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Pgrmc1  -  progesterone receptor membrane component 1

Rattus norvegicus

Synonyms: 25-DX, 25-Dx, 25Dx, 25dx, Acidic 25 kDa protein, ...
 
 
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Disease relevance of Pgrmc1

  • The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury [1].
  • The intracellular distributions of the cation-independent mannose 6-phosphate receptor (MPR) and a 120-kD lysosomal membrane glycoprotein (lgp120) were studied in rat hepatoma cells [2].
  • These findings suggest a mechanism in which the activation of nuclear P receptor represses expression of a membrane P receptor, 25-Dx, during lordosis facilitation [3].
  • The toxicity in the CNS was measured by the ataxia scale devised by Desmedt, Niemegeers, Lewi and Janssen (Arzneimittel-Forsch, 26: 1592-1602, 1976) [4].
  • Since MPR and lysosomal enzymes were also detected on the ruffled border of osteoclasts (Ocl) adjacent to alveolar bone, our immunocytochemical approach provides strong evidence for a similarity between the maturation process in enamel, as mediated by the ruffle-ended maturation ameloblasts, and bone resorption mediated by osteoclasts [5].
 

High impact information on Pgrmc1

  • We propose that the MPR/lgp-enriched structure is a specialized endosome (prelysosome) that serves as an intermediate compartment into which endocytic vesicles discharge their contents, and where lysosomal enzymes are released from the MPR and packaged along with newly synthesized lysosomal glycoproteins into lysosomes [6].
  • Thus, we hypothesize that during secretory granule maturation, MPR-ligand complexes and syntaxin 6 are removed from IGs by AP-1/clathrin-coated vesicles, and then delivered to endosomes [7].
  • This demonstrates that the delivery of endolyn-78 to this organelle is not mediated by the mannose-6-phosphate receptor (MPR) [8].
  • The combined data suggest that MPR+/lgp120+ vacuoles are endocytic vacuoles, intermediate between MPR+/lgp120-endosomes and MPR-/lgp120+ lysosomes, and represent the site where MPR is sorted from lgp120 destined for lysosomes [2].
  • MPR was present in both endosomal tubules and vacuoles, whereas lgp120 was confined to the endosomal vacuoles [2].
 

Biological context of Pgrmc1

  • The deduced amino acid sequence of VEMA contains a single transmembrane domain near its N-terminus and several tyrosine-based internalization motifs [9].
  • In addition to intracellular progesterone receptors, membrane binding sites of the hormone such as 25-Dx may also be involved in neuroprotection [1].
  • Using quantitative immunogold cytochemistry we found 10% of the cell's MPR located at the cell surface [2].
  • To study the kinetics of appearance of endocytic tracers in MPR-and/or lgp120-containing pools in greater detail, cells were allowed to endocytose horse-radish peroxidase (HRP) for 5-90 min [2].
  • The density of labeling for rat MPR in the extended PLCs was markedly decreased, consistent with membrane fusions and dilution of the antigen upon congregation of the PLC compartments from the donor cells [10].
 

Anatomical context of Pgrmc1

 

Associations of Pgrmc1 with chemical compounds

  • In the present study we investigated the distribution of the membrane-associated progesterone-binding protein 25-Dx in rat brain [1].
  • Double immunofluorescence immunolabelling and confocal microscopy showed that 25-Dx is co-expressed with vasopressin in neurones of the paraventricular, supraoptic and retrochiasmatic nuclei [1].
  • Results indicate that adipose cells possess at least two distinct cell surface recycling pathways for insulin-like growth factor-II/mannose 6-phosphate receptor (MPR) and transferrin receptor (TfR): one which is mediated by glucose transporter isoform 4(Glut4)-vesicles and another that bypasses this compartment [13].
  • Two inhibitors of MPR-mediated enzyme transport, tunicamycin and chloroquine, were used [14].
 

