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Gene Review

CSE1L  -  CSE1 chromosome segregation 1-like (yeast)

Homo sapiens

Synonyms: CAS, CSE1, Cellular apoptosis susceptibility protein, Chromosome segregation 1-like protein, Exp2, ...
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Disease relevance of CSE1L

  • High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression [1].
  • CAS is located on chromosome 20q13, a locus often amplified in cancers of various origin, e.g. colonic or breast cancer [2].
  • In univariate analysis, residual tumor, FIGO stage and grade, ZNF217 amplification, and CAS levels predicted outcome (all P < .05) [3].
  • In ductal and lobular in situ carcinomas (n=17), 70-90% of the tumor cells were positive for anti-CAS staining which was predominantly cytoplasmatic [4].
  • In invasive ductal and lobular carcinomas (n =20), 70-90% of the tumor cells stained positive with anti-CAS in a predominantly nuclear pattern [4].

Psychiatry related information on CSE1L

  • Weekly evaluation included a diary in which the number, severity, and duration of full-blown and limited panic attacks and the duration and severity of anticipating fear, CAS, GAS, CGI, HAM-D, adverse effects and the number of capsules not taken were noted [5].
  • Twenty patients with PD with or without agoraphobia (DSM-III-R criteria) were treated openly with citalopram and assessed with CAS, MADRS, SCL-90 the Agoraphobia Scale, other self-ratings, and a panic diary [6].
  • Psychometric data have been generated for the CAS and the K-SADS, with considerably more studies conducted with the CAS [7].
  • Evidence-based decision-making (EBDM) and knowledge translation (KT) are expanded upon in the context of CAS and participatory environments [8].
  • The Choice Assessment Scale (CAS: Research in Developmental Disabilities 20 (1999) 379-384) is a 60-item instrument to identify potential reinforcers for people with severe and profound mental retardation [9].

High impact information on CSE1L


Chemical compound and disease context of CSE1L


Biological context of CSE1L


Anatomical context of CSE1L


Associations of CSE1L with chemical compounds


Physical interactions of CSE1L

  • Human CAS/CSE1L can bind select genes with significant functional consequences for p53-mediated transcription and determine cellular outcome [27].

Other interactions of CSE1L

  • There was a significant positive correlation between CAS and PCNA LI (p<0.05) [20].
  • Six of 7 cases with high expression (p53 Labeling Index > 30 per cent using a CAS 200 image analyser) had p53 mutation [28].
  • For DIA, Feulgen-stained cells were quantified with a CAS 200 image analyzer (Bacus Laboratories, Lombard, IL), and for FISH, the UroVysion probe set (Vysis, Downers Grove, IL) consisting of chromosome enumeration probes 3, 7, 17, and locus-specific identifier probe 9p21 (p16 gene) was used [29].
  • Two other beta karyopherin family members, CRM1 and CAS, mediate export of proteins containing leucine-rich nuclear export signals (NES) and reexport of karyopherin alpha, respectively [30].
  • The results were quantitatively evaluated using a CAS 200 Image Analyzer (Cell Analysis System, Elmhurst, Ill., USA) and were compared with histological findings and clinical course [31].

