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Gene Review

CSE1  -  Cse1p

Saccharomyces cerevisiae S288c

Synonyms: Chromosome segregation protein CSE1, HRC135, Importin alpha re-exporter, YGL238W
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High impact information on CSE1

  • Interestingly, various proteins involved in nuclear-cytoplasmic traffic, such as exportins Cse1p, Mex67p, and Los1p, exhibit a robust BA [1].
  • Cse1 mediates nuclear export of importin alpha, the nuclear localization signal (NLS) import adaptor [2].
  • Human CAS cDNA contains a 971-aa open reading frame that is homologous to the essential yeast gene CSE1 [3].
  • Srp1p, the Saccharomyces cerevisiae homologue of importin alpha, returns from the nucleus in a complex with its export factor Cse1p and with Gsp1p (yeast Ran) in its GTP-bound state [4].
  • Purified Cse1p binds with high affinity to Srp1p only in the presence of RanGTP [5].

Biological context of CSE1


Anatomical context of CSE1


Associations of CSE1 with chemical compounds

  • Among them, one gene, designated as SCS2, also suppressed the choline-sensitive dominant mutation, CSE1 [Hosaka, K. et al. (1992) J. Biochem. 111, 352-358] [9].
  • In CSE1, the level of inositol-1-phosphate synthase was low and was greatly repressed on the addition of choline alone [10].
  • A dominant, single nuclear gene mutation, CSE1, caused inositol auxotrophy in yeast cells [10].

Physical interactions of CSE1

  • After carrying its cargo into the nucleus, the importin dimer dissociates, and Srp1p (the yeast importin alpha subunit) is recycled to the cytoplasm in a complex with Cse1p and RanGTP [11].

Other interactions of CSE1


  1. Chromatin boundaries in budding yeast: the nuclear pore connection. Ishii, K., Arib, G., Lin, C., Van Houwe, G., Laemmli, U.K. Cell (2002) [Pubmed]
  2. The structure of the nuclear export receptor Cse1 in its cytosolic state reveals a closed conformation incompatible with cargo binding. Cook, A., Fernandez, E., Lindner, D., Ebert, J., Schlenstedt, G., Conti, E. Mol. Cell (2005) [Pubmed]
  3. The human CAS protein which is homologous to the CSE1 yeast chromosome segregation gene product is associated with microtubules and mitotic spindle. Scherf, U., Pastan, I., Willingham, M.C., Brinkmann, U. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  4. Nup2p, a yeast nucleoporin, functions in bidirectional transport of importin alpha. Solsbacher, J., Maurer, P., Vogel, F., Schlenstedt, G. Mol. Cell. Biol. (2000) [Pubmed]
  5. Cse1p is involved in export of yeast importin alpha from the nucleus. Solsbacher, J., Maurer, P., Bischoff, F.R., Schlenstedt, G. Mol. Cell. Biol. (1998) [Pubmed]
  6. Nup2p is located on the nuclear side of the nuclear pore complex and coordinates Srp1p/importin-alpha export. Hood, J.K., Casolari, J.M., Silver, P.A. J. Cell. Sci. (2000) [Pubmed]
  7. CSE1 and CSE2, two new genes required for accurate mitotic chromosome segregation in Saccharomyces cerevisiae. Xiao, Z., McGrew, J.T., Schroeder, A.J., Fitzgerald-Hayes, M. Mol. Cell. Biol. (1993) [Pubmed]
  8. Antisense inhibition of CAS, the human homologue of the yeast chromosome segregation gene CSE1, interferes with mitosis in HeLa cells. Ogryzko, V.V., Brinkmann, E., Howard, B.H., Pastan, I., Brinkmann, U. Biochemistry (1997) [Pubmed]
  9. Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae. Nikawa, J., Murakami, A., Esumi, E., Hosaka, K. J. Biochem. (1995) [Pubmed]
  10. A dominant mutation that alters the regulation of INO1 expression in Saccharomyces cerevisiae. Hosaka, K., Nikawa, J., Kodaki, T., Yamashita, S. J. Biochem. (1992) [Pubmed]
  11. The yeast nucleoporin Nup2p is involved in nuclear export of importin alpha/Srp1p. Booth, J.W., Belanger, K.D., Sannella, M.I., Davis, L.I. J. Biol. Chem. (1999) [Pubmed]
  12. Cloning and characterization of the SCS1 gene required for the expression of genes in yeast phospholipid synthesis. Hosaka, K., Nikawa, J., Kodaki, T., Yamashita, S. J. Biochem. (1994) [Pubmed]
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