Physical interactions of Pgrmc1

 

Other interactions of Pgrmc1

 

Analytical, diagnostic and therapeutic context of Pgrmc1

References

  1. The membrane-associated progesterone-binding protein 25-Dx is expressed in brain regions involved in water homeostasis and is up-regulated after traumatic brain injury. Meffre, D., Delespierre, B., Gouézou, M., Leclerc, P., Vinson, G.P., Schumacher, M., Stein, D.G., Guennoun, R. J. Neurochem. (2005) [Pubmed]
  2. Sorting of mannose 6-phosphate receptors and lysosomal membrane proteins in endocytic vesicles. Geuze, H.J., Stoorvogel, W., Strous, G.J., Slot, J.W., Bleekemolen, J.E., Mellman, I. J. Cell Biol. (1988) [Pubmed]
  3. A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors. Krebs, C.J., Jarvis, E.D., Chan, J., Lydon, J.P., Ogawa, S., Pfaff, D.W. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  4. The effect of cinromide on "kindled" seizures in the rat. Chiu, P., Lipnowski, S., Bruni, J., Burnham, W.M. Neuropharmacology (1982) [Pubmed]
  5. Immunolocalization of the cation-independent mannose 6-phosphate receptor and cathepsin B in the enamel organ and alveolar bone of the rat incisor. Al Kawas, S., Amizuka, N., Bergeron, J.J., Warshawsky, H. Calcif. Tissue Int. (1996) [Pubmed]
  6. The mannose 6-phosphate receptor and the biogenesis of lysosomes. Griffiths, G., Hoflack, B., Simons, K., Mellman, I., Kornfeld, S. Cell (1988) [Pubmed]
  7. Mannose 6-phosphate receptors are sorted from immature secretory granules via adaptor protein AP-1, clathrin, and syntaxin 6-positive vesicles. Klumperman, J., Kuliawat, R., Griffith, J.M., Geuze, H.J., Arvan, P. J. Cell Biol. (1998) [Pubmed]
  8. Endolyn-78, a membrane glycoprotein present in morphologically diverse components of the endosomal and lysosomal compartments: implications for lysosome biogenesis. Croze, E., Ivanov, I.E., Kreibich, G., Adesnik, M., Sabatini, D.D., Rosenfeld, M.G. J. Cell Biol. (1989) [Pubmed]
  9. Cloning and expression of VEMA: a novel ventral midline antigen in the rat CNS. Runko, E., Wideman, C., Kaprielian, Z. Mol. Cell. Neurosci. (1999) [Pubmed]
  10. Comparative behavior of lysosomes and the pre-lysosome compartment (PLC) in in vivo cell fusion experiments. Deng, Y.P., Griffiths, G., Storrie, B. J. Cell. Sci. (1991) [Pubmed]
  11. Expression and localization of 25-Dx, a membrane-associated putative progesterone-binding protein, in the developing Purkinje cell. Sakamoto, H., Ukena, K., Takemori, H., Okamoto, M., Kawata, M., Tsutsui, K. Neuroscience (2004) [Pubmed]
  12. Ultrastructural localization of the mannose 6-phosphate receptor in rat liver. Geuze, H.J., Slot, J.W., Strous, G.J., Hasilik, A., Von Figura, K. J. Cell Biol. (1984) [Pubmed]
  13. Insulin regulation of protein traffic in rat adipose cells. Kandror, K.V. J. Biol. Chem. (1999) [Pubmed]
  14. Autophagic vacuoles fuse with the prelysosomal compartment in cultured rat fibroblasts. Punnonen, E.L., Autio, S., Kaija, H., Reunanen, H. Eur. J. Cell Biol. (1993) [Pubmed]
  15. Effects of injury and progesterone treatment on progesterone receptor and progesterone binding protein 25-Dx expression in the rat spinal cord. Labombarda, F., Gonzalez, S.L., Deniselle, M.C., Vinson, G.P., Schumacher, M., De Nicola, A.F., Guennoun, R. J. Neurochem. (2003) [Pubmed]
  16. Progesterone membrane receptor component 1 expression in the immature rat ovary and its role in mediating progesterone's antiapoptotic action. Peluso, J.J., Pappalardo, A., Losel, R., Wehling, M. Endocrinology (2006) [Pubmed]
 
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