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Gene Review

FCN3  -  ficolin (collagen/fibrinogen domain...

Homo sapiens

Synonyms: Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, FCNH, Ficolin-3, HAKA1, ...
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Disease relevance of FCN3


High impact information on FCN3


Chemical compound and disease context of FCN3


Biological context of FCN3


Anatomical context of FCN3


Other interactions of FCN3


Analytical, diagnostic and therapeutic context of FCN3

  • Data from the Ames TA-98 mutagenic bioassay clearly indicate that vai haka is not mutagenic with or without S-9 activation [10].
  • Twenty-six experimental CD-1 white mice were gavaged with 0.1 ml of vai haka (at 540xthe human dose) while the control group of 17 mice were gavaged with 0.1 ml of water to determine teratogenic and developmental effects of the vai haka [10].


  1. Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth. Tsujimura, M., Miyazaki, T., Kojima, E., Sagara, Y., Shiraki, H., Okochi, K., Maeda, Y. Clin. Chim. Acta (2002) [Pubmed]
  2. Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. Sugimoto, R., Yae, Y., Akaiwa, M., Kitajima, S., Shibata, Y., Sato, H., Hirata, J., Okochi, K., Izuhara, K., Hamasaki, N. J. Biol. Chem. (1998) [Pubmed]
  3. Expression of H-ficolin/Hakata antigen, mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 by human glioma cell line T98G. Kuraya, M., Matsushita, M., Endo, Y., Thiel, S., Fujita, T. Int. Immunol. (2003) [Pubmed]
  4. Thermolabile beta-2 macroglycoprotein (Hakata antigen) in liver disease: biochemical and immunohistochemical study. Fukutomi, T., Ando, B., Sakamoto, S., Sakai, H., Nawata, H. Clin. Chim. Acta (1996) [Pubmed]
  5. Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2. Hummelshoj, T., Munthe-Fog, L., Madsen, H.O., Fujita, T., Matsushita, M., Garred, P. Hum. Mol. Genet. (2005) [Pubmed]
  6. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). Matsushita, M., Kuraya, M., Hamasaki, N., Tsujimura, M., Shiraki, H., Fujita, T. J. Immunol. (2002) [Pubmed]
  7. Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. Akaiwa, M., Yae, Y., Sugimoto, R., Suzuki, S.O., Iwaki, T., Izuhara, K., Hamasaki, N. J. Histochem. Cytochem. (1999) [Pubmed]
  8. Detection of serum thermolabile beta-2 macroglycoprotein (Hakata antigen) by enzyme-linked immunosorbent assay using polysaccharide produced by Aerococcus viridans. Tsujimura, M., Ishida, C., Sagara, Y., Miyazaki, T., Murakami, K., Shiraki, H., Okochi, K., Maeda, Y. Clin. Diagn. Lab. Immunol. (2001) [Pubmed]
  9. Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus. Yae, Y., Inaba, S., Sato, H., Okochi, K., Tokunaga, F., Iwanaga, S. Biochim. Biophys. Acta (1991) [Pubmed]
  10. Traditional Tongan cures for morning sickness and their mutagenic/toxicological evaluations. Ostraff, M., Anitoni, K., Nicholson, A., Booth, G.M. Journal of ethnopharmacology. (2000) [Pubmed]
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