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Gene Review

UFE1  -  Ufe1p

Saccharomyces cerevisiae S288c

Synonyms: Syntaxin UFE1, YOR075W, YOR29-26
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Disease relevance of UFE1

  • We replaced the FHV protein A mitochondrial outer membrane-targeting sequence with the N-terminal endoplasmic reticulum (ER)-targeting sequence from the yeast NADP cytochrome P450 oxidoreductase or inverted C-terminal ER-targeting sequences from the hepatitis C virus NS5B polymerase or the yeast t-SNARE Ufe1p [1].

High impact information on UFE1

  • We propose that the Ufe1 protein acts in the dual capacity of an organelle membrane fusion-associated SNARE by undergoing direct t-t-SNARE and Cdc48p interactions during organelle membrane fusion as well as a t-SNARE for vesicular traffic [2].
  • We present evidence that the fusion of ER membranes requires Ufe1p, a t-SNARE that localizes to the ER, but no known v-SNAREs [2].
  • Organelle membrane fusion: a novel function for the syntaxin homolog Ufe1p in ER membrane fusion [2].
  • Large liposomes containing bound cytoplasmic domains of the v-SNAREs, Sec22p or Bos1p, or of the ER resident proteins, Sec12p and Ufe1p, were exposed to COPII proteins and GMP-PNP. v-SNAREs but not resident proteins were concentrated in synthetic COPII vesicles generated from donor liposomes [3].
  • In yeast, retrograde transport from the Golgi complex to the ER is mediated by the ER t-SNARE Ufe1p, and also requires two other ER proteins, Sec20p and Tip20p, which bind each other [4].

Biological context of UFE1


Anatomical context of UFE1


Other interactions of UFE1

  • Translation of the UFE1 coding region generates a protein with significant similarity to cytokeratin and to the coiled-coil region of SED5, USO1 and restin, suggesting that it is involved in the secretory pathway and may also be related to intermediate filament-associated proteins [5].
  • Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin [7].
  • It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1 [7].
  • Sec20p-interacting proteins (Tip20p, Ufe1p) in the retrograde secretory pathway of the fungal pathogen Candida albicans [8].
  • When the proteoliposomes were mixed with COPII proteins and GMP-PNP, Emp46/47p, but not Ufe1p, were concentrated into COPII vesicles [9].


  1. Engineered retargeting of viral RNA replication complexes to an alternative intracellular membrane. Miller, D.J., Schwartz, M.D., Dye, B.T., Ahlquist, P. J. Virol. (2003) [Pubmed]
  2. Organelle membrane fusion: a novel function for the syntaxin homolog Ufe1p in ER membrane fusion. Patel, S.K., Indig, F.E., Olivieri, N., Levine, N.D., Latterich, M. Cell (1998) [Pubmed]
  3. Coat assembly directs v-SNARE concentration into synthetic COPII vesicles. Matsuoka, K., Morimitsu, Y., Uchida, K., Schekman, R. Mol. Cell (1998) [Pubmed]
  4. A novel SNARE complex implicated in vesicle fusion with the endoplasmic reticulum. Lewis, M.J., Rayner, J.C., Pelham, H.R. EMBO J. (1997) [Pubmed]
  5. Molecular analysis of UFE1, a Saccharomyces cerevisiae gene essential for spore formation and vegetative growth. Downing, T.A., Storms, R.K. Curr. Genet. (1996) [Pubmed]
  6. Transmembrane domain-dependent sorting of proteins to the ER and plasma membrane in yeast. Rayner, J.C., Pelham, H.R. EMBO J. (1997) [Pubmed]
  7. A SNARE required for retrograde transport to the endoplasmic reticulum. Burri, L., Varlamov, O., Doege, C.A., Hofmann, K., Beilharz, T., Rothman, J.E., Söllner, T.H., Lithgow, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Sec20p-interacting proteins (Tip20p, Ufe1p) in the retrograde secretory pathway of the fungal pathogen Candida albicans. Weber, Y., Swoboda, R.K., Ernst, J.F. Mol. Genet. Genomics (2002) [Pubmed]
  9. Reconstitution of coat protein complex II (COPII) vesicle formation from cargo-reconstituted proteoliposomes reveals the potential role of GTP hydrolysis by Sar1p in protein sorting. Sato, K., Nakano, A. J. Biol. Chem. (2004) [Pubmed]
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