Analytical, diagnostic and therapeutic context of CSE1L


  1. High expression of the proliferation and apoptosis associated CSE1L/CAS gene in hepatitis and liver neoplasms: correlation with tumor progression. Wellmann, A., Flemming, P., Behrens, P., Wuppermann, K., Lang, H., Oldhafer, K., Pastan, I., Brinkmann, U. Int. J. Mol. Med. (2001) [Pubmed]
  2. CSE1L/CAS: its role in proliferation and apoptosis. Behrens, P., Brinkmann, U., Wellmann, A. Apoptosis (2003) [Pubmed]
  3. CAS (cellular apoptosis susceptibility) gene expression in ovarian carcinoma: Correlation with 20q13.2 copy number and cyclin D1, p53, and Rb protein expression. Peiró, G., Diebold, J., Löhrs, U. Am. J. Clin. Pathol. (2002) [Pubmed]
  4. Implication of the proliferation and apoptosis associated CSE1L/CAS gene for breast cancer development. Behrens, P., Brinkmann, U., Fogt, F., Wernert, N., Wellmann, A. Anticancer Res. (2001) [Pubmed]
  5. Fluvoxamine or placebo in the treatment of panic disorder and relationship to blood concentrations of fluvoxamine. Sandmann, J., Lörch, B., Bandelow, B., Härtter, S., Winter, P., Hiemke, C., Benkert, O. Pharmacopsychiatry (1998) [Pubmed]
  6. Serotonin, panic disorder and agoraphobia: short-term and long-term efficacy of citalopram in panic disorders. Humble, M., Wistedt, B. International clinical psychopharmacology. (1992) [Pubmed]
  7. Structured interviews for assessing children. Hodges, K. Journal of child psychology and psychiatry, and allied disciplines. (1993) [Pubmed]
  8. Evidence-based decision-making in healthcare: exploring the issues though the lens of complex, adaptive systems theory. Lindstrom, R.R. HealthcarePapers. (2003) [Pubmed]
  9. The internal consistency and factor structure of the Choice Assessment Scale. Sturmey, P., Matson, J.L., Lott, J.D. Research in developmental disabilities. (2003) [Pubmed]
  10. Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy. Ali, M., Ponchel, F., Wilson, K.E., Francis, M.J., Wu, X., Verhoef, A., Boylston, A.W., Veale, D.J., Emery, P., Markham, A.F., Lamb, J.R., Isaacs, J.D. J. Clin. Invest. (2001) [Pubmed]
  11. Qualitative and quantitative changes in sialomucins during 1,2-dimethylhydrazine-induced colon carcinogenesis in the rat. McGarrity, T.J., Via, E.A., Colony, P.C. J. Natl. Cancer Inst. (1987) [Pubmed]
  12. Enhancement of benzo[a]pyrene-induced sister chromatid exchanges in lymphocytes from cigarette smokers occupationally exposed to asbestos. Kelsey, K.T., Christiani, D.C., Little, J.B. J. Natl. Cancer Inst. (1986) [Pubmed]
  13. Effects of dietary selenium on bis(2-oxopropyl)nitrosamine-induced carcinogenesis in Syrian golden hamsters. Birt, D.F., Julius, A.D., Runice, C.E., Salmasi, S. J. Natl. Cancer Inst. (1986) [Pubmed]
  14. Histopathology of methylbenzylnitrosamine-induced esophageal carcinoma in the rat: comparison with cytomorphology. Barch, D.H., Walloch, J., Hedvegi, D., Iannaccone, P.M. J. Natl. Cancer Inst. (1986) [Pubmed]
  15. High incidence of hepatocellular carcinomas after synthetic estrogen administration in Syrian golden hamsters fed alpha-naphthoflavone: a new tumor model. Li, J.J., Li, S.A. J. Natl. Cancer Inst. (1984) [Pubmed]
  16. Test of catechol, tannic acid, Bidens pilosa, croton oil, and phorbol for cocarcinogenesis of esophageal tumors induced in rats by methyl-n-amylnitrosamine. Mirvish, S.S., Salmasi, S., Lawson, T.A., Pour, P., Sutherland, D. J. Natl. Cancer Inst. (1985) [Pubmed]
  17. Neurologic abnormalities in workers of a 1-bromopropane factory. Ichihara, G., Li, W., Shibata, E., Ding, X., Wang, H., Liang, Y., Peng, S., Itohara, S., Kamijima, M., Fan, Q., Zhang, Y., Zhong, E., Wu, X., Valentine, W.M., Takeuchi, Y. Environ. Health Perspect. (2004) [Pubmed]
  18. Subchronic toxicity of ethylene glycol in Wistar and F-344 rats related to metabolism and clearance of metabolites. Cruzan, G., Corley, R.A., Hard, G.C., Mertens, J.J., McMartin, K.E., Snellings, W.M., Gingell, R., Deyo, J.A. Toxicol. Sci. (2004) [Pubmed]
  19. CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cells. Jiang, M.C., Liao, C.F., Tai, C.C. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  20. Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma. Shiraki, K., Fujikawa, K., Sugimoto, K., Ito, T., Yamanaka, T., Suzuki, M., Yoneda, K., Sugimoto, K., Takase, K., Nakano, T. Int. J. Mol. Med. (2006) [Pubmed]
  21. Tissue-specific alternative splicing of the CSE1L/CAS (cellular apoptosis susceptibility) gene. Brinkmann, U., Brinkmann, E., Bera, T.K., Wellmann, A., Pastan, I. Genomics (1999) [Pubmed]
  22. Determination of the functional domain organization of the importin alpha nuclear import factor. Herold, A., Truant, R., Wiegand, H., Cullen, B.R. J. Cell Biol. (1998) [Pubmed]
  23. Role of CAS, a human homologue to the yeast chromosome segregation gene CSE1, in toxin and tumor necrosis factor mediated apoptosis. Brinkmann, U., Brinkmann, E., Gallo, M., Scherf, U., Pastan, I. Biochemistry (1996) [Pubmed]
  24. The hCSE1/CAS protein is phosphorylated by HeLa extracts and MEK-1: MEK-1 phosphorylation may modulate the intracellular localization of CAS. Scherf, U., Kalab, P., Dasso, M., Pastan, I., Brinkmann, U. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
  25. Inhibition of NMU-induced mammary tumorigenesis by dietary soy. Simmen, R.C., Eason, R.R., Till, S.R., Chatman, L., Velarde, M.C., Geng, Y., Korourian, S., Badger, T.M. Cancer Lett. (2005) [Pubmed]
  26. Uterine phenotype of young adult rats exposed to dietary soy or genistein during development. Eason, R.R., Till, S.R., Velarde, M.C., Geng, Y., Chatman, L., Gu, L., Badger, T.M., Simmen, F.A., Simmen, R.C. J. Nutr. Biochem. (2005) [Pubmed]
  27. hCAS/CSE1L associates with chromatin and regulates expression of select p53 target genes. Tanaka, T., Ohkubo, S., Tatsuno, I., Prives, C. Cell (2007) [Pubmed]
  28. An evaluation of six antibodies for immunohistochemistry of mutant p53 gene product in archival colorectal neoplasms. Baas, I.O., Mulder, J.W., Offerhaus, G.J., Vogelstein, B., Hamilton, S.R. J. Pathol. (1994) [Pubmed]
  29. Analysis of polyomavirus-infected renal transplant recipients' urine specimens: correlation of routine urine cytology, fluorescence in situ hybridization, and digital image analysis. Kipp, B.R., Sebo, T.J., Griffin, M.D., Ihrke, J.M., Halling, K.C. Am. J. Clin. Pathol. (2005) [Pubmed]
  30. Distinct nuclear import and export pathways mediated by members of the karyopherin beta family. Moroianu, J. J. Cell. Biochem. (1998) [Pubmed]
  31. Clinical significance of mdm2 and p53 expression in bladder cancer. A comparison with cell proliferation and apoptosis. Shiina, H., Igawa, M., Shigeno, K., Yamasaki, Y., Urakami, S., Yoneda, T., Wada, Y., Honda, S., Nagasaki, M. Oncology (1999) [Pubmed]
  32. Cse1l is essential for early embryonic growth and development. Bera, T.K., Bera, J., Brinkmann, U., Tessarollo, L., Pastan, I. Mol. Cell. Biol. (2001) [Pubmed]
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