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Gene Review

DAP1  -  Dap1p

Saccharomyces cerevisiae S288c

Synonyms: Damage response protein 1, P2515, YPL170W
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Disease relevance of DAP1

  • Cells lacking Dap1p are damage-sensitive, and we have found that inhibition of Hpr6 expression by RNA inhibition (RNAi) increases sensitivity of breast cancer cells to chemotherapeutic drugs [1].

High impact information on DAP1


Biological context of DAP1


Associations of DAP1 with chemical compounds


Regulatory relationships of DAP1

  • Furthermore, Dap1p regulates the stability of Erg11p, and Erg11p is stabilized in dap1Delta cells by the addition of heme [2].
  • Loss of Dap1 is suppressed by elevated levels of Erg11 but not by increased heme biosynthesis [5].

Other interactions of DAP1

  • Genetic analysis indicates that Erg11p acts downstream of Dap1p [2].


  1. Hpr6 (heme-1 domain protein) regulates the susceptibility of cancer cells to chemotherapeutic drugs. Crudden, G., Chitti, R.E., Craven, R.J. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  2. Dap1p, a heme-binding protein that regulates the cytochrome P450 protein Erg11p/Cyp51p in Saccharomyces cerevisiae. Mallory, J.C., Crudden, G., Johnson, B.L., Mo, C., Pierson, C.A., Bard, M., Craven, R.J. Mol. Cell. Biol. (2005) [Pubmed]
  3. Spectroscopic and biochemical characterization of heme binding to yeast Dap1p and mouse PGRMC1p. Ghosh, K., Thompson, A.M., Goldbeck, R.A., Shi, X., Whitman, S., Oh, E., Zhiwu, Z., Vulpe, C., Holman, T.R. Biochemistry (2005) [Pubmed]
  4. Saccharomyces cerevisiae Dap1p, a novel DNA damage response protein related to the mammalian membrane-associated progesterone receptor. Hand, R.A., Jia, N., Bard, M., Craven, R.J. Eukaryotic Cell (2003) [Pubmed]
  5. Regulation of iron homeostasis mediated by the heme-binding protein Dap1 (damage resistance protein 1) via the P450 protein Erg11/Cyp51. Craven, R.J., Mallory, J.C., Hand, R.A. J. Biol. Chem. (2007) [Pubmed]
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