1990) [Pubmed]
  7. Yeast regulatory gene PPR1. II. Chromosomal localization, meiotic map, suppressibility, dominance/recessivity and dosage effect. Liljelund, P., Losson, R., Kammerer, B., Lacroute, F. J. Mol. Biol. (1984) [Pubmed]
  8. Yeast promoters URA1 and URA3. Examples of positive control. Losson, R., Fuchs, R.P., Lacroute, F. J. Mol. Biol. (1985) [Pubmed]
  9. The mapping of chromosomes in Saccharomyces cerevisiae. I. A cosmid vector designed to establish, by cloning into cdc-mutants, numerous start loci for chromosome walking in the yeast genome. Breter, H.J., Knoop, M.T., Kirchen, H. Gene (1987) [Pubmed]
  10. Enzymatic activities of Ura2 and Ura1 proteins (aspartate carbamoyltransferase and dihydro-orotate dehydrogenase) are present in both isolated membranes and cytoplasm of Saccharomyces cerevisiae. Vorísek, J., Techniková, Z., Schwippel, J., Benoist, P. Yeast (2002) [Pubmed]
  11. Ultracytochemical localization of dihydroorotate dehydrogenase in mitochondria and vacuoles of Saccharomyces cerevisiae. Vorísek, J., Pazlarová, J., Hervé, G. Folia Microbiol. (Praha) (1993) [Pubmed]
  12. The complete sequencing of a 24.6 kb segment of yeast chromosome XI identified the known loci URA1, SAC1 and TRP3, and revealed 6 new open reading frames including homologues to the threonine dehydratases, membrane transporters, hydantoinases and the phospholipase A2-activating protein. Tzermia, M., Horaitis, O., Alexandraki, D. Yeast (1994) [Pubmed]
  13. Contribution of horizontal gene transfer to the evolution of Saccharomyces cerevisiae. Hall, C., Brachat, S., Dietrich, F.S. Eukaryotic Cell (2005) [Pubmed]
  14. As in Saccharomyces cerevisiae, aspartate transcarbamoylase is assembled on a multifunctional protein including a dihydroorotase-like cryptic domain in Schizosaccharomyces pombe. Lollier, M., Jaquet, L., Nedeva, T., Lacroute, F., Potier, S., Souciet, J.L. Curr. Genet. (1995) [Pubmed]
  15. The use of random-breakage mapping to locate the genes APN1 and YUH1 in the Saccharomyces genome, and to determine gene order near the left end of chromosome XI. Game, J., Bell, M., Ramotar, D., Miller, H. Yeast (1994) [Pubmed]
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