The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

HXT1  -  Hxt1p

Saccharomyces cerevisiae S288c

Synonyms: HOR4, Low-affinity glucose transporter HXT1, YHR094C
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of HXT1


High impact information on HXT1


Biological context of HXT1

  • This relationship was in broad agreement with the transport kinetics of Hxt1-Hxt7 and Gal2 deduced in previous studies on single-HXT strains [7].
  • The gene HXT1 (hexose transport), isolated from plasmid pSC7, was sequenced and found to encode a hydrophobic protein which is highly homologous to the large family of sugar transporter proteins from eucaryotes and procaryotes [8].
  • Transcription of various known glucose transporter genes (HXT1, HXT3, and HXT4) was defective in HTR1 mutants, leading us to suggest that HTR mutations affect a negative factor of HXT gene expression [9].
  • A glucose response element from the S. cerevisiae hexose transporter HXT1 gene is sensitive to glucose in human fibroblasts [1].
  • In virulence tests, an hxt1 mutant strain showed 12% less phenoloxidase activity than the wild-type strain, and no difference in the ability to form melanin was identified [2].

Anatomical context of HXT1


Associations of HXT1 with chemical compounds

  • The HXT1 protein is 69% identical to GAL2 and 66% identical to HXT2, and all three proteins were found to have a putative leucine zipper motif at a consensus location in membrane-spanning domain 2 [8].

Physical interactions of HXT1

  • Multicopy expression of the HXT1 gene restored high-affinity glucose transport to the snf3 mutant, which is deficient in a significant proportion of high-affinity glucose transport [8].
  • Comprehensive analysis of chimeras of these two proteins has previously revealed that TMs 1, 5, 7, and 8 of Hxt2 are required for high affinity glucose transport activity and that leucine 201 in TM5 is the most important in this regard of the 20 amino acid residues in these regions that differ between Hxt2 and Hxt1 [11].

Regulatory relationships of HXT1


Other interactions of HXT1

  • One suppressor encodes the previously identified glucose transporter HXT1, and another encodes a new member of this family, HXT3 [14].
  • The HXT genes (HXT1 to HXT4) of the yeast Saccharomyces cerevisiae encode hexose transporters [6].
  • Components of the glucose repression pathway (Hxk2p and Reg1p) are also required for generation of the high-level glucose induction signal for expression of the HXT1 gene [6].
  • Transcription of HXT1-HXT7 was correlated with the extracellular glucose concentration in the cultures [7].
  • The consequence of relieving feedback regulation of STD1 expression is that reestablishment of repression of HXT1 expression upon removal of glucose is delayed [15].

Analytical, diagnostic and therapeutic context of HXT1


  1. A glucose response element from the S. cerevisiae hexose transporter HXT1 gene is sensitive to glucose in human fibroblasts. Ferrer-Martínez, A., Riera, A., Jiménez-Chillarón, J.C., Herrero, P., Moreno, F., Gómez-Foix, A.M. J. Mol. Biol. (2004) [Pubmed]
  2. A new hexose transporter from Cryptococcus neoformans: molecular cloning and structural and functional characterization. Chikamori, M., Fukushima, K. Fungal Genet. Biol. (2005) [Pubmed]
  3. The role of haustoria in sugar supply during infection of broad bean by the rust fungus Uromyces fabae. Voegele, R.T., Struck, C., Hahn, M., Mendgen, K. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  4. Efficient export of the glucose transporter Hxt1p from the endoplasmic reticulum requires Gsf2p. Sherwood, P.W., Carlson, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  5. F-box protein Grr1 interacts with phosphorylated targets via the cationic surface of its leucine-rich repeat. Hsiung, Y.G., Chang, H.C., Pellequer, J.L., La Valle, R., Lanker, S., Wittenberg, C. Mol. Cell. Biol. (2001) [Pubmed]
  6. Three different regulatory mechanisms enable yeast hexose transporter (HXT) genes to be induced by different levels of glucose. Ozcan, S., Johnston, M. Mol. Cell. Biol. (1995) [Pubmed]
  7. Glucose uptake kinetics and transcription of HXT genes in chemostat cultures of Saccharomyces cerevisiae. Diderich, J.A., Schepper, M., van Hoek, P., Luttik, M.A., van Dijken, J.P., Pronk, J.T., Klaassen, P., Boelens, H.F., de Mattos, M.J., van Dam, K., Kruckeberg, A.L. J. Biol. Chem. (1999) [Pubmed]
  8. The HXT1 gene product of Saccharomyces cerevisiae is a new member of the family of hexose transporters. Lewis, D.A., Bisson, L.F. Mol. Cell. Biol. (1991) [Pubmed]
  9. Glucose uptake and catabolite repression in dominant HTR1 mutants of Saccharomyces cerevisiae. Ozcan, S., Freidel, K., Leuker, A., Ciriacy, M. J. Bacteriol. (1993) [Pubmed]
  10. Visualization of protein compartmentation within the plasma membrane of living yeast cells. Malínská, K., Malínský, J., Opekarová, M., Tanner, W. Mol. Biol. Cell (2003) [Pubmed]
  11. Eight amino acid residues in transmembrane segments of yeast glucose transporter Hxt2 are required for high affinity transport. Kasahara, T., Ishiguro, M., Kasahara, M. J. Biol. Chem. (2006) [Pubmed]
  12. Active Snf1 protein kinase inhibits expression of the Saccharomyces cerevisiae HXT1 glucose transporter gene. Tomás-Cobos, L., Sanz, P. Biochem. J. (2002) [Pubmed]
  13. Glucose-mediated phosphorylation converts the transcription factor Rgt1 from a repressor to an activator. Mosley, A.L., Lakshmanan, J., Aryal, B.K., Ozcan, S. J. Biol. Chem. (2003) [Pubmed]
  14. Roles of multiple glucose transporters in Saccharomyces cerevisiae. Ko, C.H., Liang, H., Gaber, R.F. Mol. Cell. Biol. (1993) [Pubmed]
  15. Integration of transcriptional and posttranslational regulation in a glucose signal transduction pathway in Saccharomyces cerevisiae. Kim, J.H., Brachet, V., Moriya, H., Johnston, M. Eukaryotic Cell (2006) [Pubmed]
  16. Evidence for involvement of Saccharomyces cerevisiae protein kinase C in glucose induction of HXT genes and derepression of SUC2. Brandão, R.L., Etchebehere, L., Queiroz, C.C., Trópia, M.J., Ernandes, J.R., Gonçalves, T., Loureiro-Dias, M.C., Winderickx, J., Thevelein, J.M., Leiper, F.C., Carling, D., Castro, I.M. FEMS Yeast Res. (2002) [Pubmed]
WikiGenes - Universities